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The map label for this gene is cysJ [H]

Identifier: 218930389

GI number: 218930389

Start: 3759881

End: 3761701

Strand: Reverse

Name: cysJ [H]

Synonym: YPO3372

Alternate gene names: 218930389

Gene position: 3761701-3759881 (Counterclockwise)

Preceding gene: 218930391

Following gene: 218930388

Centisome position: 80.83

GC content: 52.39

Gene sequence:

>1821_bases
ATGACGACTCAGGCTCCTCCAACTTCGTTACTTCCGCTATCGCCAGAGCAGTTGGCCCGCTTGCAAGCGGCGGTGGGTGA
ATTCTCCCCAACCCAAATGGCATGGTTGTCGGGTTACTTCTGGGGGATGGTTAACCAGCAGCCCGGCGCTGTTGCTTCCC
CTGCGGTAGCGGCACCCCCACCAGTGACAGTTACCCTGATTTCCGCGTCTCAAACCGGCAACGCCCGGCGTTTAGCTGAA
CAACTGCGCGATGATCTTCTGGCTGCCCAACTTAGTGTCAATCTGGTCAATGCGGGTGATTATAAGTTTAAACAAATTGC
GCAGGAGCGTTTACTGGTGGTGGTCGCATCGACCCAAGGAGAGGGGGAGCCAGCAGAAGAAGCCGTCGCACTGCATAAAT
TCCTGTTTTCTAAAAAAGCCCCAAAATTATCGGAGACCGCATTTGCTGTCTTTGGCTTAGGTGACACCTCTTACGAACAC
TTCTGTCAGGCTGGGAAAGATTTTGATAGCAAGCTGGCAGAACTTGGTGCTCAACGGTTACTGGATCGTGTCGATGCCGA
TGTTGAATATCAGGTACAAGCACAGCAGTGGCGTCAGCAAGTGGTTGCCACGTTGCAGGCTAAGGTTCCAGCACAATCTA
CAGCTCCAACACAATCTACAACTCCAGCAGCAGCGGCGATAACGTCTGGTGGTACCACTACCGTTAGTCCGTACAGTAAA
ACCGCGCCGTTGACCGCACAGTTATCCGTACAGCAAAAAGTGACTGGGCGTAATTCAGAAAAAGATGTTCGTCATATTGA
AATCGATTTAGGTGATTCAGGACTGCGTTACCAACCAGGCGATGCTTTGGGTGTCTGGTTTGATAATGATCCTGCTTTGG
TCGAAGAACTGCTCGCGCTGTTGTGGCTCAAAGGTGATGAGCCGGTCAGTATTGACGGACAAAATATGCCACTGGCACAG
GCGCTGCTCAGTCACCTTGAACTGACACAAAATACGACGCTGATCGTCGATAAATACGCCGCGCTATCACGCGATGAAAC
CTTGATTGCACTGCTGGCAGATAAACCCGCGTTGCAACTGTACGCTAAGAATACGCCATTCGTTGATATGGTGCGGCAGG
CACCGTCTGATCTTAATGCCGATCAACTGGTGGGGTTATTGCGCCCCTTAACGCCACGGTTGTACTCCATCGCCTCTTCG
CAAGCTGAGACCGAAAATGAGGTGCATATCACCGTGGGTGTGGTGCGCTATGACATTGATGGCCGAGCGCGCAGTGGCGG
TGCTTCCGGCTATCTGGCGGACCGGCTGGAAGTCGATGGCGATATCCGTGTCTTTATTGAACACAATGATAATTTCCGTT
TGCCTGCTAACCCGGAAACACCCGTCATCATGATCGGGCCAGGCACCGGTATCGCGCCGTTCCGCGCCTTTATGCAACAG
CGTGAAGTTGATGGGGCCAGTGGCAAGAACTGGTTATTCTTCGGTAATCCTCATTTCACCGAGGATTTTCTGTATCAGGT
TGAATGGCAACGCTATGTCAAAGAAGGCGTGTTGACGCGCATTGATCTGGCCTGGTCCCGTGATCAGGCGCATAAAATAT
ACGTACAAGACAAACTGCGCGAACAGGGCGCGGAACTGTGGAACTGGATACAACAAGGTGCCCACATTTACGTCTGTGGC
GATGCTAACCGCATGGCGAAAGACGTTGAGCAGGTTTTACTGGACGTGGTGGCTCTGCACGGTGCAATGGATGCCGAGCA
GGCTGATGAATATTTAAGTGAGTTGCGCCAAGCGCGCCGCTATCAGCGAGATGTGTACTGA

Upstream 100 bases:

>100_bases
ACCTTACAAACTATCAAGACTTTGTGGCACGAATTGTCCTGCCTATATTGACAAATATTTGTGCCAACCACGGCTAAAGC
ATAAGGGAATTCGTACTGCA

Downstream 100 bases:

>100_bases
TGAATGAAAAACACCCAGGGCCACTCGTCGTCAGTGGAAAACTTTCTGATGGCGAGCGCATGAAGTCGGAAAGCAATTTC
TTGCGTGGGACTATTGCGGA

Product: sulfite reductase subunit alpha

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MTTQAPPTSLLPLSPEQLARLQAAVGEFSPTQMAWLSGYFWGMVNQQPGAVASPAVAAPPPVTVTLISASQTGNARRLAE
QLRDDLLAAQLSVNLVNAGDYKFKQIAQERLLVVVASTQGEGEPAEEAVALHKFLFSKKAPKLSETAFAVFGLGDTSYEH
FCQAGKDFDSKLAELGAQRLLDRVDADVEYQVQAQQWRQQVVATLQAKVPAQSTAPTQSTTPAAAAITSGGTTTVSPYSK
TAPLTAQLSVQQKVTGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWFDNDPALVEELLALLWLKGDEPVSIDGQNMPLAQ
ALLSHLELTQNTTLIVDKYAALSRDETLIALLADKPALQLYAKNTPFVDMVRQAPSDLNADQLVGLLRPLTPRLYSIASS
QAETENEVHITVGVVRYDIDGRARSGGASGYLADRLEVDGDIRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQ
REVDGASGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQAHKIYVQDKLREQGAELWNWIQQGAHIYVCG
DANRMAKDVEQVLLDVVALHGAMDAEQADEYLSELRQARRYQRDVY

Sequences:

>Translated_606_residues
MTTQAPPTSLLPLSPEQLARLQAAVGEFSPTQMAWLSGYFWGMVNQQPGAVASPAVAAPPPVTVTLISASQTGNARRLAE
QLRDDLLAAQLSVNLVNAGDYKFKQIAQERLLVVVASTQGEGEPAEEAVALHKFLFSKKAPKLSETAFAVFGLGDTSYEH
FCQAGKDFDSKLAELGAQRLLDRVDADVEYQVQAQQWRQQVVATLQAKVPAQSTAPTQSTTPAAAAITSGGTTTVSPYSK
TAPLTAQLSVQQKVTGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWFDNDPALVEELLALLWLKGDEPVSIDGQNMPLAQ
ALLSHLELTQNTTLIVDKYAALSRDETLIALLADKPALQLYAKNTPFVDMVRQAPSDLNADQLVGLLRPLTPRLYSIASS
QAETENEVHITVGVVRYDIDGRARSGGASGYLADRLEVDGDIRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQ
REVDGASGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQAHKIYVQDKLREQGAELWNWIQQGAHIYVCG
DANRMAKDVEQVLLDVVALHGAMDAEQADEYLSELRQARRYQRDVY
>Mature_605_residues
TTQAPPTSLLPLSPEQLARLQAAVGEFSPTQMAWLSGYFWGMVNQQPGAVASPAVAAPPPVTVTLISASQTGNARRLAEQ
LRDDLLAAQLSVNLVNAGDYKFKQIAQERLLVVVASTQGEGEPAEEAVALHKFLFSKKAPKLSETAFAVFGLGDTSYEHF
CQAGKDFDSKLAELGAQRLLDRVDADVEYQVQAQQWRQQVVATLQAKVPAQSTAPTQSTTPAAAAITSGGTTTVSPYSKT
APLTAQLSVQQKVTGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWFDNDPALVEELLALLWLKGDEPVSIDGQNMPLAQA
LLSHLELTQNTTLIVDKYAALSRDETLIALLADKPALQLYAKNTPFVDMVRQAPSDLNADQLVGLLRPLTPRLYSIASSQ
AETENEVHITVGVVRYDIDGRARSGGASGYLADRLEVDGDIRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQR
EVDGASGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQAHKIYVQDKLREQGAELWNWIQQGAHIYVCGD
ANRMAKDVEQVLLDVVALHGAMDAEQADEYLSELRQARRYQRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=602, Percent_Identity=31.3953488372093, Blast_Score=256, Evalue=5e-68,
Organism=Homo sapiens, GI24041029, Length=606, Percent_Identity=32.013201320132, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI7657393, Length=598, Percent_Identity=29.7658862876254, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI221316709, Length=597, Percent_Identity=29.6482412060301, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI221316705, Length=607, Percent_Identity=29.3245469522241, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI10835173, Length=649, Percent_Identity=28.3513097072419, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI221316707, Length=533, Percent_Identity=29.6435272045028, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI40254422, Length=649, Percent_Identity=28.5053929121726, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI169790956, Length=446, Percent_Identity=27.8026905829596, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI169790958, Length=446, Percent_Identity=27.8026905829596, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1789123, Length=606, Percent_Identity=73.9273927392739, Blast_Score=923, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17554134, Length=639, Percent_Identity=29.5774647887324, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17566446, Length=573, Percent_Identity=24.956369982548, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531441, Length=395, Percent_Identity=26.5822784810127, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321832, Length=639, Percent_Identity=28.169014084507, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321143, Length=394, Percent_Identity=31.7258883248731, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325305, Length=627, Percent_Identity=23.444976076555, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137192, Length=600, Percent_Identity=28.8333333333333, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24582192, Length=510, Percent_Identity=30, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24583543, Length=529, Percent_Identity=30.4347826086957, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI78706876, Length=529, Percent_Identity=30.4347826086957, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI78706872, Length=529, Percent_Identity=30.4347826086957, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24660907, Length=594, Percent_Identity=26.2626262626263, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24660903, Length=594, Percent_Identity=26.2626262626263, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 66626; Mature: 66495

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQAPPTSLLPLSPEQLARLQAAVGEFSPTQMAWLSGYFWGMVNQQPGAVASPAVAAPP
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
PVTVTLISASQTGNARRLAEQLRDDLLAAQLSVNLVNAGDYKFKQIAQERLLVVVASTQG
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCEEEEEEECCC
EGEPAEEAVALHKFLFSKKAPKLSETAFAVFGLGDTSYEHFCQAGKDFDSKLAELGAQRL
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHH
LDRVDADVEYQVQAQQWRQQVVATLQAKVPAQSTAPTQSTTPAAAAITSGGTTTVSPYSK
HHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEECCCCEEECCCCC
TAPLTAQLSVQQKVTGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWFDNDPALVEELLAL
CCCCEEEEEHHHHHCCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHH
LWLKGDEPVSIDGQNMPLAQALLSHLELTQNTTLIVDKYAALSRDETLIALLADKPALQL
HEECCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEECHHHCCCCCEEEEEEECCCCEEE
YAKNTPFVDMVRQAPSDLNADQLVGLLRPLTPRLYSIASSQAETENEVHITVGVVRYDID
EECCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEEEEEECC
GRARSGGASGYLADRLEVDGDIRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQ
CCCCCCCCCCEEEHHEECCCCEEEEEEECCCEECCCCCCCCEEEEECCCCHHHHHHHHHH
REVDGASGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQAHKIYVQDKLR
HCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHH
EQGAELWNWIQQGAHIYVCGDANRMAKDVEQVLLDVVALHGAMDAEQADEYLSELRQARR
HHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YQRDVY
HHHCCC
>Mature Secondary Structure 
TTQAPPTSLLPLSPEQLARLQAAVGEFSPTQMAWLSGYFWGMVNQQPGAVASPAVAAPP
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCC
PVTVTLISASQTGNARRLAEQLRDDLLAAQLSVNLVNAGDYKFKQIAQERLLVVVASTQG
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCEEEEEEECCC
EGEPAEEAVALHKFLFSKKAPKLSETAFAVFGLGDTSYEHFCQAGKDFDSKLAELGAQRL
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHH
LDRVDADVEYQVQAQQWRQQVVATLQAKVPAQSTAPTQSTTPAAAAITSGGTTTVSPYSK
HHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEECCCCEEECCCCC
TAPLTAQLSVQQKVTGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWFDNDPALVEELLAL
CCCCEEEEEHHHHHCCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHH
LWLKGDEPVSIDGQNMPLAQALLSHLELTQNTTLIVDKYAALSRDETLIALLADKPALQL
HEECCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEECHHHCCCCCEEEEEEECCCCEEE
YAKNTPFVDMVRQAPSDLNADQLVGLLRPLTPRLYSIASSQAETENEVHITVGVVRYDID
EECCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEEEEEECC
GRARSGGASGYLADRLEVDGDIRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQ
CCCCCCCCCCEEEHHEECCCCEEEEEEECCCEECCCCCCCCEEEEECCCCHHHHHHHHHH
REVDGASGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQAHKIYVQDKLR
HCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHH
EQGAELWNWIQQGAHIYVCGDANRMAKDVEQVLLDVVALHGAMDAEQADEYLSELRQARR
HHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YQRDVY
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA