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The map label for this gene is mvaD

Identifier: 21910132

GI number: 21910132

Start: 655811

End: 656674

Strand: Direct

Name: mvaD

Synonym: SpyM3_0596

Alternate gene names: NA

Gene position: 655811-656674 (Clockwise)

Preceding gene: 21910131

Following gene: 21910133

Centisome position: 34.51

GC content: 40.86

Gene sequence:

>864_bases
ATGATTCCTTCGACCTCTAGCATTTCTTTGACTTTGGAAAACATGTTCACCACAACCAGCGTTTCCTTCTTACCAGATAC
TGCAACCAGTGATCAGTTTTACATTAACGGTGTCTTGCAAAATGACGAAGAACATACCAAAATTTCTACTATCATTGACC
AATTTCGCCAACCTGGTCAGGCTTTTGTAAAGATGGAAACTCAAAATAATATGCCAACAGCTGCAGGTTTATCATCAAGT
TCCAGTGGCTTATCAGCCTTGGTTAAAGCCTGTGATCAATTATTTGACACTCAGCTAGATCAGAAAGCTTTAGCTCAAAA
GGCCAAGTTCGCCTCAGGATCATCTTCTCGTTCTTTTTTTGGCCCAGTTGCTGCTTGGGACAAAGATAGTGGTGCTATTT
ACAAGGTTGAGACTGACTTGAAAATGGCCATGATTATGCTGGTCTTAAATGCTGCGAAAAAGCCAATTTCTAGCCGAGAG
GGCATGAAGTTATGCCGCGATACCTCAACTACATTTGATGAATGGGTAGAACAATCGGCAATCGATTACCAACATATGCT
TACCTATCTCAAAACTAATAATTTTGAGAAAGTTGGTCAGTTAACAGAAGCTAATGCCTTGGCCATGCATGCCACGACAA
AGACAGCCAATCCTCCCTTTTCTTACCTAACAAAAGAGTCTTACCAGGCTATGGAGGCTGTGAAAGAACTGCGTCAAGAA
GGTTTTGCTTGTTATTTTACCATGGACGCAGGTCCAAATGTGAAGGTCCTATGTTTAGAAAAAGACTTGGCTCAACTAGC
AGAACGACTTGGCAAAAACTACCGTATTATCGTTTCAAAAACAAAGGATTTACCAGATGTCTAA

Upstream 100 bases:

>100_bases
AAGAAGGAGCCGTAAACACGTGGATCCAAATGTTATAACCGTAACATCCTATGCTAACATTGCTATTATCAAATATTGGG
GAAAAGAGAATCAAGCTAAG

Downstream 100 bases:

>100_bases
TTATTGTGTGCAAACAGGTGGGAAACTATACCTCACAGGCGAATATGCTATCTTAATACCAGGACAAAAAGCCTTAATTC
ACTTTATTCCACTGATGATG

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGVLQNDEEHTKISTIIDQFRQPGQAFVKMETQNNMPTAAGLSSS
SSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAKKPISSRE
GMKLCRDTSTTFDEWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQE
GFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV

Sequences:

>Translated_287_residues
MIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGVLQNDEEHTKISTIIDQFRQPGQAFVKMETQNNMPTAAGLSSS
SSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAKKPISSRE
GMKLCRDTSTTFDEWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQE
GFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV
>Mature_287_residues
MIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGVLQNDEEHTKISTIIDQFRQPGQAFVKMETQNNMPTAAGLSSS
SSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAKKPISSRE
GMKLCRDTSTTFDEWVEQSAIDYQHMLTYLKTNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQE
GFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=296, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537201, Length=297, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17537203, Length=179, Percent_Identity=27.9329608938547, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324371, Length=295, Percent_Identity=29.1525423728814, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28571205, Length=296, Percent_Identity=25.3378378378378, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 31722; Mature: 31722

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGVLQNDEEHTKISTIIDQFRQPGQ
CCCCCCCEEEEHHHHHHHCEEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCH
AFVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFF
HEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
GPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDEWVEQSA
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHH
IDYQHMLTYLKTNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQE
HHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV
CCEEEEEECCCCCEEEEEECHHHHHHHHHHCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGVLQNDEEHTKISTIIDQFRQPGQ
CCCCCCCEEEEHHHHHHHCEEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCH
AFVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFF
HEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
GPVAAWDKDSGAIYKVETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDEWVEQSA
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHH
IDYQHMLTYLKTNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQE
HHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GFACYFTMDAGPNVKVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV
CCEEEEEECCCCCEEEEEECHHHHHHHHHHCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA