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The map label for this gene is hutH

Identifier: 218931007

GI number: 218931007

Start: 4529468

End: 4531000

Strand: Reverse

Name: hutH

Synonym: YPO4016

Alternate gene names: 218931007

Gene position: 4531000-4529468 (Counterclockwise)

Preceding gene: 218931008

Following gene: 218931006

Centisome position: 97.36

GC content: 50.75

Gene sequence:

>1533_bases
ATGAAGACAATAACACTACGTCCTGGTCAGATGACGCTGGCTGACTTACGGCATATTTATCAACATCCCGTACATATCAC
ATTGGATGAAAGTGCCTATGTACCCATTCAGCAAAGTGTGGATTGTGTGCAAGCCATATTGGCAGAACAGCGCACGGCAT
ATGGCATTAACACTGGGTTTGGCTTGCTGGCCTCTACCCGTATCGCCACCGAAGACTTGGAAAACTTACAGCGCTCAATC
GTACTCTCTCACGCGGCAGGAGTCGGAGAAGCGAATGATGATGCGATTGTGCGTCTGATTATGGTGCTGAAAATCAATAG
CCTGGCGAGAGGTTTCTCAGGTATTCGGCTGGAGGTGATTCAGGCGCTGATTACCTTGGTCAATGCTGGGGTTTATCCGC
ATATCCCGTTAAAAGGATCAGTGGGCGCTTCTGGCGATTTAGCTCCGCTGGCACATATGAGCTTGCTGCTATTAGGTGAA
GGAAAAGCCCGCTATCAGGGTGAATGGTTGCCCGCACACACGGCACTGGCGCAAGCGGGTTTGCAGCCCCTCACACTGGC
GGCGAAAGAGGGTTTGGCACTACTTAACGGCACCCAGGTCTCTGCCGCTTATGCATTGCGTGGTTTATTTGAGGCCGAAG
ATCTCTATGCGGCCGCTTCGGTGTTTGGCTGCCTGACAGTGGATGCAGCATTAGGATCCCGTAGCCCATTTGACGCCCGT
ATTCACGCCGTTCGGGGCCAACGTGGGCAGATTGATGCTGCCAGCACTTATCGTCATCTGCTTGGTGAACGCAGTGAAAT
CTCAGAATCACACAAGAATTGTGACAAAGTGCAGGATCCATATTCTTTACGCTGTCAGCCACAGGTGATGGGCGCATGTT
TAGGCCAAATACGTCAGGCGGCAGAGGTGCTGGCTATTGAATCCAATGCCGTTTCAGATAACCCGTTGGTGTTTGCTGAA
CAGGGTGATGTCTTGTCTGGTGGGAATTTCCATGCTGAACCGGTCGCTATGGCAGCAGATAATCTGGCGTTGGCGTTGGC
AGAAGTCGGTTCATTATCAGAGTGCCGTATCTCGTTGATGATGGACAAGCATATGTCTCAGTTACCTCCATTTCTGGTAG
AGAACGGTGGCGTAAATTCTGGTTTTATGATTGCTCAGGTTACGGCTGCGGCGTTAACCAGTGAAAATAAAGGGCTGGCA
TTCCCCGCCAGTGTCGATAGCATCCCAACATCTGCTAATCAGGAAGATCATGTCTCTATGGCCCCTCGGGCGGGTAAACG
CTTGTGGGAAATGGCTGAAAATGTACGGAATATACTGGCTATCGAGTGGCTGGCTGCGTGTCAGGGGCTTGATTTGCGCA
AAGGGCTAAGAACTTCCGCCATACTGGAGCCCGCCCGCCAACTATTACGCCAGCACGTCACTTACTACGATAAAGATCGT
TTCTTTGCCCCCGATATTGAAGTTGCTAGCCAGCTTATTGCACAACGTCATATGAATGAGTTGATGCCAGCAAAATTACT
GCCAAGTCTTTAA

Upstream 100 bases:

>100_bases
TGATGCGCCATGCAGATGCGGGTTATGACATTGCGGTTAACTGCGCGCAAGAGCAAGGACTTAACCTACCAATGGTTGCC
GCAACTCAGGGGAAAAAATC

Downstream 100 bases:

>100_bases
TAACAATAGTTTTCCAAGACAGTCATTTCCCAAGGCAGCAGTTTCCAAATACAGCAGTTTCCCAAGACAATAGGTTTCCA
AGACAGTCGTTTCCAAAGAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGFGLLASTRIATEDLENLQRSI
VLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVIQALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGE
GKARYQGEWLPAHTALAQAGLQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQAAEVLAIESNAVSDNPLVFAE
QGDVLSGGNFHAEPVAMAADNLALALAEVGSLSECRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLA
FPASVDSIPTSANQEDHVSMAPRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
FFAPDIEVASQLIAQRHMNELMPAKLLPSL

Sequences:

>Translated_510_residues
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGFGLLASTRIATEDLENLQRSI
VLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVIQALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGE
GKARYQGEWLPAHTALAQAGLQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQAAEVLAIESNAVSDNPLVFAE
QGDVLSGGNFHAEPVAMAADNLALALAEVGSLSECRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLA
FPASVDSIPTSANQEDHVSMAPRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
FFAPDIEVASQLIAQRHMNELMPAKLLPSL
>Mature_510_residues
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGFGLLASTRIATEDLENLQRSI
VLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVIQALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGE
GKARYQGEWLPAHTALAQAGLQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQAAEVLAIESNAVSDNPLVFAE
QGDVLSGGNFHAEPVAMAADNLALALAEVGSLSECRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLA
FPASVDSIPTSANQEDHVSMAPRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
FFAPDIEVASQLIAQRHMNELMPAKLLPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=504, Percent_Identity=43.8492063492063, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=469, Percent_Identity=42.8571428571429, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_YERPE (Q8ZA10)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AG0488
- RefSeq:   NP_671330.1
- RefSeq:   NP_994665.1
- RefSeq:   YP_002348882.1
- ProteinModelPortal:   Q8ZA10
- SMR:   Q8ZA10
- IntAct:   Q8ZA10
- GeneID:   1148984
- GeneID:   1176853
- GeneID:   2767303
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO4016
- KEGG:   ypk:y4037
- KEGG:   ypm:YP_3379
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   YPES187410:Y4037-MONOMER
- BioCyc:   YPES214092:YPO4016-MONOMER
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54828; Mature: 54828

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00488 PAL_HISTIDASE; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGF
CCEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
GLLASTRIATEDLENLQRSIVLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
QALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGEGKARYQGEWLPAHTALAQAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHCC
LQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
CCCEEHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQA
HHEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLAIESNAVSDNPLVFAEQGDVLSGGNFHAEPVAMAADNLALALAEVGSLSECRISLM
HHHHEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
MDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLAFPASVDSIPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCC
APRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCEECCCC
FFAPDIEVASQLIAQRHMNELMPAKLLPSL
CCCCCHHHHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MKTITLRPGQMTLADLRHIYQHPVHITLDESAYVPIQQSVDCVQAILAEQRTAYGINTGF
CCEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
GLLASTRIATEDLENLQRSIVLSHAAGVGEANDDAIVRLIMVLKINSLARGFSGIRLEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
QALITLVNAGVYPHIPLKGSVGASGDLAPLAHMSLLLLGEGKARYQGEWLPAHTALAQAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHCC
LQPLTLAAKEGLALLNGTQVSAAYALRGLFEAEDLYAAASVFGCLTVDAALGSRSPFDAR
CCCEEHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IHAVRGQRGQIDAASTYRHLLGERSEISESHKNCDKVQDPYSLRCQPQVMGACLGQIRQA
HHEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLAIESNAVSDNPLVFAEQGDVLSGGNFHAEPVAMAADNLALALAEVGSLSECRISLM
HHHHEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
MDKHMSQLPPFLVENGGVNSGFMIAQVTAAALTSENKGLAFPASVDSIPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCC
APRAGKRLWEMAENVRNILAIEWLAACQGLDLRKGLRTSAILEPARQLLRQHVTYYDKDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCEECCCC
FFAPDIEVASQLIAQRHMNELMPAKLLPSL
CCCCCHHHHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430