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The map label for this gene is purC [H]

Identifier: 21909555

GI number: 21909555

Start: 36044

End: 36748

Strand: Direct

Name: purC [H]

Synonym: SpyM3_0019

Alternate gene names: 21909555

Gene position: 36044-36748 (Clockwise)

Preceding gene: 21909554

Following gene: 21909556

Centisome position: 1.9

GC content: 36.03

Gene sequence:

>705_bases
GTGACTAACCAGCTTATTTATAAAGGAAAAGCGAAAGATATTTATAGTACAAAAGATGAAAATGTGATTAGAACGGTCTA
TAAAGACCAAGCTACTATGTTGAATGGAGCTCGTAAGGAGACTATTGATGGCAAGGGAGCACTAAATAATCAGATTTCAT
CTCTTATTTTTGAGAAATTAAATAAGGCTGGTGTGGCGACACATTATATTGAGCAAATTTCAAAAAACGAACAATTGAAT
AAAAAAGTTGATATTATTCCACTTGAGGTGGTGTTACGGAATGTGACAGCAGGCTCATTTTCAAAACGTTTTGGAGTGGA
AGAAGGACGTGTTCTTGAAACGCCAATTGTGGAATTTTACTACAAAAATGATGATCTGAATGATCCTTTTATCAATGATG
AGCATGTGAAGTTTTTGGGTATTGTTAATGATGAGGAGATTGCTTATCTGAAAGGAGAGACTCGCCGTATTAATGAACTC
TTGAAATGTTGGTTTGCTCAGATTGGGCTTAACTTGATTGACTTTAAGTTGGAGTTCGGATTTGATCAAGAAGGTACAAT
TATCTTAGCAGATGAATTTTCGCCTGATAACTGTCGCCTATGGGATAAGAATGGTAACCATATGGACAAGGATGTTTTTA
GAAGAGACCTTGGCAACCTGACGGATGTCTATCAAGTTGTACTTGAGAAGTTGATAGCATTGTAA

Upstream 100 bases:

>100_bases
CCTTTTTTTAAAAAAAACTTATAAACGTAAATAATATCTTGAATATTTTTATAGAGTATGTTACTCTTAAATGAAAACAG
AAAGAAAGGCGAATAATCAA

Downstream 100 bases:

>100_bases
CTAGAAGAGGAAGGAATTGAATCCGTTCGGGAAACTCCGAAAAAAAGATGGAACTTACTGAAATCTCAATTTCAGATGTC
CTCCTATTTTCCAGTCGCTC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVATHYIEQISKNEQLN
KKVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINEL
LKCWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL

Sequences:

>Translated_234_residues
MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVATHYIEQISKNEQLN
KKVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINEL
LKCWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
>Mature_233_residues
TNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVATHYIEQISKNEQLNK
KVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELL
KCWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=227, Percent_Identity=35.2422907488987, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI5453539, Length=227, Percent_Identity=35.2422907488987, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI119220559, Length=234, Percent_Identity=33.7606837606838, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=42.2907488986784, Blast_Score=189, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=231, Percent_Identity=35.4978354978355, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18860083, Length=228, Percent_Identity=30.7017543859649, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583917, Length=248, Percent_Identity=28.2258064516129, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26873; Mature: 26742

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKL
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHH
NKAGVATHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFY
HHCCHHHHHHHHHHCCHHCCCCCCEEEHHHHHHHCCCCCHHHHCCCCCCCEECCCEEEEE
YKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKCWFAQIGLNLIDFKLEFG
ECCCCCCCCCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEEEEC
FDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
CCCCCEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKL
CCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHH
NKAGVATHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGRVLETPIVEFY
HHCCHHHHHHHHHHCCHHCCCCCCEEEHHHHHHHCCCCCHHHHCCCCCCCEECCCEEEEE
YKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKCWFAQIGLNLIDFKLEFG
ECCCCCCCCCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEEEEC
FDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
CCCCCEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA