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The map label for this gene is pth [H]

Identifier: 21909541

GI number: 21909541

Start: 4665

End: 5234

Strand: Direct

Name: pth [H]

Synonym: SpyM3_0005

Alternate gene names: 21909541

Gene position: 4665-5234 (Clockwise)

Preceding gene: 21909540

Following gene: 21909542

Centisome position: 0.25

GC content: 31.75

Gene sequence:

>570_bases
ATGGTAAAAATGATTGTTGGTCTGGGAAATCCAGGCTCTAAATATGAAAAAACAAAGCACAATATTGGTTTTATGGCTAT
TGACAATATTGTCAAGAACCTTGACGTTACCTTTACAGATGATAAAAATTTTAAAGCACAGATAGGAAGTACTTTTATTA
ATCATGAAAAAGTTTGCTTTGTGAAACCTACTACTTTTATGAATAATAGCGGCATAGCAGTAAAAGCATTACTAACCTAC
TATAATATTGACATAACAGATTTAATTGTTATCTATGATGATTTAGACATGGAAGTCAGTAAATTACGTTTACGTAGTAA
GGGTTCAGCAGGAGGACATAATGGCATTAAGTCAATCATTGCCCACATTGGAACTCAGGAATTTAACCGAATCAAAGTTG
GTATTGGACGACCTTTAAAAGGTATGACTGTTATTAACCATGTGATGGGCCAATTCAATACTGAAGATAATATTGCTATT
TCGTTAACTCTTGACAGAGTTGTCAATGCTGTCAAGTTTTATTTACAAGAAAATGATTTTGAAAAAACAATGCAGAAATT
TAATGGATAA

Upstream 100 bases:

>100_bases
GGACATCATGGAATTCAGATTTAATGTGTAATTATATTAAAACAATATCAGAAGGTTGGAAGAACATTCCAGCCCTTTTG
GCATTTTAGAAAGAGAAAAT

Downstream 100 bases:

>100_bases
TCATGGATATTTTAGAATTATTTAGTCAGAATAAGAAAGTCCAATCCTGGCACTCTGGATTAACCACCTTAGGAAGACAA
CTGGTAATGGGGTTATCGGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MVKMIVGLGNPGSKYEKTKHNIGFMAIDNIVKNLDVTFTDDKNFKAQIGSTFINHEKVCFVKPTTFMNNSGIAVKALLTY
YNIDITDLIVIYDDLDMEVSKLRLRSKGSAGGHNGIKSIIAHIGTQEFNRIKVGIGRPLKGMTVINHVMGQFNTEDNIAI
SLTLDRVVNAVKFYLQENDFEKTMQKFNG

Sequences:

>Translated_189_residues
MVKMIVGLGNPGSKYEKTKHNIGFMAIDNIVKNLDVTFTDDKNFKAQIGSTFINHEKVCFVKPTTFMNNSGIAVKALLTY
YNIDITDLIVIYDDLDMEVSKLRLRSKGSAGGHNGIKSIIAHIGTQEFNRIKVGIGRPLKGMTVINHVMGQFNTEDNIAI
SLTLDRVVNAVKFYLQENDFEKTMQKFNG
>Mature_189_residues
MVKMIVGLGNPGSKYEKTKHNIGFMAIDNIVKNLDVTFTDDKNFKAQIGSTFINHEKVCFVKPTTFMNNSGIAVKALLTY
YNIDITDLIVIYDDLDMEVSKLRLRSKGSAGGHNGIKSIIAHIGTQEFNRIKVGIGRPLKGMTVINHVMGQFNTEDNIAI
SLTLDRVVNAVKFYLQENDFEKTMQKFNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=28.6516853932584, Blast_Score=110, Evalue=7e-25,
Organism=Escherichia coli, GI1787455, Length=177, Percent_Identity=31.0734463276836, Blast_Score=96, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21137; Mature: 21137

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMIVGLGNPGSKYEKTKHNIGFMAIDNIVKNLDVTFTDDKNFKAQIGSTFINHEKVCF
CEEEEEEECCCCCHHHHHHHCCCCEEHHHHHHHCCEEEECCCCCHHHHCCHHCCCCEEEE
VKPTTFMNNSGIAVKALLTYYNIDITDLIVIYDDLDMEVSKLRLRSKGSAGGHNGIKSII
ECCCEEECCCCCEEEEEEHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHH
AHIGTQEFNRIKVGIGRPLKGMTVINHVMGQFNTEDNIAISLTLDRVVNAVKFYLQENDF
HHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCCCH
EKTMQKFNG
HHHHHHHCC
>Mature Secondary Structure
MVKMIVGLGNPGSKYEKTKHNIGFMAIDNIVKNLDVTFTDDKNFKAQIGSTFINHEKVCF
CEEEEEEECCCCCHHHHHHHCCCCEEHHHHHHHCCEEEECCCCCHHHHCCHHCCCCEEEE
VKPTTFMNNSGIAVKALLTYYNIDITDLIVIYDDLDMEVSKLRLRSKGSAGGHNGIKSII
ECCCEEECCCCCEEEEEEHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHH
AHIGTQEFNRIKVGIGRPLKGMTVINHVMGQFNTEDNIAISLTLDRVVNAVKFYLQENDF
HHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCCCH
EKTMQKFNG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]