BacMap

Definition	Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession	NC_004070
Length	1,900,521

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The map label for this gene is butA [H]

Identifier: 21909994

GI number: 21909994

Start: 502036

End: 502800

Strand: Direct

Name: butA [H]

Synonym: SpyM3_0458

Alternate gene names: 21909994

Gene position: 502036-502800 (Clockwise)

Preceding gene: 21909992

Following gene: 21909995

Centisome position: 26.42

GC content: 39.61

Gene sequence:

>765_bases
ATGTCAAAAGTTGCTATTGTTACTGGTGCTGGTCAAGGAATTGGATTTGCTATTGCGAAACGTCTTCATGCAGACGGCTT
TAAAATAGGCATTTTAGACTATAATGAAGAGACTGTTCAGGCTGCGGTTGATAAACTATCACCTGAGGATGCTGTTGCAG
TTGTAGCAGATGTTTCAAAACGTGACCAAGTTTTTGATGCTTTCCAAAAAGTTGTAGATACTTTTGGTGATTTGAATGTT
GTTGTTAACAATGCAGGTGTTGCCCCAACAACCCCTCTTGACACGATTACTGAAGAGCAGTTTGAAAAGGCTTTTGCAAT
CAATGTCGGAGGAACGATTTGGGGAAGCCAAGCAGCTCAAAAACATTTTAGAGAATTAGGTCATGGCGGAAAAATTATAA
ATGCAACGTCACAAGCAGGATGTGAAGGGAATCCTAATTTGACTGTTTACGGTGGTACAAAATTTACAGTTCGTGGTATT
ACACAGACTTTGGCAAAGGATTTGGCATCAGAAGGAATCACAGTCAATGCTTACGCACCAGGTATTGTTAAAACACCTAT
GATGTTTGATATTGCCCATGAAGTTGGTAAAAATGCAGGCAAAGATGATGAATGGGGTATGGAGCAATTTGCAAAAGATA
TCACTTTGAAACGCTTGTCTGAACCAGAAGATGTTGCTAATGCAGTAGGCTTCTTAGCGGGAGATGATTCAAATTATATC
ACTGGACAAACAATAGTTGTCGATGGTGGTATGGTATTCCATTAA

Upstream 100 bases:

>100_bases
AAGTAATCAATAAGCCAAGCCTAAAGCTGAACTTAGTTTAAGAACACTGACTTTTTGAGAGCAACCTAATCGGTTGACTA
AAAAATATGAGGTGGAAGAT

Downstream 100 bases:

>100_bases
AAATGATTAATACTGACACTGTGAGTTTCACTCACAGTGTTTTTTATATTTCTTAAAAAATTATCCTATCTTGATTATTG
GAGTGATGGCACCTTTGAGG

Product: acetoin reductase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETVQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNV
VVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFTVRGI
TQTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMEQFAKDITLKRLSEPEDVANAVGFLAGDDSNYI
TGQTIVVDGGMVFH

Sequences:

>Translated_254_residues
MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETVQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNV
VVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFTVRGI
TQTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMEQFAKDITLKRLSEPEDVANAVGFLAGDDSNYI
TGQTIVVDGGMVFH
>Mature_253_residues
SKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETVQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNVV
VNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFTVRGIT
QTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMEQFAKDITLKRLSEPEDVANAVGFLAGDDSNYIT
GQTIVVDGGMVFH

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=34.2307692307692, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=33.9920948616601, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=33.0677290836653, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI31542939, Length=244, Percent_Identity=35.2459016393443, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=29.7709923664122, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=30.2040816326531, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=31.8725099601594, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=36.1581920903955, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=29.296875, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=29.8245614035088, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=28.1746031746032, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=28.4615384615385, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI142976729, Length=188, Percent_Identity=30.3191489361702, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI210032110, Length=194, Percent_Identity=31.9587628865979, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=32.7956989247312, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=235, Percent_Identity=31.063829787234, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=31.1111111111111, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=26.063829787234, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=27.5, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4504503, Length=218, Percent_Identity=28.8990825688073, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI83715985, Length=260, Percent_Identity=26.5384615384615, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=33.8645418326693, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=31.3953488372093, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=32.9317269076305, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=31.3253012048193, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=30.8, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=28.957528957529, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786812, Length=247, Percent_Identity=31.1740890688259, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=29.9212598425197, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=30.0395256916996, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=30.3149606299213, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=27.734375, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.4046692607004, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787820, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=25.0965250965251, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786701, Length=193, Percent_Identity=27.979274611399, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=35.8267716535433, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=32.5396825396825, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=33.0677290836653, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=32.4, Blast_Score=116, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=32, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=33.5907335907336, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=31.8007662835249, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193204405, Length=259, Percent_Identity=32.046332046332, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=32.5842696629214, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=32.183908045977, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=27.4809160305344, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=28.6821705426357, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.811320754717, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=32.5670498084291, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=30.8880308880309, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=31.3953488372093, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=31.1787072243346, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=30.6201550387597, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=27.3408239700375, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=31.1787072243346, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=32.4528301886792, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=193, Percent_Identity=30.5699481865285, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=26.5625, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=259, Percent_Identity=27.4131274131274, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=30.8270676691729, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=260, Percent_Identity=28.4615384615385, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=25.9842519685039, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=29.8429319371728, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=256, Percent_Identity=26.953125, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=32.9365079365079, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=31.0756972111554, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=32.5396825396825, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=28.6852589641434, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=29.9212598425197, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=29.8387096774194, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644337, Length=232, Percent_Identity=28.448275862069, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640492, Length=190, Percent_Identity=34.7368421052632, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281364892, Length=170, Percent_Identity=33.5294117647059, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=27.9527559055118, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737361, Length=261, Percent_Identity=28.3524904214559, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281364494, Length=242, Percent_Identity=28.9256198347107, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=27.1356783919598, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24665243, Length=261, Percent_Identity=26.0536398467433, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221331218, Length=261, Percent_Identity=26.0536398467433, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24581726, Length=173, Percent_Identity=26.0115606936416, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24665247, Length=262, Percent_Identity=26.3358778625954, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331216, Length=262, Percent_Identity=26.3358778625954, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641232, Length=209, Percent_Identity=27.7511961722488, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574402, Length=190, Percent_Identity=26.8421052631579, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24584744, Length=190, Percent_Identity=26.8421052631579, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28571387, Length=200, Percent_Identity=26, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116007236, Length=201, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510726, Length=194, Percent_Identity=28.8659793814433, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641388, Length=202, Percent_Identity=29.2079207920792, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 26878; Mature: 26747

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETVQAAVDKLSPEDAVAVVADVSK
CCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCHHEEEEHHCHH
RDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQ
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCHHHH
KHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFTVRGITQTLAKDLASEGITVNAYAP
HHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHCCEEEEEECC
GIVKTPMMFDIAHEVGKNAGKDDEWGMEQFAKDITLKRLSEPEDVANAVGFLAGDDSNYI
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCCCEE
TGQTIVVDGGMVFH
ECEEEEEECCEEEC
>Mature Secondary Structure 
SKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETVQAAVDKLSPEDAVAVVADVSK
CCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCHHEEEEHHCHH
RDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQ
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCHHHH
KHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFTVRGITQTLAKDLASEGITVNAYAP
HHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHCCEEEEEECC
GIVKTPMMFDIAHEVGKNAGKDDEWGMEQFAKDITLKRLSEPEDVANAVGFLAGDDSNYI
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCCCEE
TGQTIVVDGGMVFH
ECEEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA