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The map label for this gene is thrC [H]

Identifier: 220903391

GI number: 220903391

Start: 137283

End: 138728

Strand: Direct

Name: thrC [H]

Synonym: Ddes_0105

Alternate gene names: 220903391

Gene position: 137283-138728 (Clockwise)

Preceding gene: 220903390

Following gene: 220903392

Centisome position: 4.78

GC content: 61.27

Gene sequence:

>1446_bases
ATGGCCCACGCGGATTTTCCGGCCTATCGCGGCCGCATGGAATATGTCTGCCTTGATTGCGGCGCGCGCTACCCGGGCGA
CAGCCTGCTGTATACCTGCCCGCAGTGCGGCGGCGTTTTTCTGCTGGAAAACCTGGATTTTGCCAGGCTCAAAGAACGCA
GCGGCCAGGAATGGCGAAAGATTTTTGACGATCGCTGCGCCAGCCGCTCCACAGCGCTCAAGGGGATTTTCCGGTATTAC
GAGCTGCTCGCCCCCCTGCTGGACGAAGACGATATCGTCTATCTGGGCGAAGGCATTACTCCGGTGGTGGAAGCTTCCGC
TGCCCTGCGTGACATGACGGGCGTGGCTTTTGCCTACAAAAATGACGGGCAGAACCCCAGCGCCTCCTTCAAGGACAGGG
GCATGGCCTGTGCCTTCAGCTATCTCAAGTGGCTTTGCCGTCGCAACCAGTGGGACGAAGTGCTGACGGTCTGCGCCTCC
ACCGGCGACACTTCGGCAGCCGCGGCCCTGTACGCCTCCTATGTAGGCGCGCCGCTCAAATCCGTGGTACTGCTGCCCCA
CGGCAAGGTGACGCCCCAGCAGCTTGCGCAGCCCCTTGGCAGCGGCGCCACAGTGCTGGAATTGCCCGGCGTGTTTGACG
ACTGCATGAAGGTGGTGGAGCTGCTGGCAGAAAACTACCGCGTGGCGCTGCTCAACTCCAAGAACAGCTGGCGCATTCTG
GGGCAGGAGTCCTACGCGTATGAAGTGGCCCAGTGGTATGGCTGGGATATGACGGACCAGTGTCTCTTTGTGCCCATTGG
CAATGCGGGCAACGTCACCGCCATCATGTCGGGCTTTTTGAAAATGCTTGATCTTGGCATGATTACGGGCCTGCCGCGCA
TCTTCGGCGTGCAGTCCGAGCATGCCGATCCGGTGTGGCGCTACTATGACGCCCCCGCAGGCTCCCGCTGCTGGCAGCCG
GTGACCGTACAGCCCAGCGTGGCCCAGGCGGCCATGATAGGCAATCCCGTTTCATTTCCGCGCGTGCGCATGCTGGCCGA
GCGGTTTATGGAAAGCGGCGGCGAGCGCGCCTTCCAGGTGGTGCGCGTAACCGAGCAGCAGATTATGGATGCGATGATTA
TGGCAAACCGTCACGGTCACATTGCCTGTACCCAGGGCGGCGAATGTTTGGCCGGTTTGCGCAATGCCCGCACTCTGGGC
CTTGTGGGCGACCACGAGCACGCTGTGCTTGACGCCACGGCCCATGCCCTCAAGTTTGCCGGGTTTCAGGACATGTATTT
CAACGATGCCTTCCCGCCCGAGTATGGCGTATCGCCGGACAAGAGCCTGGCAAACCTGCCGGAACTGCTTCTGCCCCAGA
GCGCCCGCGAAGGGCGGGATGTGGCGGAATTCGCCTCACTGGGGGCGGAAGCAGTGGTGCAGCGTTTGAAATTGCAGAAA
AAATAA

Upstream 100 bases:

>100_bases
TAAAATGTTCCGGAGCGTTCCCGGAGGAATGCTCCGGCGGCGGCACGAGCCACCGCTGGATAAACGGTTTCTGTTCCTGA
TGCCAAAAGGAGTTCGTCAC

Downstream 100 bases:

>100_bases
GGTTTTTTGTCATAGGCTGTATTAAAGAAAGGGACTTTATTTGCAAAGGTCCCTTTTTTGCTTTAGCTGTGAAGAATTGA
AAAACATAGCAGAAAAATAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MAHADFPAYRGRMEYVCLDCGARYPGDSLLYTCPQCGGVFLLENLDFARLKERSGQEWRKIFDDRCASRSTALKGIFRYY
ELLAPLLDEDDIVYLGEGITPVVEASAALRDMTGVAFAYKNDGQNPSASFKDRGMACAFSYLKWLCRRNQWDEVLTVCAS
TGDTSAAAALYASYVGAPLKSVVLLPHGKVTPQQLAQPLGSGATVLELPGVFDDCMKVVELLAENYRVALLNSKNSWRIL
GQESYAYEVAQWYGWDMTDQCLFVPIGNAGNVTAIMSGFLKMLDLGMITGLPRIFGVQSEHADPVWRYYDAPAGSRCWQP
VTVQPSVAQAAMIGNPVSFPRVRMLAERFMESGGERAFQVVRVTEQQIMDAMIMANRHGHIACTQGGECLAGLRNARTLG
LVGDHEHAVLDATAHALKFAGFQDMYFNDAFPPEYGVSPDKSLANLPELLLPQSAREGRDVAEFASLGAEAVVQRLKLQK
K

Sequences:

>Translated_481_residues
MAHADFPAYRGRMEYVCLDCGARYPGDSLLYTCPQCGGVFLLENLDFARLKERSGQEWRKIFDDRCASRSTALKGIFRYY
ELLAPLLDEDDIVYLGEGITPVVEASAALRDMTGVAFAYKNDGQNPSASFKDRGMACAFSYLKWLCRRNQWDEVLTVCAS
TGDTSAAAALYASYVGAPLKSVVLLPHGKVTPQQLAQPLGSGATVLELPGVFDDCMKVVELLAENYRVALLNSKNSWRIL
GQESYAYEVAQWYGWDMTDQCLFVPIGNAGNVTAIMSGFLKMLDLGMITGLPRIFGVQSEHADPVWRYYDAPAGSRCWQP
VTVQPSVAQAAMIGNPVSFPRVRMLAERFMESGGERAFQVVRVTEQQIMDAMIMANRHGHIACTQGGECLAGLRNARTLG
LVGDHEHAVLDATAHALKFAGFQDMYFNDAFPPEYGVSPDKSLANLPELLLPQSAREGRDVAEFASLGAEAVVQRLKLQK
K
>Mature_480_residues
AHADFPAYRGRMEYVCLDCGARYPGDSLLYTCPQCGGVFLLENLDFARLKERSGQEWRKIFDDRCASRSTALKGIFRYYE
LLAPLLDEDDIVYLGEGITPVVEASAALRDMTGVAFAYKNDGQNPSASFKDRGMACAFSYLKWLCRRNQWDEVLTVCAST
GDTSAAAALYASYVGAPLKSVVLLPHGKVTPQQLAQPLGSGATVLELPGVFDDCMKVVELLAENYRVALLNSKNSWRILG
QESYAYEVAQWYGWDMTDQCLFVPIGNAGNVTAIMSGFLKMLDLGMITGLPRIFGVQSEHADPVWRYYDAPAGSRCWQPV
TVQPSVAQAAMIGNPVSFPRVRMLAERFMESGGERAFQVVRVTEQQIMDAMIMANRHGHIACTQGGECLAGLRNARTLGL
VGDHEHAVLDATAHALKFAGFQDMYFNDAFPPEYGVSPDKSLANLPELLLPQSAREGRDVAEFASLGAEAVVQRLKLQKK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786185, Length=307, Percent_Identity=29.3159609120521, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52939; Mature: 52808

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHADFPAYRGRMEYVCLDCGARYPGDSLLYTCPQCGGVFLLENLDFARLKERSGQEWRK
CCCCCCCHHCCCEEEEEEECCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHCCCHHHHH
IFDDRCASRSTALKGIFRYYELLAPLLDEDDIVYLGEGITPVVEASAALRDMTGVAFAYK
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCEEEEEC
NDGQNPSASFKDRGMACAFSYLKWLCRRNQWDEVLTVCASTGDTSAAAALYASYVGAPLK
CCCCCCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
SVVLLPHGKVTPQQLAQPLGSGATVLELPGVFDDCMKVVELLAENYRVALLNSKNSWRIL
HEEECCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEE
GQESYAYEVAQWYGWDMTDQCLFVPIGNAGNVTAIMSGFLKMLDLGMITGLPRIFGVQSE
CCCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
HADPVWRYYDAPAGSRCWQPVTVQPSVAQAAMIGNPVSFPRVRMLAERFMESGGERAFQV
CCCCHHHEECCCCCCCCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
VRVTEQQIMDAMIMANRHGHIACTQGGECLAGLRNARTLGLVGDHEHAVLDATAHALKFA
HHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHC
GFQDMYFNDAFPPEYGVSPDKSLANLPELLLPQSAREGRDVAEFASLGAEAVVQRLKLQK
CCHHHCCCCCCCCCCCCCCCCHHHHCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCC
K
C
>Mature Secondary Structure 
AHADFPAYRGRMEYVCLDCGARYPGDSLLYTCPQCGGVFLLENLDFARLKERSGQEWRK
CCCCCCHHCCCEEEEEEECCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHCCCHHHHH
IFDDRCASRSTALKGIFRYYELLAPLLDEDDIVYLGEGITPVVEASAALRDMTGVAFAYK
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCEEEEEC
NDGQNPSASFKDRGMACAFSYLKWLCRRNQWDEVLTVCASTGDTSAAAALYASYVGAPLK
CCCCCCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
SVVLLPHGKVTPQQLAQPLGSGATVLELPGVFDDCMKVVELLAENYRVALLNSKNSWRIL
HEEECCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEE
GQESYAYEVAQWYGWDMTDQCLFVPIGNAGNVTAIMSGFLKMLDLGMITGLPRIFGVQSE
CCCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
HADPVWRYYDAPAGSRCWQPVTVQPSVAQAAMIGNPVSFPRVRMLAERFMESGGERAFQV
CCCCHHHEECCCCCCCCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
VRVTEQQIMDAMIMANRHGHIACTQGGECLAGLRNARTLGLVGDHEHAVLDATAHALKFA
HHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHC
GFQDMYFNDAFPPEYGVSPDKSLANLPELLLPQSAREGRDVAEFASLGAEAVVQRLKLQK
CCHHHCCCCCCCCCCCCCCCCHHHHCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]