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The map label for this gene is cadA [H]

Identifier: 21910629

GI number: 21910629

Start: 1135351

End: 1137213

Strand: Reverse

Name: cadA [H]

Synonym: SpyM3_1093

Alternate gene names: 21910629

Gene position: 1137213-1135351 (Counterclockwise)

Preceding gene: 21910630

Following gene: 21910628

Centisome position: 59.84

GC content: 41.01

Gene sequence:

>1863_bases
ATGACAATCAGACAATGGATGGCAGACCATCTTCATTTGATGGAGACTTTAGCGTGTTTGGTATTAATAATAATTGGCCT
AGCCTTTTTACACTCATTTCCACAAGTGGCTTCCGCTATTTTCATTACAGCCTTCTTGATTGGAGGATATGCGTCTGCAA
AAACGGGTATATTGGATTTGGTGAAGAACAAACACTTGTCAGTGGATATTTTGATGATTTTGGCAGCTATCGGTGCTGGA
ATTATCGGCTATTGGCTGGAGGGTGCTCTGCTTATTTTTATCTTTTCGTTGTCCAATACGCTTGAAGAAATGGCCATGGA
AAAAAGTAAGGATGCTATTTCAGCCTTGATGTCCTTGACGCCAGATACAGCTCGTCAATACCAAGAAGATGGCCATATTT
TAGAAGTTGAGACCAGATCCTTGAGTGTTGGTGACCGTTTACAAGTTCGTAAAGGCGAAGCTGTTCCAATTGACGGGCAG
TTGCTTAGTCCTTTTGGTCAATTTGATGAATCTATGGTCACTGGTGAGCCTATCACTGTTGATAAGGCAGAAGGCCAGGA
TCTGATTGGGGGAACCATTAACCAAGGACAAACCATAGATATGTTGGTTACTATTGAAAATGACGATACTCTCTTTGCCA
AGATTATTAATCTGGTGGAATCTGCCCAAGAAAAGAAAAGCAAAACTGCCACCTTTATCGAAAGCTTAGAAGATGGTTAT
GTCAAATTTGTGCTCGTCCTTATTCCTGCCTTTATCCTCTTTAGCCACTTTGTGCTTTCTTGGACTTGGTTGGCTGCTTT
TTACCGAGGGATGATTCTCTTAACAGTAGCTTCACCATGTGCCCTAATTGCCAGTTCCACACCTGCTAGCTTGGCTGCTA
TTTCTCGTGCAGCCAGAAAGGGATTGATTATCAAAGGAGGGGATATTGTCGATAACATGGGAGATATTAAGGCTGTTGTC
ATGGATAAAACGGGAACGCTCACCCAAGGAAAACCTTCTGTTGTGAATGCTCATTATTTGGAAGATGAGTTGCTCGTGAA
TAGACTGGTAAAAGGAGCAGAGGCTGCTAGTACCCATCCTATATCTAAAGCCCTTCTTGAATACACTGAAGCAGTAGAAG
CACTGAATTTTGACCAATTAGAAGAGATTGCTGGGAAAGGATTCCAAGGGCTCTATCAAGGTCAAGAATGGCGCATTGGG
AAGAAATCCTTTATTTTAGAGATGGTGCCAGATCTTTCAGCTTTTGAAGAAACGATTCAGGTAGAAGAAAGTCAAGGGAA
AACTCTTATCTTTGTTTCTCGCGACAACCAACTAGTAGCCTACTACGCTTTGTTAGATGACATCAAATTAGAGTCAAAAC
GTGCCATTGAAGCTCTTCATGCTATGGGAATCAAGACGGTCATGTTAACAGGGGACCAAGAACGAACTGCCAATTATGTG
GCACAAAAACTTGGTATTGATGAAGTGGTAGCCAACTGTATGCCTCAAGATAAGGTGGCTAAGTTAGCAGAATTAAAGAC
CAAATATGGTTTTGTGGCCATGGTAGGAGATGGTATTAATGATGCTCCTGCCCTTGCTCAAGCAGATGTTTCTTATGCTA
TTGGATCAGGAACAGATATTGCAATGGAAAGTGCAGACAGTGTGATTATGGATGACTTGACTCGTATTCCATTTTCGATT
CAACTTTCCCGCAAAATGAAGACCATTATCAAACAAAATATTGTTTTTGCCTTATCTGTGATTACCTTATTGATTTTAGC
CAATGTTTTTCAGGTAGTTAACTTGCCGCTTGGTGTTGTTGGACACGAAGGCTCAACGATTTTAGTGATTTTAAATGGCT
TGCGTTTACTTTCTTTTAAATAA

Upstream 100 bases:

>100_bases
TATTTAGAATGTTTCTAAATTACTTGACTTATTTATTTAGAATTATTATAATTAATATATCTTAAAGATTGAATAACTTT
TAATTGCGAGGGAACTAAAA

Downstream 100 bases:

>100_bases
TTTAGAAACTTGCTTGAAAACTTGAAAGTGTTTATAATAATACTAAGACTTATGAAAGAGAAAACCGCCGTATGTTTACT
ATTATGATCATTGGTTTAGC

Product: putative heavy metal/cadmium-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAG
IIGYWLEGALLIFIFSLSNTLEEMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQ
LLSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVV
MDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEAVEALNFDQLEEIAGKGFQGLYQGQEWRIG
KKSFILEMVPDLSAFEETIQVEESQGKTLIFVSRDNQLVAYYALLDDIKLESKRAIEALHAMGIKTVMLTGDQERTANYV
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSI
QLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK

Sequences:

>Translated_620_residues
MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAG
IIGYWLEGALLIFIFSLSNTLEEMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQ
LLSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVV
MDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEAVEALNFDQLEEIAGKGFQGLYQGQEWRIG
KKSFILEMVPDLSAFEETIQVEESQGKTLIFVSRDNQLVAYYALLDDIKLESKRAIEALHAMGIKTVMLTGDQERTANYV
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSI
QLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK
>Mature_619_residues
TIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDLVKNKHLSVDILMILAAIGAGI
IGYWLEGALLIFIFSLSNTLEEMAMEKSKDAISALMSLTPDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQL
LSPFGQFDESMVTGEPITVDKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGYV
KFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARKGLIIKGGDIVDNMGDIKAVVM
DKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHPISKALLEYTEAVEALNFDQLEEIAGKGFQGLYQGQEWRIGK
KSFILEMVPDLSAFEETIQVEESQGKTLIFVSRDNQLVAYYALLDDIKLESKRAIEALHAMGIKTVMLTGDQERTANYVA
QKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDIAMESADSVIMDDLTRIPFSIQ
LSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVVGHEGSTILVILNGLRLLSFK

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=585, Percent_Identity=31.7948717948718, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI115529486, Length=604, Percent_Identity=29.9668874172185, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI55743073, Length=546, Percent_Identity=31.8681318681319, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI51944966, Length=310, Percent_Identity=26.4516129032258, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI22748667, Length=245, Percent_Identity=27.3469387755102, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI48762689, Length=184, Percent_Identity=29.8913043478261, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI48762687, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI48762685, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI48762691, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4502271, Length=311, Percent_Identity=24.7588424437299, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI237681111, Length=306, Percent_Identity=25.8169934640523, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI237681109, Length=306, Percent_Identity=25.8169934640523, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI21361181, Length=306, Percent_Identity=25.8169934640523, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789879, Length=625, Percent_Identity=33.92, Blast_Score=314, Evalue=1e-86,
Organism=Escherichia coli, GI1786691, Length=550, Percent_Identity=32.5454545454545, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI1786914, Length=508, Percent_Identity=27.1653543307087, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI2367363, Length=591, Percent_Identity=25.5499153976311, Blast_Score=109, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17556548, Length=193, Percent_Identity=37.8238341968912, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17559224, Length=271, Percent_Identity=26.9372693726937, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320475, Length=561, Percent_Identity=30.6595365418895, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=609, Percent_Identity=24.9589490968801, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321430, Length=528, Percent_Identity=25.1893939393939, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6325221, Length=528, Percent_Identity=24.6212121212121, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320243, Length=197, Percent_Identity=30.4568527918782, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320244, Length=197, Percent_Identity=30.4568527918782, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320245, Length=197, Percent_Identity=29.9492385786802, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321271, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321432, Length=188, Percent_Identity=35.1063829787234, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221329854, Length=190, Percent_Identity=38.9473684210526, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 67422; Mature: 67291

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VKNKHLSVDILMILAAIGAGIIGYWLEGALLIFIFSLSNTLEEMAMEKSKDAISALMSLT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQLLSPFGQFDESMVTGEPITV
CHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHCCHHHHCCCCCCCCCEEE
DKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
ECCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCHHHHCCCCCHHHHHHHHHHHC
GLIIKGGDIVDNMGDIKAVVMDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHP
CEEEECCCHHCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCH
ISKALLEYTEAVEALNFDQLEEIAGKGFQGLYQGQEWRIGKKSFILEMVPDLSAFEETIQ
HHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHH
VEESQGKTLIFVSRDNQLVAYYALLDDIKLESKRAIEALHAMGIKTVMLTGDQERTANYV
HHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDI
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHCCCCEECCCCCCH
AMESADSVIMDDLTRIPFSIQLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVV
HHHCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GHEGSTILVILNGLRLLSFK
CCCCCEEEEEEECCCHHCCC
>Mature Secondary Structure 
TIRQWMADHLHLMETLACLVLIIIGLAFLHSFPQVASAIFITAFLIGGYASAKTGILDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VKNKHLSVDILMILAAIGAGIIGYWLEGALLIFIFSLSNTLEEMAMEKSKDAISALMSLT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDTARQYQEDGHILEVETRSLSVGDRLQVRKGEAVPIDGQLLSPFGQFDESMVTGEPITV
CHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHCCHHHHCCCCCCCCCEEE
DKAEGQDLIGGTINQGQTIDMLVTIENDDTLFAKIINLVESAQEKKSKTATFIESLEDGY
ECCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKFVLVLIPAFILFSHFVLSWTWLAAFYRGMILLTVASPCALIASSTPASLAAISRAARK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCHHHHCCCCCHHHHHHHHHHHC
GLIIKGGDIVDNMGDIKAVVMDKTGTLTQGKPSVVNAHYLEDELLVNRLVKGAEAASTHP
CEEEECCCHHCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCH
ISKALLEYTEAVEALNFDQLEEIAGKGFQGLYQGQEWRIGKKSFILEMVPDLSAFEETIQ
HHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHH
VEESQGKTLIFVSRDNQLVAYYALLDDIKLESKRAIEALHAMGIKTVMLTGDQERTANYV
HHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AQKLGIDEVVANCMPQDKVAKLAELKTKYGFVAMVGDGINDAPALAQADVSYAIGSGTDI
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHCCCCEECCCCCCH
AMESADSVIMDDLTRIPFSIQLSRKMKTIIKQNIVFALSVITLLILANVFQVVNLPLGVV
HHHCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GHEGSTILVILNGLRLLSFK
CCCCCEEEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]