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The map label for this gene is gyrA [H]

Identifier: 220903292

GI number: 220903292

Start: 7987

End: 10554

Strand: Direct

Name: gyrA [H]

Synonym: Ddes_0006

Alternate gene names: 220903292

Gene position: 7987-10554 (Clockwise)

Preceding gene: 220903291

Following gene: 220903293

Centisome position: 0.28

GC content: 58.68

Gene sequence:

>2568_bases
GTGGCAGAAATGCAGCAGCCGCAGATAAGCATAGAAACTGAACTCCGCAAGTCGTACCTGGAGTATTCCCTTTCGGTCAT
CATCGGCCGCGCCATTCCTGACGCCCGTGACGGTCTCAAGCCCGTTCACAGGCGCATCATGTTTGCGCAGTACGAGCTTG
CCAACAACTATAACCGTCCGCACAAAAAGTCCGCCCGCATCGTCGGTGACGTGATCGGTAAATATCACCCGCACGGCGAC
TCGGCTGTGTATGATGCCCTGGTGCGTCTGGCGCAGGATTTTTCCATGCGCGACCCCCTGGTGGACGGGCAGGGAAACTT
CGGCTCCATCGACGGTGACGCCCCGGCGGCAATGCGTTACACCGAAGTACGCATGTCCAGGCTGGCCCAGGAATTTCTGG
GCGATCTGGACAAGAACACGGTGGATTTTCGCCCCAACTACGACAATACCTTGCAGGAACCCACGGTTATGCCCAGCAAG
GTTCCCAACCTGCTGCTCAACGGCAGCTCGGGTATTGCCGTGGGCATGGCCACCAATATTCCGCCCCATAATCTTGGCGA
ACTGTGCGATGCCCTGCAACTGCTTCTGGATGATCCCCAGTGCAGCATTGATGACCTTATGGAGCATGTGAAAGGCCCGG
ACTTCCCCACCAGCGGCTATGTTTACGCGGGCAAGGGGCTGTACGACGCCTACCACACCGGACGCGGCACGGTGAAAGTG
CGCGGCCGCATGGAAATCGAAGACCGCAAGAAAAGCGCACAGTCCATCGTCATCAGGGAAATCCCCTATGGGCTGAACAA
GTCTTCTCTGGTAGAAAAGATCGCGGCTCTGGTCAATGACCGCAAGATTGACGGCATTACCGACCTGCGTGACGAATCCG
ACCGCAGGGGCATCCGCGTGGTCATCGATCTCAAGCGGGGAACCATTCCCGAGATCGTCATCAACGCGCTTTACAAATTC
ACGCCGCTGGAATCGAGCTTCGGCATCAATATGCTGGCCGTGGTGGACAACCGTCCGCAGCTTTTGAACCTTAAAAGCGC
GCTTACCTGCTTTGTGGACCACAGGCGTGAGGTGGTTATCCGCCGCACCCGCTATGATCTTGAAAAAGCCGAGGCCCGCG
CCCATATTCTTGAAGGCCTGCGCGTTGCCATCGACAATATTGATGAAGTTGTGGCTCTTATCCGTGCTTCGGCCAGCCCG
GACGAAGCGCGCGCTGCCCTCATGAAGCGCTTTGAGCTTTCCGAACTTCAGGCCAAGGCCATTCTTGAAATGCGTTTGCA
GCGTCTTACGGGCCTGCAGCGTGAAGAACTCATGGCCGAGTACAAGGACCTTCTGCAAAAGATCGAATTCTACCGTTCGA
TTCTTGAAAATACCGAAGTGCTGCGCGGCGAACTCAAGCGCGAGATACGCGAAATCCGCGAAACGTTCGCCACGCCGCGC
CGCACAGAAGTGCTGCGCGAAGCTCTTACCGACATTGACATTGAAGACCTCATTCCTGATGAAGACGTGGTCATCACCCT
GTCGCGTCGCGGCTATATGAAGCGCACCGGGCTTGAAAACTACCAGCAGCAGAAGCGTGGGGGCAAGGGTATCGCCGCCC
TGTATACCTCTGACGATGACTATGTGCAGGAGTTTTTGAGCACTACCAACCATCAGTTCCTGTGCCTCTTCACCAACAAG
GGCCGCATGCACCAGCTCAAGGTGCATCAGGTTCCTGAAGGCAGCCGCACGGCCAAGGGCGTACACATCAACAACCTGCT
GCCTCTTGAAGACGGTGAATGGGTCACAACCGTGCTTGCCCTGCGCGAATTTGCCGAGGACAAGTACTTCCTCTTTGTGA
CCAAGCGCGGCATGGTCAAGCGCTCTTCGGCCTCTCTGTACGCCCGTTGCCGCAAGACCGGACTTATGGCCGTGGGCCTG
CGCGAAGACGACGAGCTTGTGGTGGTGCGCCCCATACGCAACGACAGTCATATTGTGCTGGCTACGGCCGACGGCATAGC
CATACGTTTTTCCTGCAAGGATGTGCGCCCCATGGGCCGTGTGGCCACGGGCGTCAAGGGCATTGCCCTGCGCAGGCAGG
ACTTTGTGGTGGCCGGGGTCATTGTGAAGGAAACGGACCAGACCACCGAAATCATGTCCATTTCCGCCAACGGCTTCGGC
AAGCGTACCAGCATCGAGCTGTATCGCCTGCAATCGCGCGGGGGCAAGGGCATCATCAACTTCAAGGTTACCGGCAAGAC
CGGGCCTGTGGTGGGCGCCATGCCCGTGCGTGATGATGACAGCCTGATCCTGCTCACTTCGGCCAACAAGATTGTGCGCA
TAGGTCTGGATGAAGTACGCAGCAAGGGCCGCGCCACAATGGGCGTGATGCTCGTGCGCCTGGACGAGGGCGCGCATGTG
GTGGGCTTTGACCGCGTGGATGAAGGCGGCCAGACCGGCCGTGACCTGAGCGAAGATATGGACGAGGACGCCGTGCCGGA
AGGCAGCGCGCCCGCGGCTCAGGACGCGCCCTCTTCCGCCCCTGCAGACAGGGGGGCAGGTGAAGGCGGGACAGGCGAAG
ACGCCTGA

Upstream 100 bases:

>100_bases
AGTTAGGGCAGTTCCGTACGGAACTTCGGGGGGCACAGCGTCCCTGAACCGCCGCAGACAGTTCGCATCCACCCAACATC
ATTACTTAGCGAGGCCAGCA

Downstream 100 bases:

>100_bases
GATGGATCTGCATAATGTTTTTCACTGCTGAAAAACGTGGTTTCAGGGGGGCACTGCCCCCCTGTCCACCTGAAGGACGG
CAACGTCCCTCGGGCGGACG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 855; Mature: 854

Protein sequence:

>855_residues
MAEMQQPQISIETELRKSYLEYSLSVIIGRAIPDARDGLKPVHRRIMFAQYELANNYNRPHKKSARIVGDVIGKYHPHGD
SAVYDALVRLAQDFSMRDPLVDGQGNFGSIDGDAPAAMRYTEVRMSRLAQEFLGDLDKNTVDFRPNYDNTLQEPTVMPSK
VPNLLLNGSSGIAVGMATNIPPHNLGELCDALQLLLDDPQCSIDDLMEHVKGPDFPTSGYVYAGKGLYDAYHTGRGTVKV
RGRMEIEDRKKSAQSIVIREIPYGLNKSSLVEKIAALVNDRKIDGITDLRDESDRRGIRVVIDLKRGTIPEIVINALYKF
TPLESSFGINMLAVVDNRPQLLNLKSALTCFVDHRREVVIRRTRYDLEKAEARAHILEGLRVAIDNIDEVVALIRASASP
DEARAALMKRFELSELQAKAILEMRLQRLTGLQREELMAEYKDLLQKIEFYRSILENTEVLRGELKREIREIRETFATPR
RTEVLREALTDIDIEDLIPDEDVVITLSRRGYMKRTGLENYQQQKRGGKGIAALYTSDDDYVQEFLSTTNHQFLCLFTNK
GRMHQLKVHQVPEGSRTAKGVHINNLLPLEDGEWVTTVLALREFAEDKYFLFVTKRGMVKRSSASLYARCRKTGLMAVGL
REDDELVVVRPIRNDSHIVLATADGIAIRFSCKDVRPMGRVATGVKGIALRRQDFVVAGVIVKETDQTTEIMSISANGFG
KRTSIELYRLQSRGGKGIINFKVTGKTGPVVGAMPVRDDDSLILLTSANKIVRIGLDEVRSKGRATMGVMLVRLDEGAHV
VGFDRVDEGGQTGRDLSEDMDEDAVPEGSAPAAQDAPSSAPADRGAGEGGTGEDA

Sequences:

>Translated_855_residues
MAEMQQPQISIETELRKSYLEYSLSVIIGRAIPDARDGLKPVHRRIMFAQYELANNYNRPHKKSARIVGDVIGKYHPHGD
SAVYDALVRLAQDFSMRDPLVDGQGNFGSIDGDAPAAMRYTEVRMSRLAQEFLGDLDKNTVDFRPNYDNTLQEPTVMPSK
VPNLLLNGSSGIAVGMATNIPPHNLGELCDALQLLLDDPQCSIDDLMEHVKGPDFPTSGYVYAGKGLYDAYHTGRGTVKV
RGRMEIEDRKKSAQSIVIREIPYGLNKSSLVEKIAALVNDRKIDGITDLRDESDRRGIRVVIDLKRGTIPEIVINALYKF
TPLESSFGINMLAVVDNRPQLLNLKSALTCFVDHRREVVIRRTRYDLEKAEARAHILEGLRVAIDNIDEVVALIRASASP
DEARAALMKRFELSELQAKAILEMRLQRLTGLQREELMAEYKDLLQKIEFYRSILENTEVLRGELKREIREIRETFATPR
RTEVLREALTDIDIEDLIPDEDVVITLSRRGYMKRTGLENYQQQKRGGKGIAALYTSDDDYVQEFLSTTNHQFLCLFTNK
GRMHQLKVHQVPEGSRTAKGVHINNLLPLEDGEWVTTVLALREFAEDKYFLFVTKRGMVKRSSASLYARCRKTGLMAVGL
REDDELVVVRPIRNDSHIVLATADGIAIRFSCKDVRPMGRVATGVKGIALRRQDFVVAGVIVKETDQTTEIMSISANGFG
KRTSIELYRLQSRGGKGIINFKVTGKTGPVVGAMPVRDDDSLILLTSANKIVRIGLDEVRSKGRATMGVMLVRLDEGAHV
VGFDRVDEGGQTGRDLSEDMDEDAVPEGSAPAAQDAPSSAPADRGAGEGGTGEDA
>Mature_854_residues
AEMQQPQISIETELRKSYLEYSLSVIIGRAIPDARDGLKPVHRRIMFAQYELANNYNRPHKKSARIVGDVIGKYHPHGDS
AVYDALVRLAQDFSMRDPLVDGQGNFGSIDGDAPAAMRYTEVRMSRLAQEFLGDLDKNTVDFRPNYDNTLQEPTVMPSKV
PNLLLNGSSGIAVGMATNIPPHNLGELCDALQLLLDDPQCSIDDLMEHVKGPDFPTSGYVYAGKGLYDAYHTGRGTVKVR
GRMEIEDRKKSAQSIVIREIPYGLNKSSLVEKIAALVNDRKIDGITDLRDESDRRGIRVVIDLKRGTIPEIVINALYKFT
PLESSFGINMLAVVDNRPQLLNLKSALTCFVDHRREVVIRRTRYDLEKAEARAHILEGLRVAIDNIDEVVALIRASASPD
EARAALMKRFELSELQAKAILEMRLQRLTGLQREELMAEYKDLLQKIEFYRSILENTEVLRGELKREIREIRETFATPRR
TEVLREALTDIDIEDLIPDEDVVITLSRRGYMKRTGLENYQQQKRGGKGIAALYTSDDDYVQEFLSTTNHQFLCLFTNKG
RMHQLKVHQVPEGSRTAKGVHINNLLPLEDGEWVTTVLALREFAEDKYFLFVTKRGMVKRSSASLYARCRKTGLMAVGLR
EDDELVVVRPIRNDSHIVLATADGIAIRFSCKDVRPMGRVATGVKGIALRRQDFVVAGVIVKETDQTTEIMSISANGFGK
RTSIELYRLQSRGGKGIINFKVTGKTGPVVGAMPVRDDDSLILLTSANKIVRIGLDEVRSKGRATMGVMLVRLDEGAHVV
GFDRVDEGGQTGRDLSEDMDEDAVPEGSAPAAQDAPSSAPADRGAGEGGTGEDA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=319, Percent_Identity=24.7648902821317, Blast_Score=77, Evalue=8e-14,
Organism=Homo sapiens, GI19913406, Length=325, Percent_Identity=24, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1788562, Length=835, Percent_Identity=47.185628742515, Blast_Score=767, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=520, Percent_Identity=42.1153846153846, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645657, Length=376, Percent_Identity=24.7340425531915, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=362, Percent_Identity=25.9668508287293, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=375, Percent_Identity=24, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=197, Percent_Identity=26.9035532994924, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136538, Length=359, Percent_Identity=25.0696378830084, Blast_Score=78, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95197; Mature: 95066

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMQQPQISIETELRKSYLEYSLSVIIGRAIPDARDGLKPVHRRIMFAQYELANNYNRP
CCCCCCCCEEHHHHHHHHHHHHHHHHHEECCCCCHHCCHHHHHHHHHHHHHHHHCCCCCC
HKKSARIVGDVIGKYHPHGDSAVYDALVRLAQDFSMRDPLVDGQGNFGSIDGDAPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
TEVRMSRLAQEFLGDLDKNTVDFRPNYDNTLQEPTVMPSKVPNLLLNGSSGIAVGMATNI
HHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCC
PPHNLGELCDALQLLLDDPQCSIDDLMEHVKGPDFPTSGYVYAGKGLYDAYHTGRGTVKV
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCHHHHHHCCCCEEEE
RGRMEIEDRKKSAQSIVIREIPYGLNKSSLVEKIAALVNDRKIDGITDLRDESDRRGIRV
EEEECHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCEEE
VIDLKRGTIPEIVINALYKFTPLESSFGINMLAVVDNRPQLLNLKSALTCFVDHRREVVI
EEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHHH
RRTRYDLEKAEARAHILEGLRVAIDNIDEVVALIRASASPDEARAALMKRFELSELQAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ILEMRLQRLTGLQREELMAEYKDLLQKIEFYRSILENTEVLRGELKREIREIRETFATPR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RTEVLREALTDIDIEDLIPDEDVVITLSRRGYMKRTGLENYQQQKRGGKGIAALYTSDDD
HHHHHHHHHHCCCHHHCCCCCCEEEEECCCCCHHHCCHHHHHHHHCCCCCEEEEEECCHH
YVQEFLSTTNHQFLCLFTNKGRMHQLKVHQVPEGSRTAKGVHINNLLPLEDGEWVTTVLA
HHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCEEECCEECCCCCCHHHHHHH
LREFAEDKYFLFVTKRGMVKRSSASLYARCRKTGLMAVGLREDDELVVVRPIRNDSHIVL
HHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCEEEE
ATADGIAIRFSCKDVRPMGRVATGVKGIALRRQDFVVAGVIVKETDQTTEIMSISANGFG
EECCCEEEEEECCCCCCHHHHHCCCHHEEEECCCEEEEEEEEECCCCCEEEEEEECCCCC
KRTSIELYRLQSRGGKGIINFKVTGKTGPVVGAMPVRDDDSLILLTSANKIVRIGLDEVR
CCCEEEEEEEECCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCEEEECHHHHH
SKGRATMGVMLVRLDEGAHVVGFDRVDEGGQTGRDLSEDMDEDAVPEGSAPAAQDAPSSA
CCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
PADRGAGEGGTGEDA
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEMQQPQISIETELRKSYLEYSLSVIIGRAIPDARDGLKPVHRRIMFAQYELANNYNRP
CCCCCCCEEHHHHHHHHHHHHHHHHHEECCCCCHHCCHHHHHHHHHHHHHHHHCCCCCC
HKKSARIVGDVIGKYHPHGDSAVYDALVRLAQDFSMRDPLVDGQGNFGSIDGDAPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
TEVRMSRLAQEFLGDLDKNTVDFRPNYDNTLQEPTVMPSKVPNLLLNGSSGIAVGMATNI
HHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCC
PPHNLGELCDALQLLLDDPQCSIDDLMEHVKGPDFPTSGYVYAGKGLYDAYHTGRGTVKV
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCHHHHHHCCCCEEEE
RGRMEIEDRKKSAQSIVIREIPYGLNKSSLVEKIAALVNDRKIDGITDLRDESDRRGIRV
EEEECHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCEEE
VIDLKRGTIPEIVINALYKFTPLESSFGINMLAVVDNRPQLLNLKSALTCFVDHRREVVI
EEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHHH
RRTRYDLEKAEARAHILEGLRVAIDNIDEVVALIRASASPDEARAALMKRFELSELQAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ILEMRLQRLTGLQREELMAEYKDLLQKIEFYRSILENTEVLRGELKREIREIRETFATPR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RTEVLREALTDIDIEDLIPDEDVVITLSRRGYMKRTGLENYQQQKRGGKGIAALYTSDDD
HHHHHHHHHHCCCHHHCCCCCCEEEEECCCCCHHHCCHHHHHHHHCCCCCEEEEEECCHH
YVQEFLSTTNHQFLCLFTNKGRMHQLKVHQVPEGSRTAKGVHINNLLPLEDGEWVTTVLA
HHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCEEECCEECCCCCCHHHHHHH
LREFAEDKYFLFVTKRGMVKRSSASLYARCRKTGLMAVGLREDDELVVVRPIRNDSHIVL
HHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCEEEE
ATADGIAIRFSCKDVRPMGRVATGVKGIALRRQDFVVAGVIVKETDQTTEIMSISANGFG
EECCCEEEEEECCCCCCHHHHHCCCHHEEEECCCEEEEEEEEECCCCCEEEEEEECCCCC
KRTSIELYRLQSRGGKGIINFKVTGKTGPVVGAMPVRDDDSLILLTSANKIVRIGLDEVR
CCCEEEEEEEECCCCCEEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCEEEECHHHHH
SKGRATMGVMLVRLDEGAHVVGFDRVDEGGQTGRDLSEDMDEDAVPEGSAPAAQDAPSSA
CCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
PADRGAGEGGTGEDA
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]