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The map label for this gene is fnr [H]

Identifier: 218929392

GI number: 218929392

Start: 2586459

End: 2587211

Strand: Direct

Name: fnr [H]

Synonym: YPO2300

Alternate gene names: 218929392

Gene position: 2586459-2587211 (Clockwise)

Preceding gene: 218929391

Following gene: 218929393

Centisome position: 55.58

GC content: 44.75

Gene sequence:

>753_bases
ATGATCCCTGAAAAACGCGTTATCCGACGAATTCAGTCTGGTGGGTATGCAATTCACTGTCAGGATTGCAGCATCAGTCA
GCTCTGTATTCCGTTTACCTTAAATGAGCATGAGCTTGATCAGCTCGACAATATCATTGAAAGGAAAAAACCTATTCAAA
AAGGACAGGCGCTGTTTAAAGCAGGTGATGAACTTAAATCACTGTATGCTATCCGTTCTGGGACCATTAAAAGCTACACC
ATTACCGAAGAAGGCGATGAACAAATTACCGGTTTCCATCTGGCGGGTGATTTAGTCGGTTTCGATGCGATCAGTAATCT
GCAACACCCAAGTTTTGCCCAAGCGTTAGAAACATCAATGGTGTGTGAAATCCCATTTGATACCTTGGATGATCTTTCCG
GTAAAATGCCCAATCTGCGCCAACAGATAATGCGTTTGATGAGCGGTGAAATCAAAGGCGATCAAGACATGATCTTGCTG
CTCTCTAAAAAGAATGCGGAAGAGCGCCTGGCCGCCTTTATCTACAATCTATCCCATCGTTTTGCTCAGCGCGGTTTCTC
ACCACGTGAATTTCGCTTGACCATGACCCGTGGTGATATTGGTAACTATTTAGGCCTGACAGTGGAAACGATTAGCCGCT
TACTGGGGCGTTTCCAGAAAAGCAATATTCTCAGCGTGAAAGGAAAATACATCACGATTGAGAATAACGAAGCACTGGCT
CAGTTGGCAGGTAACCCAAAACCTCGGCTATAG

Upstream 100 bases:

>100_bases
ACATGAGGGTTATCTTTTAGGTTGCTAATCATTGTTGCTCTTATCAGAAACACTAAAAGATGTTAAAATTGACGCATATC
AATATTAATGGGAATACCCT

Downstream 100 bases:

>100_bases
TTAGATTGTTAGAGACCAGATCAATAAAATGCCTACTTATTGGTCTGGTTATCCCTCTCTCACCTATCCTGTTTCTCTAT
CATGGTTTACTCTTTAACTA

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIPEKRVIRRIQSGGYAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQALFKAGDELKSLYAIRSGTIKSYT
ITEEGDEQITGFHLAGDLVGFDAISNLQHPSFAQALETSMVCEIPFDTLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSHRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSNILSVKGKYITIENNEALA
QLAGNPKPRL

Sequences:

>Translated_250_residues
MIPEKRVIRRIQSGGYAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQALFKAGDELKSLYAIRSGTIKSYT
ITEEGDEQITGFHLAGDLVGFDAISNLQHPSFAQALETSMVCEIPFDTLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSHRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSNILSVKGKYITIENNEALA
QLAGNPKPRL
>Mature_250_residues
MIPEKRVIRRIQSGGYAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQALFKAGDELKSLYAIRSGTIKSYT
ITEEGDEQITGFHLAGDLVGFDAISNLQHPSFAQALETSMVCEIPFDTLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSHRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSNILSVKGKYITIENNEALA
QLAGNPKPRL

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=247, Percent_Identity=92.7125506072875, Blast_Score=474, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28134; Mature: 28134

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEKRVIRRIQSGGYAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQALFK
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEEGDEQITGFHLAGDLVGFDAISNLQHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHE
VCEIPFDTLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSHR
EEECCCHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSNILSVKGKYITIENNEALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCHHHH
QLAGNPKPRL
HHCCCCCCCC
>Mature Secondary Structure
MIPEKRVIRRIQSGGYAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQALFK
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEEGDEQITGFHLAGDLVGFDAISNLQHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHE
VCEIPFDTLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSHR
EEECCCHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSNILSVKGKYITIENNEALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCHHHH
QLAGNPKPRL
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]