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The map label for this gene is atpB

Identifier: 218931103

GI number: 218931103

Start: 4649048

End: 4649872

Strand: Reverse

Name: atpB

Synonym: YPO4127

Alternate gene names: 218931103

Gene position: 4649872-4649048 (Counterclockwise)

Preceding gene: 218931104

Following gene: 218931102

Centisome position: 99.92

GC content: 46.06

Gene sequence:

>825_bases
ATGTCTGCATCAGGAGAAATCTCTACTCCAAGGGACTACATAGGTCACCACCTGAATCACCTTCAGTTGGACCTGCGTAC
CTTTGAGTTGGTCAATCCCCACTCAACTGGCCCTGCAACGTTCTGGACGTTGAACATTGACTCTTTGTTCTTCTCTGTCG
TGCTGGGGTTAGCTTTTCTGCTTGTGTTCCGCAAAGTTGCTGCAAGCGCCACCAGTGGCGTACCCGGTAAATTGCAGACT
GCTGTAGAGTTAATTATCGGTTTTGTCGATAACAGTGTGCGGGATATGTATCACGGCAAAAGTAAAGTCATCGCACCATT
AGCCCTAACAGTCTTTGTTTGGGTTTTATTGATGAACATGATGGATTTACTGCCAATCGATTTACTGCCTTACATCGGTG
AACATGTCTTTGGGTTACCAGCACTGCGTGTGGTACCTACAGCTGACGTGAGCATTACGTTGTCTATGGCATTGGGTGTT
TTCATCCTGATTATTTTCTATAGCATTAAAATGAAAGGTGTAGGCGGCTTCACAAAAGAATTAACTATGCAGCCGTTCAA
TCACCCGATATTCATTCCAGTAAACTTAATTCTGGAAGGTGTCAGCCTGCTGTCCAAACCGCTTTCATTGGGTCTGCGAC
TGTTCGGCAACATGTATGCGGGTGAGTTGATCTTCATCCTGATTGCGGGTCTGTTGCCGTGGTGGTCACAGTGGATGCTC
AGTGTTCCTTGGGCTATATTCCACATCCTGATCATTACGTTACAAGCCTTTATCTTCATGGTTCTGACGATTGTCTATCT
CTCGATGGCATCCGAAGAGCACTGA

Upstream 100 bases:

>100_bases
TTTATCGGTGCTGATTGTGCAGATTTTAGCACCGGCCGTGATTAACGGTCACCGTACTTAACAGTTATCGTATTTAACTA
CAACAAGGGTAAGAGGCATC

Downstream 100 bases:

>100_bases
TTTTCTTATAACACTACTGCGTTTTAACTGAAATAAACTGGAGACTGTCATGGAAAACCTGAATATGGATCTGCTGTACA
TGGCTGCCGCTGTGATGATG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQT
AVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGV
FILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Sequences:

>Translated_274_residues
MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQT
AVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGV
FILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
>Mature_273_residues
SASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFLLVFRKVAASATSGVPGKLQTA
VELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNMMDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVF
ILIIFYSIKMKGVGGFTKELTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWMLS
VPWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=271, Percent_Identity=84.1328413284133, Blast_Score=446, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_YERP3 (A7FPE6)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001403124.1
- ProteinModelPortal:   A7FPE6
- STRING:   A7FPE6
- GeneID:   5388386
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_4182
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   LPWWSQF
- ProtClustDB:   PRK05815
- BioCyc:   YPSE349747:YPSIP31758_4182-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 30412; Mature: 30281

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x187aa4f8)-; HASH(0x19670004)-; HASH(0x196d1c6c)-; HASH(0x196d9e74)-; HASH(0x194e9878)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHH
LVFRKVAASATSGVPGKLQTAVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVFILIIFYSIKMKGVGGFTKE
HHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SASGEISTPRDYIGHHLNHLQLDLRTFELVNPHSTGPATFWTLNIDSLFFSVVLGLAFL
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHH
LVFRKVAASATSGVPGKLQTAVELIIGFVDNSVRDMYHGKSKVIAPLALTVFVWVLLMNM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MDLLPIDLLPYIGEHVFGLPALRVVPTADVSITLSMALGVFILIIFYSIKMKGVGGFTKE
HHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LTMQPFNHPIFIPVNLILEGVSLLSKPLSLGLRLFGNMYAGELIFILIAGLLPWWSQWML
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA