| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
Click here to switch to the map view.
The map label for this gene is murF [H]
Identifier: 21910619
GI number: 21910619
Start: 1126840
End: 1128207
Strand: Reverse
Name: murF [H]
Synonym: SpyM3_1083
Alternate gene names: 21910619
Gene position: 1128207-1126840 (Counterclockwise)
Preceding gene: 21910620
Following gene: 21910618
Centisome position: 59.36
GC content: 39.69
Gene sequence:
>1368_bases ATGAAATTAACCTTACACGAAGTGGCTAAAATAGTTGACGCCCAAAATAATGTGTCTGACTTAGACGACGTTCCTCTGCA TCACATTGAATTTGATAGCCGAAAGATTACAAAAGGAGACCTCTTTTTACCCTTAAAAGGTCAAAGGAATGGTCATGAGT TTATTGATTTAGCCTTTCAAAATGGAGCTGTCGCTACTTTTTCAGAAAAAGAATTGCCGGGGAAACCTCACCTTCTTGTT GAAGACTGCCTAAAAGCTTTTCAAAAGCTAGCCCATTATTATATTGATAAGATGCGCGTGGATGTTATTGCTGTGACAGG CTCAAATGGTAAAACTTCCACCAAAGATATGATAGGAGCTGTCCTATCAACCACTTACAAAACTTACAAAACGCAAGGAA ATTACAATAATGAGATTGGTTTGCCTTACACCGTTCTCCACATGCCTGACGATACGGAAAAAATTGTTCTTGAAATGGGA CAAGATCACATGGGAGATATTCGTCTCCTCTCTGAAATTGCAAGACCCCGTATTGCTGTTTTAACTCTGGTAGGCGAAGC CCATTTAGAATATTTTGGGTCACGTGACAAGATTGCTCAAGGGAAAATGCAAATTGTTGATGGAATGGATTCAAATGGCA TTTTAATTGCCCCAGGTGATTCGATTATCGATCCTTATCTTCCAGAAAACCAGATGGTCATTCGATTTGGCGACCACCAA GAATTGAATGTTACTGATATTCGAGAAGAAAAAGATAGCTTAACGTTTACAACAAATGTGTTAGCAACACCTGTGTCCCT ACCTCTACCAGGAAAATACAACGCGACCAATGCTATGGTAGCAGCCTATGTTGGCAAATTGTTGGCAGTAGCAGATGAGG ATATTATCGAGGCGTTAGAGTCTGTTCAACTCACTGCTAATCGTACAGAATGGAAAAAAGCTGCTAATGGTGCTGACATC TTATCAGATGTTTACAATGCCAATCCGACAGCCATGCGCCTGATTTTAGAAACCTTTGCTAACATAGCAAAGAACCCCGG TGGAAAAAAGATTGCAGTGCTAGCTGACATGAAAGAATTAGGACCAGATTCTGTTGCCCTACATTCGCAGTTAATCAAAC AATTGTCACCTGATCGCATTGACCAACTTGTTTTTTATGGTGATGATATTCAAGAGTTAGCCCAATTAGCACATGAGTTT TATCCTGAAGGACATGTTCAGTTCTTCCAAAAAAATCAGCAAGAAGATCAGTTTGAAGACATGGTAAGACAGGTGCAACA ATTACTTGCTCCCTCTGACCAAATTCTTTTAAAAGGGAGTAACTCAATGGGGCTGGCTAAATTGGTCAATCATTTAGTTG AAAATTAA
Upstream 100 bases:
>100_bases GAGCCATTAAGGGAGTTTGACATTTTAGAAATTTTTCTAATGTTTTGTGCTATAATAGATAGGACATCGTAAATACTAGT GTTCTTAGAAAGAAAACAAA
Downstream 100 bases:
>100_bases AGTGAAGACTTACCTTAGCCTTACTTTTTAGAAAAAGCACAGAGAAGGGCTTGTTCTCTCATAAAGATTAAGGTATAATG AAAAAACGTAGAAAGGGATG
Product: putative D-Ala-D-Ala adding enzyme
Products: NA
Alternate protein names: D-alanyl-D-alanine-adding enzyme; UDP-MurNAc-pentapeptide synthetase [H]
Number of amino acids: Translated: 455; Mature: 455
Protein sequence:
>455_residues MKLTLHEVAKIVDAQNNVSDLDDVPLHHIEFDSRKITKGDLFLPLKGQRNGHEFIDLAFQNGAVATFSEKELPGKPHLLV EDCLKAFQKLAHYYIDKMRVDVIAVTGSNGKTSTKDMIGAVLSTTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMG QDHMGDIRLLSEIARPRIAVLTLVGEAHLEYFGSRDKIAQGKMQIVDGMDSNGILIAPGDSIIDPYLPENQMVIRFGDHQ ELNVTDIREEKDSLTFTTNVLATPVSLPLPGKYNATNAMVAAYVGKLLAVADEDIIEALESVQLTANRTEWKKAANGADI LSDVYNANPTAMRLILETFANIAKNPGGKKIAVLADMKELGPDSVALHSQLIKQLSPDRIDQLVFYGDDIQELAQLAHEF YPEGHVQFFQKNQQEDQFEDMVRQVQQLLAPSDQILLKGSNSMGLAKLVNHLVEN
Sequences:
>Translated_455_residues MKLTLHEVAKIVDAQNNVSDLDDVPLHHIEFDSRKITKGDLFLPLKGQRNGHEFIDLAFQNGAVATFSEKELPGKPHLLV EDCLKAFQKLAHYYIDKMRVDVIAVTGSNGKTSTKDMIGAVLSTTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMG QDHMGDIRLLSEIARPRIAVLTLVGEAHLEYFGSRDKIAQGKMQIVDGMDSNGILIAPGDSIIDPYLPENQMVIRFGDHQ ELNVTDIREEKDSLTFTTNVLATPVSLPLPGKYNATNAMVAAYVGKLLAVADEDIIEALESVQLTANRTEWKKAANGADI LSDVYNANPTAMRLILETFANIAKNPGGKKIAVLADMKELGPDSVALHSQLIKQLSPDRIDQLVFYGDDIQELAQLAHEF YPEGHVQFFQKNQQEDQFEDMVRQVQQLLAPSDQILLKGSNSMGLAKLVNHLVEN >Mature_455_residues MKLTLHEVAKIVDAQNNVSDLDDVPLHHIEFDSRKITKGDLFLPLKGQRNGHEFIDLAFQNGAVATFSEKELPGKPHLLV EDCLKAFQKLAHYYIDKMRVDVIAVTGSNGKTSTKDMIGAVLSTTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMG QDHMGDIRLLSEIARPRIAVLTLVGEAHLEYFGSRDKIAQGKMQIVDGMDSNGILIAPGDSIIDPYLPENQMVIRFGDHQ ELNVTDIREEKDSLTFTTNVLATPVSLPLPGKYNATNAMVAAYVGKLLAVADEDIIEALESVQLTANRTEWKKAANGADI LSDVYNANPTAMRLILETFANIAKNPGGKKIAVLADMKELGPDSVALHSQLIKQLSPDRIDQLVFYGDDIQELAQLAHEF YPEGHVQFFQKNQQEDQFEDMVRQVQQLLAPSDQILLKGSNSMGLAKLVNHLVEN
Specific function: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein [H]
COG id: COG0770
COG function: function code M; UDP-N-acetylmuramyl pentapeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family [H]
Homologues:
Organism=Escherichia coli, GI1786274, Length=453, Percent_Identity=31.7880794701987, Blast_Score=173, Evalue=2e-44,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005863 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.10 [H]
Molecular weight: Translated: 50504; Mature: 50504
Theoretical pI: Translated: 4.89; Mature: 4.89
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLTLHEVAKIVDAQNNVSDLDDVPLHHIEFDSRKITKGDLFLPLKGQRNGHEFIDLAFQ CCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEECCCCEEEEECCCCCCCCEEEEEEC NGAVATFSEKELPGKPHLLVEDCLKAFQKLAHYYIDKMRVDVIAVTGSNGKTSTKDMIGA CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHH VLSTTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMGQDHMGDIRLLSEIARPRIAV HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEE LTLVGEAHLEYFGSRDKIAQGKMQIVDGMDSNGILIAPGDSIIDPYLPENQMVIRFGDHQ EEEHHHHHHHHCCCCCHHHCCCCCEECCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCC ELNVTDIREEKDSLTFTTNVLATPVSLPLPGKYNATNAMVAAYVGKLLAVADEDIIEALE CCCHHHHHHCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH SVQLTANRTEWKKAANGADILSDVYNANPTAMRLILETFANIAKNPGGKKIAVLADMKEL HHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHC GPDSVALHSQLIKQLSPDRIDQLVFYGDDIQELAQLAHEFYPEGHVQFFQKNQQEDQFED CCCHHHHHHHHHHHCCHHHHHHEEEECCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHH MVRQVQQLLAPSDQILLKGSNSMGLAKLVNHLVEN HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCC >Mature Secondary Structure MKLTLHEVAKIVDAQNNVSDLDDVPLHHIEFDSRKITKGDLFLPLKGQRNGHEFIDLAFQ CCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEECCCCEEEEECCCCCCCCEEEEEEC NGAVATFSEKELPGKPHLLVEDCLKAFQKLAHYYIDKMRVDVIAVTGSNGKTSTKDMIGA CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHH VLSTTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMGQDHMGDIRLLSEIARPRIAV HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEE LTLVGEAHLEYFGSRDKIAQGKMQIVDGMDSNGILIAPGDSIIDPYLPENQMVIRFGDHQ EEEHHHHHHHHCCCCCHHHCCCCCEECCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCC ELNVTDIREEKDSLTFTTNVLATPVSLPLPGKYNATNAMVAAYVGKLLAVADEDIIEALE CCCHHHHHHCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH SVQLTANRTEWKKAANGADILSDVYNANPTAMRLILETFANIAKNPGGKKIAVLADMKEL HHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHC GPDSVALHSQLIKQLSPDRIDQLVFYGDDIQELAQLAHEFYPEGHVQFFQKNQQEDQFED CCCHHHHHHHHHHHCCHHHHHHEEEECCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHH MVRQVQQLLAPSDQILLKGSNSMGLAKLVNHLVEN HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9384377 [H]