Click here to switch to the map view.

The map label for this gene is tppB

Identifier: 218929453

GI number: 218929453

Start: 2655080

End: 2656585

Strand: Direct

Name: tppB

Synonym: YPO2361

Alternate gene names: 218929453

Gene position: 2655080-2656585 (Clockwise)

Preceding gene: 218929452

Following gene: 218929454

Centisome position: 57.05

GC content: 48.07

Gene sequence:

>1506_bases
GTGTCAACAGCAAACAACAACCAACCAGAAAGCATCAGTATGAACGCTTTCAAACAACCAAAAGCGTTTTATCTTATTTT
CTCTATAGAACTTTGGGAGCGCTTTGGTTACTACGGCCTGCAAGGGATCATGGCTGTCTACCTGGTAAAAATGCTCGGGA
TGAGCGAAGCCGATTCAATCACCTTGTTCTCCTCATTCAGCGCCTTGGTGTATGGTTTTGTCGCCATTGGTGGCTGGTTA
GGCGATAAAGTCCTTGGGGCGAAGCGGGTTATTGTCCTTGGTGCACTCACGCTAGCGGTCGGTTATTCCATGATAGCCTA
CTCCGGCCACGAGATTTTCTGGGTTTATCTGGGCATGGCAACCATTGCCGTTGGTAATGGCTTATTTAAAGCCAACCCTT
CATCTCTACTTTCAACCTGCTACAGCAAGGACGATCCGCGTTTGGACGGTGCATTTACCATGTACTATATGTCCATCAAT
ATCGGTTCGTTCTTCTCTATGTTGGCAACCCCATGGCTGGCGGCTAAATATGGCTGGAGCGTTGCGTTTTCTCTGAGCGT
TGTGGGGATGTTGATTACACTGGTCAATTTCTGGTTCTGCCGTAAATGGGTAAAAAACCAAGGCTCCAAACCAGACTTTC
TCCCTCTGCAATTTAAAAAATTACTGATGGTCTTAGTGGGTATTATCGCGTTGATAACCCTTTCCAACTGGTTACTCCAC
AACCAGATTATTGCACGCTGGGCGCTGGCACTGGTCTCCCTAGGGATTATCTTCATCTTTACCAAAGAAACGCTCTTCCT
GCAGGGCATTGCGCGCCGCAGAATGATTGTCGCCTTCTTGTTGATGCTGGAAGCGGTCATTTTCTTTGTGCTATACAGCC
AAATGCCAACCTCACTGAACTTCTTCGCTATCCACAATGTGGAGCACTCAATCTTTGGCATTGGTTTTGAACCAGAACAA
TTTCAGGCACTGAATCCCTTCTGGATCATGCTTGCCAGCCCTATTTTGGCGGCTATCTATAATAAGATGGGCGACCGTCT
ACCAATGCCTCATAAGTTTGCCTTTGGTATGATGCTCTGCTCCGCTGCCTTCTTGGTGCTGCCATGGGGAGCAAGCTTTG
CTAATGAACACGGTATTGTGTCTGTTAACTGGCTTATCTTAAGTTATGCACTGCAGAGTATCGGTGAGTTGATGATCTCC
GGCTTAGGTCTGGCCATGGTTGCTCAATTGGTACCTCAGCGTTTAATGGGCTTCATCATGGGGTCATGGTTCCTGACTAC
CGCGGCCGCGGCTCTGATCGCGGGTAAAGTGGCCGCATTGACTGCGGTCCCAAGTGATGCCATCACTGACGCACATGCAT
CCCTGGCGATTTATAGCCACGTATTTATGCAAATTGGTATTGTGACCGCCATTATCGCCGTACTGATGATGCTGACTGCA
CCGAAACTGTATCGTATGACGCTGGCCCCTAGCGATCACAACGATGTCAAAATCATGACCCAATAA

Upstream 100 bases:

>100_bases
GCCGCTAATCATCTTATAACAACACAAAAGGGCGTGATTTTCACATTCACTTTTGTCTTTCCTGTCAGTTATGACCGGTA
GTGAAAAATTAGAGGTCCCA

Downstream 100 bases:

>100_bases
GCTGACTAAACGCGCTCCTGCGGGAGCGCTTTTAGTGCTAGTTAGGTGCCCCGACCTGCACACCTGCCCCCCTACACAAC
AACAGATTGCTCAAAAAAAC

Product: putative tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSITLFSSFSALVYGFVAIGGWL
GDKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDGAFTMYYMSIN
IGSFFSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIALITLSNWLLH
NQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLNFFAIHNVEHSIFGIGFEPEQ
FQALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYALQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTAIIAVLMMLTA
PKLYRMTLAPSDHNDVKIMTQ

Sequences:

>Translated_501_residues
MSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSITLFSSFSALVYGFVAIGGWL
GDKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDGAFTMYYMSIN
IGSFFSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIALITLSNWLLH
NQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLNFFAIHNVEHSIFGIGFEPEQ
FQALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYALQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTAIIAVLMMLTA
PKLYRMTLAPSDHNDVKIMTQ
>Mature_500_residues
STANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSITLFSSFSALVYGFVAIGGWLG
DKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMATIAVGNGLFKANPSSLLSTCYSKDDPRLDGAFTMYYMSINI
GSFFSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIALITLSNWLLHN
QIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLNFFAIHNVEHSIFGIGFEPEQF
QALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLCSAAFLVLPWGASFANEHGIVSVNWLILSYALQSIGELMISG
LGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTAIIAVLMMLTAP
KLYRMTLAPSDHNDVKIMTQ

Specific function: Proton-dependent permease that transports di- and tripeptides

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily

Homologues:

Organism=Homo sapiens, GI4827008, Length=387, Percent_Identity=22.9974160206718, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787922, Length=487, Percent_Identity=75.7700205338809, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=493, Percent_Identity=51.7241379310345, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1786927, Length=479, Percent_Identity=30.4801670146138, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1790572, Length=473, Percent_Identity=30.4439746300211, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17541704, Length=397, Percent_Identity=23.4256926952141, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569141, Length=372, Percent_Identity=25.2688172043011, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71987453, Length=379, Percent_Identity=22.9551451187335, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639585, Length=346, Percent_Identity=25.4335260115607, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639581, Length=344, Percent_Identity=26.453488372093, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24639583, Length=331, Percent_Identity=25.9818731117825, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571098, Length=391, Percent_Identity=24.2966751918159, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571102, Length=389, Percent_Identity=24.1645244215938, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571100, Length=389, Percent_Identity=24.1645244215938, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTPA_YERPE (Q0WEG0)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0288
- RefSeq:   YP_002347328.1
- ProteinModelPortal:   Q0WEG0
- GeneID:   1175193
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2361
- KEGG:   ypk:y1971
- KEGG:   ypm:YP_2150
- HOGENOM:   HBG586603
- OMA:   VFFVLYS
- ProtClustDB:   PRK09584
- HAMAP:   MF_01878
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456
- PANTHER:   PTHR11654:SF6
- TIGRFAMs:   TIGR00924

Pfam domain/function: PF00854 PTR2; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 55314; Mature: 55182

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50850 MFS; PS01022 PTR2_1; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd7ffd88)-; HASH(0x4d08d62c)-; HASH(0xdc4e564)-; HASH(0x4d0a0844)-; HASH(0x4d09fae8)-; HASH(0x4d090c5c)-; HASH(0x4ce96214)-; HASH(0x4cfb0034)-; HASH(0x4d0d5aa0)-; HASH(0x4cf9e130)-; HASH(0x4d09faf4)-; HASH(0x4ceab5a4)-; HASH(0x4cfe2734)-; HASH(0x4cf95eec)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSI
CCCCCCCCCCCEECCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
TLFSSFSALVYGFVAIGGWLGDKVLGAKRVIVLGALTLAVGYSMIAYSGHEIFWVYLGMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
TIAVGNGLFKANPSSLLSTCYSKDDPRLDGAFTMYYMSINIGSFFSMLATPWLAAKYGWS
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEECHHHHHHHHHCHHHHHHHCCH
VAFSLSVVGMLITLVNFWFCRKWVKNQGSKPDFLPLQFKKLLMVLVGIIALITLSNWLLH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NQIIARWALALVSLGIIFIFTKETLFLQGIARRRMIVAFLLMLEAVIFFVLYSQMPTSLN
HHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FFAIHNVEHSIFGIGFEPEQFQALNPFWIMLASPILAAIYNKMGDRLPMPHKFAFGMMLC
EEEEECCCHHEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SAAFLVLPWGASFANEHGIVSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIM
HHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GSWFLTTAAAALIAGKVAALTAVPSDAITDAHASLAIYSHVFMQIGIVTAIIAVLMMLTA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKLYRMTLAPSDHNDVKIMTQ
CHHEEEEECCCCCCCEEEEEH
>Mature Secondary Structure 
STANNNQPESISMNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGMSEADSI
CCCCCCCCCCEECCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC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CHHEEEEECCCCCCCEEEEEH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430