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The map label for this gene is vraB [H]

Identifier: 21909905

GI number: 21909905

Start: 409827

End: 410975

Strand: Direct

Name: vraB [H]

Synonym: SpyM3_0369

Alternate gene names: 21909905

Gene position: 409827-410975 (Clockwise)

Preceding gene: 21909904

Following gene: 21909906

Centisome position: 21.56

GC content: 44.39

Gene sequence:

>1149_bases
ATGACGGATGTTTATATTGCTGCAGGCCTTAGAACCCCTATCGGTTTAGTAGGGAAACAATTTGCTAAAGAGCAGCCAGA
AATCCTTGGAGCAAAGCTCATCAATGCTTTACAAAATAAGTATCCAGCTCCTATTGACCAAGTGATTTGTGGCAATACCG
TCGGAACGGGTGGTAATATTGGGCGCTTGATGACCCTGTATTCTCATTTAGGAGAATCTGTCTCTGCTTTGACGGTTGAT
ATGCAGTGTGCATCAGCTGGTGCAGCTCTTTCCGTGGGTTATGCTAAAATCAAGGCAGGTATGGCAAGCAACCTTTTAGT
GGGAGGGATTGAAAGCAGCTCCTTACAACCTGAATCGGTATATGCTTCAGCTGATTGGCGCCAAGGAGCCTACAAGGTAG
CTCAGTTTTCTCCAGATAGTATCAGCCCTTTTGCGATGATTGAGGGGGCAGAACGAGTGGCAAGAGAGCATGGCTTTACA
AAGGAGTATTTGAATCACTGGACATTGAGAAGTCATCAAAAGGCTAGTTATTGCCAGGAGCAAGCCCTGTTAGCTGATCT
TATTCTAGACCTGCCAGGAGCCAGTGATCAAGGTATTCGACCGCGCTTGTCAAGTAAGGTGTTGTCAAAGGTACCCCCTA
TCTTAGGAGAAGATCACGTGATTAGTGCAGCCAATGCCTGCCTAACCCATGATGCTGCTGCCTTTTTACAGCTAAGTAGT
CAGCCTTCAGCTTTTAAACTGATTGATGTGGTAGAAGTAGCAGGAGACCCACAGCGTAGCCCTTTAATGGTGATTAAGGC
TAGTCAAGTCCTTTTGGAAAAACATGGTCTAGGGATGGCAGATATGACAGCGATTGAATGGAACGAAGCCTTTGCCGTTA
TTGATGGTCTATTTGAAACCCATTATCCAGATTTATTGGACCGCTATAATATATTTGGTGGTGCATTAGCTTATGGTCAT
CCCTATGGTGCCTCAGCAGCCATTATAATATTGCACTTAATGAGGGCTTTAGAGATTAAAAATGGACGCTATGGAATAGC
TGCTATAGCAGCAGCTGGTGGCCAAGGGTTTGCTGTTTTACTAAAATATCATAAGGAGTTTAGTCATGCTGACAAAGCTA
GAATATTGGGCAAAGCAATGCCCAAATAA

Upstream 100 bases:

>100_bases
TAGGTGTATTTTTAGCAGTTATTAGTTCAAAAAAGAAAACCATCAGAAATAATTATATAATAACCATTTAAGGATATCGA
AAATAAAGGAGGTCAATATA

Downstream 100 bases:

>100_bases
AAAAGCTATCGTAGCCGATCAGATAAGCTTGACTCATCAAGAGCTATGGCAAGCGGTTTTAATAAAGGATCAGACAATAA
AAGACAGTGTACCATATATC

Product: putative acetyl coenzyme A acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTDVYIAAGLRTPIGLVGKQFAKEQPEILGAKLINALQNKYPAPIDQVICGNTVGTGGNIGRLMTLYSHLGESVSALTVD
MQCASAGAALSVGYAKIKAGMASNLLVGGIESSSLQPESVYASADWRQGAYKVAQFSPDSISPFAMIEGAERVAREHGFT
KEYLNHWTLRSHQKASYCQEQALLADLILDLPGASDQGIRPRLSSKVLSKVPPILGEDHVISAANACLTHDAAAFLQLSS
QPSAFKLIDVVEVAGDPQRSPLMVIKASQVLLEKHGLGMADMTAIEWNEAFAVIDGLFETHYPDLLDRYNIFGGALAYGH
PYGASAAIIILHLMRALEIKNGRYGIAAIAAAGGQGFAVLLKYHKEFSHADKARILGKAMPK

Sequences:

>Translated_382_residues
MTDVYIAAGLRTPIGLVGKQFAKEQPEILGAKLINALQNKYPAPIDQVICGNTVGTGGNIGRLMTLYSHLGESVSALTVD
MQCASAGAALSVGYAKIKAGMASNLLVGGIESSSLQPESVYASADWRQGAYKVAQFSPDSISPFAMIEGAERVAREHGFT
KEYLNHWTLRSHQKASYCQEQALLADLILDLPGASDQGIRPRLSSKVLSKVPPILGEDHVISAANACLTHDAAAFLQLSS
QPSAFKLIDVVEVAGDPQRSPLMVIKASQVLLEKHGLGMADMTAIEWNEAFAVIDGLFETHYPDLLDRYNIFGGALAYGH
PYGASAAIIILHLMRALEIKNGRYGIAAIAAAGGQGFAVLLKYHKEFSHADKARILGKAMPK
>Mature_381_residues
TDVYIAAGLRTPIGLVGKQFAKEQPEILGAKLINALQNKYPAPIDQVICGNTVGTGGNIGRLMTLYSHLGESVSALTVDM
QCASAGAALSVGYAKIKAGMASNLLVGGIESSSLQPESVYASADWRQGAYKVAQFSPDSISPFAMIEGAERVAREHGFTK
EYLNHWTLRSHQKASYCQEQALLADLILDLPGASDQGIRPRLSSKVLSKVPPILGEDHVISAANACLTHDAAAFLQLSSQ
PSAFKLIDVVEVAGDPQRSPLMVIKASQVLLEKHGLGMADMTAIEWNEAFAVIDGLFETHYPDLLDRYNIFGGALAYGHP
YGASAAIIILHLMRALEIKNGRYGIAAIAAAGGQGFAVLLKYHKEFSHADKARILGKAMPK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=27.0142180094787, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=26.7175572519084, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=27.5510204081633, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=25.2577319587629, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=25.8974358974359, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=30.4455445544554, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=28.75, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=29.3233082706767, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=28.6445012787724, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=25, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=28.4615384615385, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=28.9340101522843, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=26.6355140186916, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25147385, Length=379, Percent_Identity=25.8575197889182, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=27.5434243176179, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=27.4358974358974, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24655093, Length=386, Percent_Identity=27.979274611399, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=27.8688524590164, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=26.2086513994911, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=25.6345177664975, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 40786; Mature: 40655

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVYIAAGLRTPIGLVGKQFAKEQPEILGAKLINALQNKYPAPIDQVICGNTVGTGGNI
CCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCH
GRLMTLYSHLGESVSALTVDMQCASAGAALSVGYAKIKAGMASNLLVGGIESSSLQPESV
HHHHHHHHHHCCCHHEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCE
YASADWRQGAYKVAQFSPDSISPFAMIEGAERVAREHGFTKEYLNHWTLRSHQKASYCQE
EECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
QALLADLILDLPGASDQGIRPRLSSKVLSKVPPILGEDHVISAANACLTHDAAAFLQLSS
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
QPSAFKLIDVVEVAGDPQRSPLMVIKASQVLLEKHGLGMADMTAIEWNEAFAVIDGLFET
CCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHH
HYPDLLDRYNIFGGALAYGHPYGASAAIIILHLMRALEIKNGRYGIAAIAAAGGQGFAVL
CCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHH
LKYHKEFSHADKARILGKAMPK
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDVYIAAGLRTPIGLVGKQFAKEQPEILGAKLINALQNKYPAPIDQVICGNTVGTGGNI
CCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCH
GRLMTLYSHLGESVSALTVDMQCASAGAALSVGYAKIKAGMASNLLVGGIESSSLQPESV
HHHHHHHHHHCCCHHEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCE
YASADWRQGAYKVAQFSPDSISPFAMIEGAERVAREHGFTKEYLNHWTLRSHQKASYCQE
EECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
QALLADLILDLPGASDQGIRPRLSSKVLSKVPPILGEDHVISAANACLTHDAAAFLQLSS
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
QPSAFKLIDVVEVAGDPQRSPLMVIKASQVLLEKHGLGMADMTAIEWNEAFAVIDGLFET
CCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHH
HYPDLLDRYNIFGGALAYGHPYGASAAIIILHLMRALEIKNGRYGIAAIAAAGGQGFAVL
CCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHH
LKYHKEFSHADKARILGKAMPK
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA