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The map label for this gene is yfeC

Identifier: 218929530

GI number: 218929530

Start: 2740597

End: 2741481

Strand: Direct

Name: yfeC

Synonym: YPO2441

Alternate gene names: 218929530

Gene position: 2740597-2741481 (Clockwise)

Preceding gene: 218929529

Following gene: 218929531

Centisome position: 58.89

GC content: 46.89

Gene sequence:

>885_bases
ATGCTGGAACTTTTACTGCAACCGTTTAATTATAATTATATGGTCAAGGCCATTTGGGTTAGTGCGATTGTGGGGGCCGT
TTGTGCTTTTCTATCCGCTTATCTGATGCTAAAAGGCTGGTCGCTGATGGGTGATGCGTTATCACACTCAGTCGTGCCTG
GGGTTGCAGGGGCTTATGCTCTTGGTTTTCCCTATGCCGCTGGCGCTTTCTTTACGGGTATGCTTGCCGCCTTGGCAATG
ACGCTAGTACGCCACATTACCCGCCTACGTGAAGATGCCATTATCGGTTTTATCTTTTCTACCTTTTTTGCTGTTGGGCT
TTTAATCGTTTCACTCAATCCCACATCAGTGAATGTTCAGTCGATCATCTTCGGCAATATTCTGGGTATTGCTGATGAAG
ATGTCTTGCAGGTAGAAATCATTATTTTGGTTTCTTTTGTGATTTTATGTTTGATCTGGAAAGATTTATTAGCGGTGTTT
TTCGATGAAAGCCACGCCATGTCAATTGGTTTATCCCCACTGCGCTTAAAAATCTTATTCTTTACGCTCCTGAGCGCCTG
TACTGTCGCCGCTTTACAAACCGTGGGGGCCATTTTAGTGATAGCTATGGTCGTCACTCCAGGGGCAACAGCCTATTTAC
TGACCGATCGTTTCGGCCGCTTGCTCATTATTGCCATTGCTATTGGGGCCATTACCAGTGCTTTCGGCGCGTATCTCAGT
TTTTATCTGGATGGGGCAACCGGTGGCGTTATTGTCACCTTACAAACACTGGTATTCCTGCCGGCTTTCTTCTTTGCCCC
CAAACACGGATTACTGGCAACCCGATACCGCACACGGTTGAAACGTCGTCATCCGCCGGTTCATCTTCCGGAGGATAACC
TATGA

Upstream 100 bases:

>100_bases
CCGTCACCGTAATAACTGATGATGAACGCCCCGCAGTATTTTATGGTCATACTAAAAATGATCCGCCTGCACAAAGCCAG
TCAAAGGAGCAAAATTCCTG

Downstream 100 bases:

>100_bases
ATATGCTGTTCAGTTTGATCAGTGAGCCATTCGCCTACCCCTTTATGCAGCGGGCAATTGTCGCGGCAATCGTCACTGGT
GTGGTCTGCGCGATACTCTC

Product: chelated iron transport system membrane protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MLELLLQPFNYNYMVKAIWVSAIVGAVCAFLSAYLMLKGWSLMGDALSHSVVPGVAGAYALGFPYAAGAFFTGMLAALAM
TLVRHITRLREDAIIGFIFSTFFAVGLLIVSLNPTSVNVQSIIFGNILGIADEDVLQVEIIILVSFVILCLIWKDLLAVF
FDESHAMSIGLSPLRLKILFFTLLSACTVAALQTVGAILVIAMVVTPGATAYLLTDRFGRLLIIAIAIGAITSAFGAYLS
FYLDGATGGVIVTLQTLVFLPAFFFAPKHGLLATRYRTRLKRRHPPVHLPEDNL

Sequences:

>Translated_294_residues
MLELLLQPFNYNYMVKAIWVSAIVGAVCAFLSAYLMLKGWSLMGDALSHSVVPGVAGAYALGFPYAAGAFFTGMLAALAM
TLVRHITRLREDAIIGFIFSTFFAVGLLIVSLNPTSVNVQSIIFGNILGIADEDVLQVEIIILVSFVILCLIWKDLLAVF
FDESHAMSIGLSPLRLKILFFTLLSACTVAALQTVGAILVIAMVVTPGATAYLLTDRFGRLLIIAIAIGAITSAFGAYLS
FYLDGATGGVIVTLQTLVFLPAFFFAPKHGLLATRYRTRLKRRHPPVHLPEDNL
>Mature_294_residues
MLELLLQPFNYNYMVKAIWVSAIVGAVCAFLSAYLMLKGWSLMGDALSHSVVPGVAGAYALGFPYAAGAFFTGMLAALAM
TLVRHITRLREDAIIGFIFSTFFAVGLLIVSLNPTSVNVQSIIFGNILGIADEDVLQVEIIILVSFVILCLIWKDLLAVF
FDESHAMSIGLSPLRLKILFFTLLSACTVAALQTVGAILVIAMVVTPGATAYLLTDRFGRLLIIAIAIGAITSAFGAYLS
FYLDGATGGVIVTLQTLVFLPAFFFAPKHGLLATRYRTRLKRRHPPVHLPEDNL

Specific function: Part of an ATP-driven transport system yfeABC for chelated iron

COG id: COG1108

COG function: function code P; ABC-type Mn2+/Zn2+ transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-3 integral membrane protein family

Homologues:

Organism=Escherichia coli, GI1788166, Length=246, Percent_Identity=26.0162601626016, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YFEC_YERPE (Q56954)

Other databases:

- EMBL:   U50597
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0298
- RefSeq:   NP_669211.1
- RefSeq:   NP_993558.1
- RefSeq:   YP_002347405.1
- ProteinModelPortal:   Q56954
- IntAct:   Q56954
- GeneID:   1146842
- GeneID:   1175275
- GeneID:   2764789
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2441
- KEGG:   ypk:y1895
- KEGG:   ypm:YP_2229
- HOGENOM:   HBG733179
- OMA:   CAFLSSY
- ProtClustDB:   CLSK889183
- BioCyc:   YPES187410:Y1895-MONOMER
- BioCyc:   YPES214092:YPO2441-MONOMER
- InterPro:   IPR001626

Pfam domain/function: PF00950 ABC-3

EC number: NA

Molecular weight: Translated: 31807; Mature: 31807

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x4cf98874)-; HASH(0x4d1b33ec)-; HASH(0x4d02c8f4)-; HASH(0x4d074a14)-; HASH(0x4d0ad888)-; HASH(0x4d11807c)-; HASH(0x4d18fc44)-; HASH(0x4d18f5d8)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELLLQPFNYNYMVKAIWVSAIVGAVCAFLSAYLMLKGWSLMGDALSHSVVPGVAGAYA
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHH
LGFPYAAGAFFTGMLAALAMTLVRHITRLREDAIIGFIFSTFFAVGLLIVSLNPTSVNVQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SIIFGNILGIADEDVLQVEIIILVSFVILCLIWKDLLAVFFDESHAMSIGLSPLRLKILF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHH
FTLLSACTVAALQTVGAILVIAMVVTPGATAYLLTDRFGRLLIIAIAIGAITSAFGAYLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLDGATGGVIVTLQTLVFLPAFFFAPKHGLLATRYRTRLKRRHPPVHLPEDNL
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure
MLELLLQPFNYNYMVKAIWVSAIVGAVCAFLSAYLMLKGWSLMGDALSHSVVPGVAGAYA
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHH
LGFPYAAGAFFTGMLAALAMTLVRHITRLREDAIIGFIFSTFFAVGLLIVSLNPTSVNVQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SIIFGNILGIADEDVLQVEIIILVSFVILCLIWKDLLAVFFDESHAMSIGLSPLRLKILF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHH
FTLLSACTVAALQTVGAILVIAMVVTPGATAYLLTDRFGRLLIIAIAIGAITSAFGAYLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLDGATGGVIVTLQTLVFLPAFFFAPKHGLLATRYRTRLKRRHPPVHLPEDNL
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9495751; 11586360; 12142430