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The map label for this gene is atoC [H]

Identifier: 220903304

GI number: 220903304

Start: 24135

End: 24542

Strand: Direct

Name: atoC [H]

Synonym: Ddes_0018

Alternate gene names: 220903304

Gene position: 24135-24542 (Clockwise)

Preceding gene: 220903302

Following gene: 220903305

Centisome position: 0.84

GC content: 55.15

Gene sequence:

>408_bases
ATGGGGTTTAAAAAGATCCTTCTGGTTGATGACGAGGAAGAAGTCACACGCATCCTGGCCAAACGGCTGGGCCGCAGGGG
CTACGAATGCGCCACGGCCGCGAATGGGCAACTGGCCCTGAACGCGATGGAAGACACGGCGTATCATGTTGTTATCATGG
ATGTGAAAATGCCTGTTATGGACGGCATGAGCGCCCTGCAAAAAATCCACAGGCTCTGGCCGTGTACGCAGGTCATTCTT
CTTTCCGGACATGCAGATATGCAGTTGGCCGTGCAGGCCATGAGCGAAGGGGCTTTCGGCTATCTGATGAAGCCCGTTGA
CCTCGATGAGCTGCTGTTTAAAATCGAAGATGCCGCAACGCAATGCCGCCTTGAGGCGGAGCAGGGTGGCGCCAATAATC
CGTCTTGA

Upstream 100 bases:

>100_bases
AAAAAGTTAAAATTTTTATGGCCGGAGCCTTGCCCCCCAACGTGTTTGCAGGGTAAAATAAGGACGTTTCTGAACATACT
GAACATGATGGTAGGCGTGT

Downstream 100 bases:

>100_bases
TAGACGTTGACAGGATGTTTTATGACAGTATTTAAAAAAGCAGGGGCCGTAGCCCTTTTGGGCTTGATGACTTTTGGGGG
TTGGGCGCTGCTGGCGCAGC

Product: response regulator receiver protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MGFKKILLVDDEEEVTRILAKRLGRRGYECATAANGQLALNAMEDTAYHVVIMDVKMPVMDGMSALQKIHRLWPCTQVIL
LSGHADMQLAVQAMSEGAFGYLMKPVDLDELLFKIEDAATQCRLEAEQGGANNPS

Sequences:

>Translated_135_residues
MGFKKILLVDDEEEVTRILAKRLGRRGYECATAANGQLALNAMEDTAYHVVIMDVKMPVMDGMSALQKIHRLWPCTQVIL
LSGHADMQLAVQAMSEGAFGYLMKPVDLDELLFKIEDAATQCRLEAEQGGANNPS
>Mature_134_residues
GFKKILLVDDEEEVTRILAKRLGRRGYECATAANGQLALNAMEDTAYHVVIMDVKMPVMDGMSALQKIHRLWPCTQVILL
SGHADMQLAVQAMSEGAFGYLMKPVDLDELLFKIEDAATQCRLEAEQGGANNPS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=41.025641025641, Blast_Score=96, Evalue=7e-22,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=35.3448275862069, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=36.283185840708, Blast_Score=77, Evalue=3e-16,
Organism=Escherichia coli, GI1788905, Length=117, Percent_Identity=37.6068376068376, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 14884; Mature: 14752

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
8.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFKKILLVDDEEEVTRILAKRLGRRGYECATAANGQLALNAMEDTAYHVVIMDVKMPVM
CCCCEEEEECCHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCEEEEEEEEECCCHH
DGMSALQKIHRLWPCTQVILLSGHADMQLAVQAMSEGAFGYLMKPVDLDELLFKIEDAAT
HHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHH
QCRLEAEQGGANNPS
HHEEECCCCCCCCCC
>Mature Secondary Structure 
GFKKILLVDDEEEVTRILAKRLGRRGYECATAANGQLALNAMEDTAYHVVIMDVKMPVM
CCCEEEEECCHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCEEEEEEEEECCCHH
DGMSALQKIHRLWPCTQVILLSGHADMQLAVQAMSEGAFGYLMKPVDLDELLFKIEDAAT
HHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHH
QCRLEAEQGGANNPS
HHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]