Click here to switch to the map view.

The map label for this gene is tmcA

Identifier: 218930101

GI number: 218930101

Start: 3413013

End: 3415112

Strand: Reverse

Name: tmcA

Synonym: YPO3056

Alternate gene names: 218930101

Gene position: 3415112-3413013 (Counterclockwise)

Preceding gene: 218930102

Following gene: 218930095

Centisome position: 73.38

GC content: 55.19

Gene sequence:

>2100_bases
ATGACGAATCCAATCGTTGCCAGTCAACCACAGATGGCGCAGCAGGGGATCAGGCGTTTGCTGATCCTCAGTGGTCAGGC
CGATTGGTCACGGCAGCAGGCAATAATGCTACGCCAGCATCTGGCAGGCGATTGGCTATGGTTGAGCGAGCAGCCTCCCG
AAGGCGTCAACAGTATCAGTCCAACAGCGGCAAGAACTCTGTTGGGGCAGGAAAACTTACACGGCGTATTTGATGCAACC
GATGGGTTAAATATAGAAGCGCTAGCCATCGTCGCGGGGACCTTGCGGGCGGGGAGTTGGCTGCTATTGCTGGTGCCTGA
GTGGGATGACTGGCCGCAGCGGCCAGATAAAGACAGTTTGCGCTGGAGTGAGCAACCCGCTCCGATTGTCACAGCGAACT
TTATCCGCCACTTACAGCGCCAGTTTTTGGCTGATCCCGATGTGGTGCTGTGGCAGCAAGATCGGCCACTCATATTACCA
GCGGTTGGTTCTCGCCCATGTTGGCAGCAGCCAGACGGTTCACCAACCGCACAGCAACAGCATATTCTTCAGCGTCTGAT
GCAGGCAGATAGCGGTATTTGGGTACTGACAGCCGCTCGTGGGCGCGGTAAATCGACACTTGCCGGGATGTTAGTCACCC
ACTGGCAGGGGGCGTGTTGGGTGACCGGGCCGGGTAAAGCGGCCACTCAAGTGCTTAATCAACAAGCAGGGGAGCGGGCC
AGATTTTGGGCACCAGACGCACTGTTGGATTATTGCCAACGGCATGATGTCAGTGATATTGACTGGTTGTTGATTGATGA
AGCGGCGGCGATCCCGACACCGCTGTTATCGGCATTATTGGCGTATTTCCCCCGGGCATTATTGACCACCACGGTACAGG
GATATGAGGGCACGGGGCGTGGTTTTTTACTGAAATTCTGCGCGACACTGGGCGATTGGCATCATTTGACGCTGACGGAT
CCTATCCGCTGGGCCACGGATGATCCCTTGGAACGAGTGATGGATAATGCCATGTTGTTCCATGATGAATTACTCGGCAA
TCATCCCCTACCAAAGCGGCCACCTGTGGCGCAGATCGAAATCCCCCTTTATGAACAACGCGATTGGCGAGATAACCCGG
AGTTACTGCGGCGTTTTTATGGCTTACTCTCTACGGCTCATTACCGCACGACGCCGCTGGATTTACGCCGTCTGATGGAT
GCTCCGGGTATGCATTTCTCTGCCGCCAGAGTGGCCGATGCCGTGATTGGCGCATTATGGCTGGTGGATGAAGGGGGATT
GAGCGAGGCACTGGCCCTTGATGTCTGGGCGGGTCGGCGGCGGCCCAGAGGGAATCTGGTGGCACAATCACTGGCCGCTC
ATAGCGGGCAGTGGCAGGCACCAACGCTGTTATCGCGGCGTATCAGCCGGGTTGCTGTCACGGCAGCATGGCGGCAGCAA
GGAATTGCCCGCCGGATGATTGCCGCAGAACAGGCCCATGCCCGCCAGCAGCAGTGTGATTTTCTTTCGGTCAGTTTTGG
CTATACCGCCGAGTTGGCTCATTTTTGGCACCGCTGTGGTTTTCGTTTGGTACGTATTGGTAGCCATAAAGAGGCCAGTA
GCGGTTGTTATACCGCAATGGCGTTGTTACCTCTTAGTCCCGCGGGGGAGGCACTCTGTCAGGCGGCGCAGCAGCAGTTA
AAACGTGATTGGTATTGGTTACAGCAATGGATTGGCATACCAACCCCGGTATTTTTACGGCTACCTGAACCGCCGGAGGT
CACGTTAACTGACGACGATTGGCGGGAACTGGCAGGATTTGCTTTTGCTTTTCGCCCATTAGAGGCCAGTTTACCGGCGC
TACAACGGTTGTTATTACACACCGAGTTACCCCTTTCGGCGTTACGACACTATTTGCAGTTACGCACTCCTCAGTCTGAG
ATTATCAATACCCTTGGTTTGATAGGGCGTAAGGCATTGGTGGCACTGTGGCGTCAGGAAGCCGCCGAGGGGATGGCAAT
GATTGATGTGGATAAAATGATCATGTCTGCCAAACCATCGGCGCGGTGTAGCACTGTCCGGTTACCCGGTAGAAAAAACC
TTACGATATGCCAATGCTAA

Upstream 100 bases:

>100_bases
CTGGTAGGAACGGTGCTCGGCGTCGCCTTGTTCAAAGGCGTCCCTGTCGGGCCATTGATTGCCGCCGGTTTGCTCTCACT
GGTCATAGGCAAGTCGTAAG

Downstream 100 bases:

>100_bases
TACCAGCGGTGCGTTAGCGGTTTCGCACAAAGGCCCAATGGAAGGTTTATCCAGTCTTAGGCAAATCGAGCAGTGTATCC
TAGAGCAATCCCACGCAGGT

Product: putative acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MTNPIVASQPQMAQQGIRRLLILSGQADWSRQQAIMLRQHLAGDWLWLSEQPPEGVNSISPTAARTLLGQENLHGVFDAT
DGLNIEALAIVAGTLRAGSWLLLLVPEWDDWPQRPDKDSLRWSEQPAPIVTANFIRHLQRQFLADPDVVLWQQDRPLILP
AVGSRPCWQQPDGSPTAQQQHILQRLMQADSGIWVLTAARGRGKSTLAGMLVTHWQGACWVTGPGKAATQVLNQQAGERA
RFWAPDALLDYCQRHDVSDIDWLLIDEAAAIPTPLLSALLAYFPRALLTTTVQGYEGTGRGFLLKFCATLGDWHHLTLTD
PIRWATDDPLERVMDNAMLFHDELLGNHPLPKRPPVAQIEIPLYEQRDWRDNPELLRRFYGLLSTAHYRTTPLDLRRLMD
APGMHFSAARVADAVIGALWLVDEGGLSEALALDVWAGRRRPRGNLVAQSLAAHSGQWQAPTLLSRRISRVAVTAAWRQQ
GIARRMIAAEQAHARQQQCDFLSVSFGYTAELAHFWHRCGFRLVRIGSHKEASSGCYTAMALLPLSPAGEALCQAAQQQL
KRDWYWLQQWIGIPTPVFLRLPEPPEVTLTDDDWRELAGFAFAFRPLEASLPALQRLLLHTELPLSALRHYLQLRTPQSE
IINTLGLIGRKALVALWRQEAAEGMAMIDVDKMIMSAKPSARCSTVRLPGRKNLTICQC

Sequences:

>Translated_699_residues
MTNPIVASQPQMAQQGIRRLLILSGQADWSRQQAIMLRQHLAGDWLWLSEQPPEGVNSISPTAARTLLGQENLHGVFDAT
DGLNIEALAIVAGTLRAGSWLLLLVPEWDDWPQRPDKDSLRWSEQPAPIVTANFIRHLQRQFLADPDVVLWQQDRPLILP
AVGSRPCWQQPDGSPTAQQQHILQRLMQADSGIWVLTAARGRGKSTLAGMLVTHWQGACWVTGPGKAATQVLNQQAGERA
RFWAPDALLDYCQRHDVSDIDWLLIDEAAAIPTPLLSALLAYFPRALLTTTVQGYEGTGRGFLLKFCATLGDWHHLTLTD
PIRWATDDPLERVMDNAMLFHDELLGNHPLPKRPPVAQIEIPLYEQRDWRDNPELLRRFYGLLSTAHYRTTPLDLRRLMD
APGMHFSAARVADAVIGALWLVDEGGLSEALALDVWAGRRRPRGNLVAQSLAAHSGQWQAPTLLSRRISRVAVTAAWRQQ
GIARRMIAAEQAHARQQQCDFLSVSFGYTAELAHFWHRCGFRLVRIGSHKEASSGCYTAMALLPLSPAGEALCQAAQQQL
KRDWYWLQQWIGIPTPVFLRLPEPPEVTLTDDDWRELAGFAFAFRPLEASLPALQRLLLHTELPLSALRHYLQLRTPQSE
IINTLGLIGRKALVALWRQEAAEGMAMIDVDKMIMSAKPSARCSTVRLPGRKNLTICQC
>Mature_698_residues
TNPIVASQPQMAQQGIRRLLILSGQADWSRQQAIMLRQHLAGDWLWLSEQPPEGVNSISPTAARTLLGQENLHGVFDATD
GLNIEALAIVAGTLRAGSWLLLLVPEWDDWPQRPDKDSLRWSEQPAPIVTANFIRHLQRQFLADPDVVLWQQDRPLILPA
VGSRPCWQQPDGSPTAQQQHILQRLMQADSGIWVLTAARGRGKSTLAGMLVTHWQGACWVTGPGKAATQVLNQQAGERAR
FWAPDALLDYCQRHDVSDIDWLLIDEAAAIPTPLLSALLAYFPRALLTTTVQGYEGTGRGFLLKFCATLGDWHHLTLTDP
IRWATDDPLERVMDNAMLFHDELLGNHPLPKRPPVAQIEIPLYEQRDWRDNPELLRRFYGLLSTAHYRTTPLDLRRLMDA
PGMHFSAARVADAVIGALWLVDEGGLSEALALDVWAGRRRPRGNLVAQSLAAHSGQWQAPTLLSRRISRVAVTAAWRQQG
IARRMIAAEQAHARQQQCDFLSVSFGYTAELAHFWHRCGFRLVRIGSHKEASSGCYTAMALLPLSPAGEALCQAAQQQLK
RDWYWLQQWIGIPTPVFLRLPEPPEVTLTDDDWRELAGFAFAFRPLEASLPALQRLLLHTELPLSALRHYLQLRTPQSEI
INTLGLIGRKALVALWRQEAAEGMAMIDVDKMIMSAKPSARCSTVRLPGRKNLTICQC

Specific function: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP)

COG id: COG1444

COG function: function code R; Predicted P-loop ATPase fused to an acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain

Homologues:

Organism=Escherichia coli, GI1788818, Length=662, Percent_Identity=51.963746223565, Blast_Score=626, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17507621, Length=362, Percent_Identity=25.1381215469613, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640662, Length=335, Percent_Identity=24.7761194029851, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TMCA_YERPD (D0JFM7)

Other databases:

- EMBL:   CP001585
- EMBL:   CP001585
- GenomeReviews:   CP001585_GR
- GO:   GO:0005737
- HAMAP:   MF_01886
- InterPro:   IPR013562
- InterPro:   IPR007807

Pfam domain/function: PF08351 DUF1726; PF05127 DUF699

EC number: NA

Molecular weight: Translated: 78264; Mature: 78133

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS51186 GNAT

Important sites: BINDING 179-179 BINDING 323-323 BINDING 511-511 BINDING 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPIVASQPQMAQQGIRRLLILSGQADWSRQQAIMLRQHLAGDWLWLSEQPPEGVNSIS
CCCCCCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
PTAARTLLGQENLHGVFDATDGLNIEALAIVAGTLRAGSWLLLLVPEWDDWPQRPDKDSL
HHHHHHHHCCCCCCEEEECCCCCCEEEHEEEHHHHCCCCEEEEEECCCCCCCCCCCCCCC
RWSEQPAPIVTANFIRHLQRQFLADPDVVLWQQDRPLILPAVGSRPCWQQPDGSPTAQQQ
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHH
HILQRLMQADSGIWVLTAARGRGKSTLAGMLVTHWQGACWVTGPGKAATQVLNQQAGERA
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCC
RFWAPDALLDYCQRHDVSDIDWLLIDEAAAIPTPLLSALLAYFPRALLTTTVQGYEGTGR
CCCCCHHHHHHHHHCCCCCCCEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GFLLKFCATLGDWHHLTLTDPIRWATDDPLERVMDNAMLFHDELLGNHPLPKRPPVAQIE
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IPLYEQRDWRDNPELLRRFYGLLSTAHYRTTPLDLRRLMDAPGMHFSAARVADAVIGALW
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LVDEGGLSEALALDVWAGRRRPRGNLVAQSLAAHSGQWQAPTLLSRRISRVAVTAAWRQQ
EECCCCCCHHHEEEHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GIARRMIAAEQAHARQQQCDFLSVSFGYTAELAHFWHRCGFRLVRIGSHKEASSGCYTAM
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
ALLPLSPAGEALCQAAQQQLKRDWYWLQQWIGIPTPVFLRLPEPPEVTLTDDDWRELAGF
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCHHHHHHHHH
AFAFRPLEASLPALQRLLLHTELPLSALRHYLQLRTPQSEIINTLGLIGRKALVALWRQE
HHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAEGMAMIDVDKMIMSAKPSARCSTVRLPGRKNLTICQC
HHCCCEEEEHHHHHHHCCCCCCCEEEECCCCCCCEEECC
>Mature Secondary Structure 
TNPIVASQPQMAQQGIRRLLILSGQADWSRQQAIMLRQHLAGDWLWLSEQPPEGVNSIS
CCCCCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
PTAARTLLGQENLHGVFDATDGLNIEALAIVAGTLRAGSWLLLLVPEWDDWPQRPDKDSL
HHHHHHHHCCCCCCEEEECCCCCCEEEHEEEHHHHCCCCEEEEEECCCCCCCCCCCCCCC
RWSEQPAPIVTANFIRHLQRQFLADPDVVLWQQDRPLILPAVGSRPCWQQPDGSPTAQQQ
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHH
HILQRLMQADSGIWVLTAARGRGKSTLAGMLVTHWQGACWVTGPGKAATQVLNQQAGERA
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCC
RFWAPDALLDYCQRHDVSDIDWLLIDEAAAIPTPLLSALLAYFPRALLTTTVQGYEGTGR
CCCCCHHHHHHHHHCCCCCCCEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GFLLKFCATLGDWHHLTLTDPIRWATDDPLERVMDNAMLFHDELLGNHPLPKRPPVAQIE
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IPLYEQRDWRDNPELLRRFYGLLSTAHYRTTPLDLRRLMDAPGMHFSAARVADAVIGALW
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LVDEGGLSEALALDVWAGRRRPRGNLVAQSLAAHSGQWQAPTLLSRRISRVAVTAAWRQQ
EECCCCCCHHHEEEHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GIARRMIAAEQAHARQQQCDFLSVSFGYTAELAHFWHRCGFRLVRIGSHKEASSGCYTAM
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
ALLPLSPAGEALCQAAQQQLKRDWYWLQQWIGIPTPVFLRLPEPPEVTLTDDDWRELAGF
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCHHHHHHHHH
AFAFRPLEASLPALQRLLLHTELPLSALRHYLQLRTPQSEIINTLGLIGRKALVALWRQE
HHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAEGMAMIDVDKMIMSAKPSARCSTVRLPGRKNLTICQC
HHCCCEEEEHHHHHHHCCCCCCCEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA