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The map label for this gene is mtlD [H]

Identifier: 218931049

GI number: 218931049

Start: 4586148

End: 4587311

Strand: Reverse

Name: mtlD [H]

Synonym: YPO4067

Alternate gene names: 218931049

Gene position: 4587311-4586148 (Counterclockwise)

Preceding gene: 218931050

Following gene: 218931048

Centisome position: 98.57

GC content: 51.2

Gene sequence:

>1164_bases
ATGAAAGCATTACATTTTGGCGCAGGGAATATTGGCCGTGGCTTCATCGGCAAACTGCTCGCGGATGCCGGTGCGCAACT
GACCTTCGCCGATGTGAATCAACCGTTGTTGGATGAACTGAATAAACGTAAACGTTATCAGGTCAATGTGGTCGGTGAAC
AGGCTCGGGTTGAAGAGGTAAAGAATGTCAGTGCGGTAAACAGCGGTAGCCCGGAAGTGGTTGCGCTGATTGCTGAGGCC
GATATTGTCACCACCGCTGTTGGCCCACAAATTTTGGCCAGAATTGCGGCGACAGTGGCACAGGGTCTGATCACTCGACA
TCAGCAAGGGAATACCCGCCCACTGAATATTATTGCCTGCGAAAATATGGTGCGTGGCACTAGCCAATTAAAACAACATG
TGTTTGCTGCCTTATCAGAAGACGAACAAATATGGGTAGAGCAGCATGTGGGTTTTGTGGATTCGGCAGTCGATCGTATT
GTCCCACCATCAGAAGCGGGCAGTACTGATATCCTGGCTGTCACGGTAGAAACCTTTAGCGAATGGATAGTCGACGGTAC
CCAATTTAAAGGCCAGCCACCCGAAATCGTGGGTATGGAATTGACCGATAATCTCATGGCTTTTGTCGAGCGTAAGCTCT
TCACGTTGAACACCGGGCATGCTATTACCGCGTATCTGGGCCAACTGGCAGGCCATCAAACGATCCGCGATGCGATTCTC
GACCCGGCGGTACGTCAAACAGTAAAAGGTGCGATGGAAGAGAGCGGTGCGGTACTGATTAAGCGTTATGCTTTCGACCC
ACAGAAACATGCGGCTTATATCAACAAAATTCTCTCTCGTTTTGAAAACCCTTATTTGCACGATGATGTCGAGCGGGTTG
GCCGTCAACCACTGCGTAAGCTGAGCGCCGGTGATCGTTTGATCAAACCGCTGCTAGGCACGCTGGAGTATCAATTGCCG
CACGATTCTCTGGTAACGGGTATTGCCGCCGCCATGAGCTATCGCAGTGAGCAAGATCCACAGGCCCAAGAGTTGGTGAC
GTTATTGGCACAATTAGGGCCGAAAGCTGCGTTAGCGCAAATTTCAGGCTTGCCTGCTGATAGTGAGGTTGTCGAACAGG
CGGTGAGTGTGTATAACGCCATGCAGCAGAAGCTGGCGCACTGA

Upstream 100 bases:

>100_bases
TGCTTTGCCTACCTGCAACGCGAATTATTTAGCGTATAAACAAGTCATAACTGCTAGGGCTGTTGGAAGAAAATGGCCCT
TTTACAGCAAGGTAACGAAT

Downstream 100 bases:

>100_bases
TTTTAGTGACTAAGCCAGCTATGTCCCATTGGCCTGATAACGGAAACGATAGCGGGCCAATGATTTAAGACACTAAAGTA
TTTGCCAACGGATGATTTGT

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEA
DIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRI
VPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAIL
DPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLP
HDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPADSEVVEQAVSVYNAMQQKLAH

Sequences:

>Translated_387_residues
MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEA
DIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRI
VPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAIL
DPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLP
HDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPADSEVVEQAVSVYNAMQQKLAH
>Mature_387_residues
MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEVKNVSAVNSGSPEVVALIAEA
DIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIACENMVRGTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRI
VPPSEAGSTDILAVTVETFSEWIVDGTQFKGQPPEIVGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAIL
DPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYLHDDVERVGRQPLRKLSAGDRLIKPLLGTLEYQLP
HDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQISGLPADSEVVEQAVSVYNAMQQKLAH

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=75.6544502617801, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1787823, Length=260, Percent_Identity=27.6923076923077, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788497, Length=259, Percent_Identity=27.7992277992278, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790779, Length=262, Percent_Identity=27.4809160305344, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324401, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320765, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 42019; Mature: 42019

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEV
CCCEECCCCCCCHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHCCCEEEEEECCHHHHHHH
KNVSAVNSGSPEVVALIAEADIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIAC
HHHHHCCCCCCCEEEEEECCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
ENMVRGTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEEEHHHHH
EWIVDGTQFKGQPPEIVGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAIL
HHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
DPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYLHDDVERVGRQPLRK
CHHHHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYQLPHDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
ISGLPADSEVVEQAVSVYNAMQQKLAH
HCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGAQLTFADVNQPLLDELNKRKRYQVNVVGEQARVEEV
CCCEECCCCCCCHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHCCCEEEEEECCHHHHHHH
KNVSAVNSGSPEVVALIAEADIVTTAVGPQILARIAATVAQGLITRHQQGNTRPLNIIAC
HHHHHCCCCCCCEEEEEECCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
ENMVRGTSQLKQHVFAALSEDEQIWVEQHVGFVDSAVDRIVPPSEAGSTDILAVTVETFS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEEEHHHHH
EWIVDGTQFKGQPPEIVGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHQTIRDAIL
HHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
DPAVRQTVKGAMEESGAVLIKRYAFDPQKHAAYINKILSRFENPYLHDDVERVGRQPLRK
CHHHHHHHHHHHHCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYQLPHDSLVTGIAAAMSYRSEQDPQAQELVTLLAQLGPKAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
ISGLPADSEVVEQAVSVYNAMQQKLAH
HCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA