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The map label for this gene is dalD

Identifier: 218929417

GI number: 218929417

Start: 2614917

End: 2616308

Strand: Direct

Name: dalD

Synonym: YPO2325

Alternate gene names: 218929417

Gene position: 2614917-2616308 (Clockwise)

Preceding gene: 218929415

Following gene: 218929421

Centisome position: 56.19

GC content: 50.36

Gene sequence:

>1392_bases
ATGAATACTGACCTGAAATCACCCCCTGCTGTGTGGCTGCATATTGGTGCTGGCTCCTTCCACCGAGCCCATCAGGCTTG
GTATTTACACCGTTTGTTAGCCTCAGGCGATGACCGTTGGACTATCGCTTTGGCCAATATTCGTGATGACGCCATCCCAC
TACTGGACACATTGCGGGCGCAACACGGTGAATATGTCTTGGAAACGGTCACACCAAGCGGTGAACGCCAGTATGAAAAG
ATAACATCACTGCGCAATATCATTCCTTGGGATAAAGCGCTAGATCATCTGGTAGCGCAAGGGAGTAAACCCGAAACTCG
CGTGATCTCTTTCACCGTAACGGAGGGGGGCTACTATTTAGATAATCAATTTAATCTGCAACAGGACAATAGCGATATTC
AGGCCGATCTTAGAGGAGATTGCCGCACGATTTACGGGGCAATTAGCCGTATCTTGCAACAACGGCAACAGGATAAGAGT
GGCCCGGTCACTCTACTGAACTGCGATAACTTGCGTCACAACGGTGAACGATTCCGCCATGGCTTATTAGAGTTTCTTGC
TCTACGAGGTCAACAAAGCCTATTAAACTGGGTGACAAGCCAGACCCGCAGCCCGAATACCATGGTTGATCGTATCACCC
CGCGCCCATCAGCCGATATCGCGCAGCGGGTGTTGGAAAAAACCGGTATCGTAGATAACGCTCCGGTGATGGGGGAATCA
TTTATTCAATGGGTTATTGAGGATGATTTTATTGCTGGCCGCCCGGCACTGGAGAACGTTGGGGCGGAAATGGTCACCTC
GGTTTTGCCTTATGAAGAAGCCAAAATCCGCATTCTGAACGCCAGCCACAGTTGTATTGCTTGGGCGGGCAGCTTGATTG
GGCAATGTTATATTCATGAAAGTACCCAAACCGACGCTATCCGCCAGATGGCTTATGACTATGTCACGCAAGATGTCATT
CCCTCCCTGACGCCCAGCCCACTTGATTTAGCCCATTACCGCGATGTGGTACTGGAACGTTTCAGTAATCCGTATATTCG
CGATACGAACCAGCGTGTCGCCGCCGATGGATTTTCCAAAATCCCCGGATTTATCACTCCCACGCTGATCGAGTGTTACC
AACGTGGCGGAGTGCCTACCGCTACCGCAATGTTGCCCGCATTATTCTTCGTATTTATGGAAAGTTGGCACCAAGGCACT
CTGCCGTATGAATATCAGGATGGTATTCTGGACCCAGCAGCCGTCCATGCCATGTTTCAGTCTTCTGACCCTGCAGGCTT
ATTTGCCCGTGATAGCGCCCTTTTCGGGCCGCTGGCCAATGATGATCAGTTCGAACAGTTATTACGCCAGTCCATAAATC
GTGTCTCTGCTTGGGTTAGCACTAACCGTTAA

Upstream 100 bases:

>100_bases
GGCAAAAGTTACATTAACCTACACGAAAGGGCAAATGCCCAAATATTGAATTTATGCCCAAACAATAACTGTAGCACCTT
CTGTAATTGTGGAGATTATT

Downstream 100 bases:

>100_bases
TCCCTGAGGAGGGGCTTGGGGGGGCGGCGCGTTTAGGGGGCGGGGGATCTCCGGTGATAAATGATCGTCAGTAATTAATG
ATCAGCCGTAATTAACGATC

Product: putative mannitol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRAQHGEYVLETVTPSGERQYEK
ITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYLDNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKS
GPVTLLNCDNLRHNGERFRHGLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
FIQWVIEDDFIAGRPALENVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHESTQTDAIRQMAYDYVTQDVI
PSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSKIPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGT
LPYEYQDGILDPAAVHAMFQSSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR

Sequences:

>Translated_463_residues
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRAQHGEYVLETVTPSGERQYEK
ITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYLDNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKS
GPVTLLNCDNLRHNGERFRHGLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
FIQWVIEDDFIAGRPALENVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHESTQTDAIRQMAYDYVTQDVI
PSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSKIPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGT
LPYEYQDGILDPAAVHAMFQSSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR
>Mature_463_residues
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRAQHGEYVLETVTPSGERQYEK
ITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYLDNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKS
GPVTLLNCDNLRHNGERFRHGLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
FIQWVIEDDFIAGRPALENVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHESTQTDAIRQMAYDYVTQDVI
PSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSKIPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGT
LPYEYQDGILDPAAVHAMFQSSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790779, Length=374, Percent_Identity=34.4919786096257, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788497, Length=356, Percent_Identity=33.1460674157303, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787823, Length=360, Percent_Identity=32.5, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI48994885, Length=414, Percent_Identity=22.2222222222222, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790028, Length=365, Percent_Identity=23.2876712328767, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324401, Length=456, Percent_Identity=32.6754385964912, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6320765, Length=456, Percent_Identity=32.6754385964912, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DALD_YERPE (P58709)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AF0283
- RefSeq:   NP_669323.1
- RefSeq:   NP_993444.1
- RefSeq:   YP_002347292.1
- ProteinModelPortal:   P58709
- GeneID:   1146955
- GeneID:   1175157
- GeneID:   2765378
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2325
- KEGG:   ypk:y2008
- KEGG:   ypm:YP_2112
- HOGENOM:   HBG510279
- OMA:   IARVLPW
- ProtClustDB:   CLSK889158
- BioCyc:   YPES187410:Y2008-MONOMER
- BioCyc:   YPES214092:YPO2325-MONOMER
- BRENDA:   1.1.1.11
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.11

Molecular weight: Translated: 51985; Mature: 51985

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
QHGEYVLETVTPSGERQYEKITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYL
HCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
DNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKSGPVTLLNCDNLRHNGERFRH
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
GLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
HHHHHHHHCCHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
FIQWVIEDDFIAGRPALENVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHE
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEC
STQTDAIRQMAYDYVTQDVIPSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSK
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHCCHHH
IPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGTLPYEYQDGILDPAAVHAMFQ
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
SSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
QHGEYVLETVTPSGERQYEKITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYL
HCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
DNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKSGPVTLLNCDNLRHNGERFRH
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
GLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
HHHHHHHHCCHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
FIQWVIEDDFIAGRPALENVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHE
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEC
STQTDAIRQMAYDYVTQDVIPSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSK
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHCCHHH
IPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGTLPYEYQDGILDPAAVHAMFQ
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
SSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430