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The map label for this gene is sufS [H]

Identifier: 218929490

GI number: 218929490

Start: 2696410

End: 2697630

Strand: Reverse

Name: sufS [H]

Synonym: YPO2400

Alternate gene names: 218929490

Gene position: 2697630-2696410 (Counterclockwise)

Preceding gene: 284987069

Following gene: 218929489

Centisome position: 57.97

GC content: 51.84

Gene sequence:

>1221_bases
ATGAATTTTCCTATTGAACGTGTAAGAGCTGATTTTCCACTGTTGAGCCGCCAGGTTAATGGGCAGCCGTTGGTTTATCT
GGACAGCGCAGCCAGTGCGCAAAAACCTCAGGCGGTCATTGACAAGGAGCTTCATTTTTACCGTGATGGTTATGCGGCCG
TTCATAGGGGCATTCACAGTTTAAGTGCTGAAGCGACTCAGCAGATGGAAGCCGTACGCACTCAGGTGGCTGATTTTATT
CACGCCGCCTCCGCAGAAGAAATTATTTTTGTCAGAGGCACCACTGAAGCAATCAATTTGGTTGCTAACAGTTATGGCCG
CCATTTCCTTGCCGCGGGTGATAGCATTATCATTACCGAAATGGAACACCATGCCAATATTGTGCCTTGGCAGATGTTGG
CGCAAGATCTTGGTGTTGAAATCCGTGTTTGGCCACTGACGGCTACCGGTGAGTTGGAGATAACCGCCCTGGCAGCGTTG
ATTGATGACACCACGCGCTTACTGGCGGTGACTCAGGTCTCCAACGTGTTGGGAACGGTAAACCCGATTAAGGATATTGT
GGCCCAGGCAAAAGCCGCCGGTTTAGTGGTGTTGGTGGATGGTGCGCAAGCGGTTATGCATCAGCCAGTTGATGTTCAGG
CGTTGGGCTGCGATTTTTATGTTTTCTCAGGGCACAAACTGTACGGCCCATCGGGTATTGGGATTCTGTACGGCAAAAGT
GCGTTGTTACAACAGATGCCGCCATGGGAAGGGGGCGGGGCGATGATCAAAACAGTCAGTTTGACGCAAGGCACTACGTT
TGCTGACGCCCCTTGGCGCTTTGAGGCTGGGTCACCTAATACTGCGGGTATCATGGGGCTTGGCGCGGCCATTGACTATG
TCACTGAATTGGGGCTCTTGCCGATCCAACAGTATGAGCAATCGCTGATGCATTACGCATTGGCGCAACTGAGCCAGATT
AAGAGCCTGACACTGTATGGCCCAACAGAGCGTGCCGGGGTTATTGCCTTCAATCTGGGCCAGCACCATGCCTATGATGT
GGGCAGCTTTCTTGACCAATACGGTATTGCTATTCGTACGGGTCATCACTGTGCGATGCCGCTGATGGCATTCTATCAGG
TACCGAGTATGTGCCGTGCCTCACTGGCGCTGTATAATACCCGCGAGGATGTTGATCGGTTGGTGGCAGGATTACAGCGT
ATCGAAAAATTGCTGGGGTGA

Upstream 100 bases:

>100_bases
TTTTTGCATTTGCTGCTGAAGTGACTGAAGCTATCCACAATGAAGCCATCCGTAAACAGGTGTTAGCACGTATTGCTGAG
CGTTTGGCGTGGGAGTCTGT

Downstream 100 bases:

>100_bases
GAGTCTAAGCACCCACAACAGGCAACACCAAAGCCGACTATTCTTTCAGCAGTCGGCTTTTATTTTTTACGTATTCAGGA
AATATGCTATGGCTGGTTTG

Product: bifunctional cysteine desulfurase/selenocysteine lyase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHSLSAEATQQMEAVRTQVADFI
HAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITEMEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAAL
IDDTTRLLAVTQVSNVLGTVNPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKS
ALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLLPIQQYEQSLMHYALAQLSQI
KSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQR
IEKLLG

Sequences:

>Translated_406_residues
MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHSLSAEATQQMEAVRTQVADFI
HAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITEMEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAAL
IDDTTRLLAVTQVSNVLGTVNPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKS
ALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLLPIQQYEQSLMHYALAQLSQI
KSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQR
IEKLLG
>Mature_406_residues
MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHSLSAEATQQMEAVRTQVADFI
HAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITEMEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAAL
IDDTTRLLAVTQVSNVLGTVNPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKS
ALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLLPIQQYEQSLMHYALAQLSQI
KSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQR
IEKLLG

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=298, Percent_Identity=27.5167785234899, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI156713448, Length=268, Percent_Identity=30.5970149253731, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=70.4433497536946, Blast_Score=609, Evalue=1e-176,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=43.5960591133005, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI48994898, Length=215, Percent_Identity=31.6279069767442, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=216, Percent_Identity=30.5555555555556, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=382, Percent_Identity=24.6073298429319, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319831, Length=233, Percent_Identity=30.9012875536481, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20129463, Length=242, Percent_Identity=30.5785123966942, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 44025; Mature: 44025

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHS
CCCCHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
LSAEATQQMEAVRTQVADFIHAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITE
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEEECCCEEEEEE
MEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAALIDDTTRLLAVTQVSNVLGTV
EHHCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHCCC
NPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKS
HHHHHHHHHHHHCCEEEEECCCHHHHCCCCCEEEECEEEEEEECCEEECCCCCEEEECCH
ALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLL
HHHHCCCCCCCCCCEEEEEEEECCCEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCC
PIQQYEQSLMHYALAQLSQIKSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRT
CHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEC
GHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQRIEKLLG
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHS
CCCCHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
LSAEATQQMEAVRTQVADFIHAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITE
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEEECCCEEEEEE
MEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAALIDDTTRLLAVTQVSNVLGTV
EHHCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHCCC
NPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKS
HHHHHHHHHHHHCCEEEEECCCHHHHCCCCCEEEECEEEEEEECCEEECCCCCEEEECCH
ALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLL
HHHHCCCCCCCCCCEEEEEEEECCCEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCC
PIQQYEQSLMHYALAQLSQIKSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRT
CHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEC
GHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQRIEKLLG
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA