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The map label for this gene is adk [H]

Identifier: 218930151

GI number: 218930151

Start: 3475023

End: 3475667

Strand: Reverse

Name: adk [H]

Synonym: YPO3118

Alternate gene names: 218930151

Gene position: 3475667-3475023 (Counterclockwise)

Preceding gene: 218930152

Following gene: 218930150

Centisome position: 74.69

GC content: 45.89

Gene sequence:

>645_bases
ATGCGTATCATTCTGCTGGGCGCTCCGGGCGCAGGTAAAGGTACTCAGGCTCAATTCATCATGGAGAAATACGGCATTCC
GCAAATCTCTACTGGTGACATGTTGCGCGCCGCTGTAAAAGCAGGTTCTGAGTTAGGTCTGAAAGCAAAAGAAATTATGG
ATGCGGGCAAGTTGGTGACTGATGAGTTAGTTATCGCATTAGTCAAAGAACGTATCACACAGGAAGATTGCCGCGATGGT
TTTCTGTTAGACGGGTTCCCGCGTACCATTCCTCAGGCAGATGCCATGAAAGAAGCCGGTATCAAAGTTGATTATGTGCT
GGAGTTTGATGTTCCAGACGAGCTGATTGTTGAGCGCATTGTCGGCCGTCGGGTACATGCTGCTTCAGGCCGTGTTTATC
ACGTTAAATTCAACCCACCTAAAGTTGAAGATAAAGATGATGTTACCGGTGAAGAGCTGACTATTCGTAAAGATGATCAG
GAAGCGACTGTCCGTAAGCGTCTTATCGAATATCATCAACAAACTGCACCATTGGTTTCTTACTATCATAAAGAAGCGGA
TGCAGGTAATACGCAATATTTTAAACTGGACGGAACCCGTAATGTAGCAGAAGTCAGTGCTGAACTGGCGACTATTCTCG
GTTAA

Upstream 100 bases:

>100_bases
AGCCAACCCCCCTGAAAATGGTATGGTTGCTTGTTTTCCACAATTTCTATTTATTTAAGTAAAAACACATAGAAAAACTA
CAAGCAAGGGGATTTACGCA

Downstream 100 bases:

>100_bases
TTCTGGATGGCCTTATAGCTAAGGCGGTTTAAGGCCGCCTTAGCTATTTCAAGTAAGAAGGGCGTAGTACCTACAAAAGG
AGATTTGGCATGATGCAAAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVTDELVIALVKERITQEDCRDG
FLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERIVGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQ
EATVRKRLIEYHQQTAPLVSYYHKEADAGNTQYFKLDGTRNVAEVSAELATILG

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVTDELVIALVKERITQEDCRDG
FLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERIVGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQ
EATVRKRLIEYHQQTAPLVSYYHKEADAGNTQYFKLDGTRNVAEVSAELATILG
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVTDELVIALVKERITQEDCRDG
FLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERIVGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQ
EATVRKRLIEYHQQTAPLVSYYHKEADAGNTQYFKLDGTRNVAEVSAELATILG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=200, Percent_Identity=51.5, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI4502013, Length=200, Percent_Identity=51.5, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=43.2432432432432, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=39.1304347826087, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=39.1304347826087, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=39.1304347826087, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=39.1304347826087, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=28.6486486486486, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=30.1369863013699, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI28144899, Length=213, Percent_Identity=27.6995305164319, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144897, Length=213, Percent_Identity=27.6995305164319, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI21450759, Length=151, Percent_Identity=26.4900662251656, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI237858799, Length=150, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=87.3831775700935, Blast_Score=382, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=46.3302752293578, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17537943, Length=187, Percent_Identity=33.1550802139037, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=34.5945945945946, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=29.5698924731183, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17533833, Length=186, Percent_Identity=27.9569892473118, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=219, Percent_Identity=46.1187214611872, Blast_Score=204, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=43.8144329896907, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=28.8770053475936, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=46.2616822429907, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=44.8648648648649, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=44.8648648648649, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17647141, Length=182, Percent_Identity=33.5164835164835, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24663208, Length=182, Percent_Identity=33.5164835164835, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=27.906976744186, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=27.906976744186, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23672; Mature: 23672

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVT
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHCHHHH
DELVIALVKERITQEDCRDGFLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERI
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHH
VGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQEATVRKRLIEYHQQTAPLVS
HCCCEECCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
YYHKEADAGNTQYFKLDGTRNVAEVSAELATILG
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVT
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHCHHHH
DELVIALVKERITQEDCRDGFLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERI
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHH
VGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQEATVRKRLIEYHQQTAPLVS
HCCCEECCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
YYHKEADAGNTQYFKLDGTRNVAEVSAELATILG
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA