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The map label for this gene is panB [H]

Identifier: 218930418

GI number: 218930418

Start: 3799198

End: 3799998

Strand: Direct

Name: panB [H]

Synonym: YPO3401

Alternate gene names: 218930418

Gene position: 3799198-3799998 (Clockwise)

Preceding gene: 218930417

Following gene: 218930419

Centisome position: 81.64

GC content: 52.18

Gene sequence:

>801_bases
GTGATGAAAACCACCACCATGAGCCAATTACGCCAATGGAAACAAGAGAAACGTAAATTCGCAACGCTGACGGCCTATGA
TGCCAGTTTTGCCCAGTTATTTGCCGAACAGGGTATTCAGGTGCTATTGGTGGGGGATTCGCTCGGTATGACGTTACAAG
GGTTCGATTCCACGCTGCCAGTGACCGTTGCCGATATGGCCTACCATACCCGTGCAGTGCGCCGTGGTGCGCCTCATTGC
CTGTTATTGGCCGATATGCCATTCATGAGTTATGCCACGCCAGAACTGGCCTTTACCCACGCGGCAGAGCTAATGCGGGC
CGGAGCCAATATGGTCAAACTGGAAGGTGGGAGCTGGCTGTGCGATACCATTCGCATGTTGGCAGAGCGCGCGGTGCCGG
TTTGTGGGCATCTGGGGCTCACGCCACAATCGGTGAATATTTTCGGCGGCTATAAAGTACAGGGTCGTGAAGAAGTGGCG
GCCAATCAACTGTTGCAAGATGCTATTGCCCTGGAACAGGCAGGGGCTCAACTGTTGGTACTGGAATGCGTGCCGGTAGA
ACTGGCACAGCGGGTGACCGAAGAGTTAACCATACCGGTTATTGGTATTGGTGCGGGGAATGTCACTGACGGTCAGATTT
TGGTTATGCATGATGCACTCGGTATTACCGGGGGTCATACGCCAAAATTCAGTAAAAACTTTTTAGCACACAGTGCGGGC
GATATTCGTGCCGCCATTAAGCTCTATATTGAAGAAGTTGAGGGGGGGATTTATCCTGCTGAAGAGCATACATTCCAGTA
A

Upstream 100 bases:

>100_bases
AGAATGTCTTGCAGATAATCTTATATTCCATCCCGTAATGGGCAGGTCTTGGTTTATCCGTTTGTTGATAAAGTTGTTCA
CTTTAATTTCAGGAGACAGA

Downstream 100 bases:

>100_bases
CTGAGCCACTAATATTTCTTCTAAAATAGGGAGTTTTCAAAATAGGATCCTCCTAAAATAGATCGTTCCTAAAACAGGAG
AAAGGGAATGCTGATTATTG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MMKTTTMSQLRQWKQEKRKFATLTAYDASFAQLFAEQGIQVLLVGDSLGMTLQGFDSTLPVTVADMAYHTRAVRRGAPHC
LLLADMPFMSYATPELAFTHAAELMRAGANMVKLEGGSWLCDTIRMLAERAVPVCGHLGLTPQSVNIFGGYKVQGREEVA
ANQLLQDAIALEQAGAQLLVLECVPVELAQRVTEELTIPVIGIGAGNVTDGQILVMHDALGITGGHTPKFSKNFLAHSAG
DIRAAIKLYIEEVEGGIYPAEEHTFQ

Sequences:

>Translated_266_residues
MMKTTTMSQLRQWKQEKRKFATLTAYDASFAQLFAEQGIQVLLVGDSLGMTLQGFDSTLPVTVADMAYHTRAVRRGAPHC
LLLADMPFMSYATPELAFTHAAELMRAGANMVKLEGGSWLCDTIRMLAERAVPVCGHLGLTPQSVNIFGGYKVQGREEVA
ANQLLQDAIALEQAGAQLLVLECVPVELAQRVTEELTIPVIGIGAGNVTDGQILVMHDALGITGGHTPKFSKNFLAHSAG
DIRAAIKLYIEEVEGGIYPAEEHTFQ
>Mature_266_residues
MMKTTTMSQLRQWKQEKRKFATLTAYDASFAQLFAEQGIQVLLVGDSLGMTLQGFDSTLPVTVADMAYHTRAVRRGAPHC
LLLADMPFMSYATPELAFTHAAELMRAGANMVKLEGGSWLCDTIRMLAERAVPVCGHLGLTPQSVNIFGGYKVQGREEVA
ANQLLQDAIALEQAGAQLLVLECVPVELAQRVTEELTIPVIGIGAGNVTDGQILVMHDALGITGGHTPKFSKNFLAHSAG
DIRAAIKLYIEEVEGGIYPAEEHTFQ

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=265, Percent_Identity=76.2264150943396, Blast_Score=429, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319653, Length=277, Percent_Identity=36.8231046931408, Blast_Score=168, Evalue=7e-43,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28831; Mature: 28831

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTTTMSQLRQWKQEKRKFATLTAYDASFAQLFAEQGIQVLLVGDSLGMTLQGFDSTLP
CCCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCC
VTVADMAYHTRAVRRGAPHCLLLADMPFMSYATPELAFTHAAELMRAGANMVKLEGGSWL
EEHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCH
CDTIRMLAERAVPVCGHLGLTPQSVNIFGGYKVQGREEVAANQLLQDAIALEQAGAQLLV
HHHHHHHHHHCCCHHCCCCCCCCCEEEEECEEECCHHHHHHHHHHHHHHHHHHCCCEEEE
LECVPVELAQRVTEELTIPVIGIGAGNVTDGQILVMHDALGITGGHTPKFSKNFLAHSAG
EEECCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCCCC
DIRAAIKLYIEEVEGGIYPAEEHTFQ
HHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MMKTTTMSQLRQWKQEKRKFATLTAYDASFAQLFAEQGIQVLLVGDSLGMTLQGFDSTLP
CCCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCC
VTVADMAYHTRAVRRGAPHCLLLADMPFMSYATPELAFTHAAELMRAGANMVKLEGGSWL
EEHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCH
CDTIRMLAERAVPVCGHLGLTPQSVNIFGGYKVQGREEVAANQLLQDAIALEQAGAQLLV
HHHHHHHHHHCCCHHCCCCCCCCCEEEEECEEECCHHHHHHHHHHHHHHHHHHCCCEEEE
LECVPVELAQRVTEELTIPVIGIGAGNVTDGQILVMHDALGITGGHTPKFSKNFLAHSAG
EEECCHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCCCC
DIRAAIKLYIEEVEGGIYPAEEHTFQ
HHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA