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The map label for this gene is hutH [H]

Identifier: 21911315

GI number: 21911315

Start: 1803106

End: 1804647

Strand: Direct

Name: hutH [H]

Synonym: SpyM3_1779

Alternate gene names: 21911315

Gene position: 1803106-1804647 (Clockwise)

Preceding gene: 21911314

Following gene: 21911316

Centisome position: 94.87

GC content: 45.53

Gene sequence:

>1542_bases
ATGACAAGAGTGATTAATTTAGATGGCGAAAGCCTTACTATCGAAGACGTGATTGCGATTGCTCGCCAAGGCGTAGCCTG
TCGCATTGATGATAGTGCTATTGAAGCTGTGAATGCCTCTCGTAAAATTGTTGATGACATTGTCAGTGAAAAACGGGTGG
TTTACGGGGTGACCACTGGTTTTGGATCCCTTTGTAACGTAAGCATCTCACCAGAAGATACAGTTCAACTCCAAGAAAAT
TTGATTCGTACCCATGCTAGTGGATTTGGTGACCCATTGCCAGAAGATGCCGTGCGCGCTATCATGCTGATCCGTATCAA
CTCTCTCGTCAAAGGGTATTCTGGTATTCGTCTATCCACCATTGAAAAACTGTTGGAACTGCTCAATAAAGGGGTTCATC
CTTACATTCCTGAAAAAGGGTCTCTAGGGGCTTCAGGAGATTTGGCGCCGCTTGCTCACATGGTGCTTCCTATGCTTGGT
CTAGGGAAAGCTTACTACAAAGGAGAGCTTCTTTCTGGTCAAGAAGCTCTTGATAAAGCTGGTATTGACAAGATTTCTTT
AGCCGCTAAAGAAGGACTCGCCCTTATCAACGGAACAACTGTTCTCACTGCAATCGGTGCCCTTGCAACCTATGACGCCA
TTCAATTATTGAAACTGTCAGACCTAGCTGGTGCCCTATCCCTTGAAGTGCATAACGGGATTACTAGTCCATTTGAAGAA
AACCTTCACACCATTCGCCCACAAAGCGGCCAGTTGGCAACAGCCCGCAATATCCGAAACCTCCATGAAGGCAGCCAAAA
CACAACCGTAGCTACTCAATCTCGTGTGCAAGACCCTTACACCTTGCGCTGCATCCCTCAAATTCATGGGGCTAGCAAAG
ACAGTATCGCCTATGTCAAATCCAAAGTTGACATTGAAATCAATTCTGTCACAGATAATCCAATTATCTGTAAAGATGGC
CACGTTATTTCAGGAGGTAACTTCCACGGAGAACCAATGGCACAGCCATTTGACTTCTTAGGCATCGCCATTTCTGAAAT
TGGAAATGTTTCTGAACGCCGCGTGGAACGTTTGGTCAATAGCCAGCTCAGCAAATTGCCATCCTTTCTTGTCAAATACC
CAGGTCTCAATTCAGGCTTTATGATTACCCAGTACGCCTGTGCCTCTCTTGCTTCTGAAAACAAGGTTTTGGCACATCCA
GCCAGTGTGGATTCTATCCCATCTTGTGAGAACCAAGAAGACTTTGTCAGCATGGGCACCACCGCTGCTCGCAAGGCCTT
TGAAATCCTTAAAAATTCTCACCGCATCGTGGCTACTGAAATCATGGCAGCCTGCCAAGCTCTTGATCTCAAATCTGAAA
ATCATGAACTAGGTAAAGGGACTAAGGTTGCCTACGATCTCTTCCGCAAGGAAGTCAACTTTATCGAACACGATAAACAC
ATCGAAATCTACGATGAACTAAACAAGGCATCAACAGTCATTGAAGACCCAAGCTTCCTCGAAGCGGTTGAGCAGGCAGT
TGAGTTGAGTATCCAATTTTAG

Upstream 100 bases:

>100_bases
GTTGGTGTCATCATTGCAAGTAGTGTGTACTACCTTATGCACGGACGTAACCACCAAATGGACCAAATGCCCCCTAAGGA
ACAAATCTAGGAGAAAAACT

Downstream 100 bases:

>100_bases
TGAATAAGGTACTTCTTTAACTGAGAGGGGCTGTGGCAGAGGTCATGGCCTCTTTAGACTAACTAACTGGGACCAAAAGC
AGACGATTTTATTGCTCTGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTRVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQEN
LIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
NLHTIRPQSGQLATARNIRNLHEGSQNTTVATQSRVQDPYTLRCIPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDG
HVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHP
ASVDSIPSCENQEDFVSMGTTAARKAFEILKNSHRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF

Sequences:

>Translated_513_residues
MTRVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQEN
LIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
NLHTIRPQSGQLATARNIRNLHEGSQNTTVATQSRVQDPYTLRCIPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDG
HVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHP
ASVDSIPSCENQEDFVSMGTTAARKAFEILKNSHRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
>Mature_512_residues
TRVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQENL
IRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGL
GKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEEN
LHTIRPQSGQLATARNIRNLHEGSQNTTVATQSRVQDPYTLRCIPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDGH
VISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPA
SVDSIPSCENQEDFVSMGTTAARKAFEILKNSHRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKHI
EIYDELNKASTVIEDPSFLEAVEQAVELSIQF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=486, Percent_Identity=43.0041152263374, Blast_Score=407, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=509, Percent_Identity=42.4361493123772, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55470; Mature: 55339

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTG
CCEEEECCCCEEEHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
FGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLST
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
IEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKA
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHC
GIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
CCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
NLHTIRPQSGQLATARNIRNLHEGSQNTTVATQSRVQDPYTLRCIPQIHGASKDSIAYVK
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEHHHCCCCCCCHHEEE
SKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVN
EEEEEEEEEECCCCEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
SQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHCH
TAARKAFEILKNSHRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
EEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTG
CEEEECCCCEEEHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
FGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLST
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
IEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKA
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHC
GIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
CCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
NLHTIRPQSGQLATARNIRNLHEGSQNTTVATQSRVQDPYTLRCIPQIHGASKDSIAYVK
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEHHHCCCCCCCHHEEE
SKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVN
EEEEEEEEEECCCCEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
SQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHCH
TAARKAFEILKNSHRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
EEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]