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The map label for this gene is fumC

Identifier: 218929356

GI number: 218929356

Start: 2545225

End: 2546622

Strand: Direct

Name: fumC

Synonym: YPO2264

Alternate gene names: 218929356

Gene position: 2545225-2546622 (Clockwise)

Preceding gene: 218929353

Following gene: 218929359

Centisome position: 54.69

GC content: 48.64

Gene sequence:

>1398_bases
ATGGCAACTACCCGCAGTGAAAAGGATTCTATGGGGTCTATCGATGTACCTGCAAACCAATTATGGGGGGCGCAAACTCA
ACGTTCATTGGCGCATTTTCGAATTTCACAAGAAAAAATGCCAACAGAGCTAATTCATGCATTGGCTCTGACCAAACGAG
CGGCAGCTCAAGTGAATATGGACCTAGGCTTGCTGCCAGCCGAGCGTGCAAAAGCGATTATGCGGGCCGCAGATGAAGTT
CTGGATGGCGCTCATCCAACCGAGTTCCCTCTCGCCATCTGGCAAACCGGGTCGGGTACTCAGACGAATATGAATATGAA
TGAGGTACTGGCAAACCGTGCGAGTGAGTTGCTCGGGGGGGCGCGGGGGAATAACCGTTTGGTTCATCCCAATGATGATG
TCAATAAAAGCCAAAGTTCAAATGATGTCTTCCCAACGGCGATGCATGTCGCTGCAGTGATGGGGGTGAGTGAACATCTT
CTTCCTGAACTGAAGGTGTTACAGAAAACCTTGGCCGACAAAGCAGAAGCTTATCGCGATATTGTAAAAATTGGCCGTAC
ACATTTACAAGATGCGACCCCTTTAACGTTGGGGCAGGAAATTTCCGGGTGGGCGGCAATGTTATCTCACAGTGTGCGGC
ATATTGAGGCGACCCTTCCTCACCTGTGTGAATTAGCGCTTGGGGGAACAGCGGTGGGGACTGGCCTCAATACGCATCCT
GAATATGCTGTACGAGTAGCTAATGAAATAGCCACACTGACACGCCAACCGTTTATCACTGCCCCGAATAAATTTGAATC
ATTGGGAACCTGCGATGCATTGGTTCATGGTCACGGTGCGCTAAAAGGCTTAGCGGCATCCCTGATGAAAATTGCCAATG
ATGTCCGTTGGTTATCATCAGGCCCTCGCTGTGGTATTGGCGAAATATCTATTCCGGAAAATGAGCCAGGCAGTTCTATC
ATGCCAGGCAAAGTGAATCCAACACAGTGTGAAGCGATGACCATGCTATGTGCTCAAGTTATGGGTAATGATGTGGCTAT
CAATATCGGTGGGGCGTCCGGCAACTTTGAATTAAACGTGTTCCGTCCATTGGTCATCCATAACTTCCTGCAATCTGTTC
GTTTGTTGGCTGATGGAATGCGTGGTTTTAATGAGCACTGCGCTTTGGGAATTGAACCCAACCGCGACCGTATTACGCAA
TTGCTCAATGAATCGCTGATGTTAGTTACCGCGCTCAATACCCATATTGGCTACGATAAAGCAGCTGAAATCGCCAAAAA
GGCGCATAAAGAGGGGCTAACACTGAAAGCAGCAGCTATGGCATTGGGTTATCTTACCGATGCAGAGTTTGATGAATGGG
TTCGACCGGAAGATATGGTCGGCAGTATGAAGAAATAG

Upstream 100 bases:

>100_bases
TCGCATAAGCGCAATACTATCTGTGTCATTATAACCGCTATGTCGTAAGCCTATGCTAGCTCAACATCAATCTTTTGTTC
TAAATGCTAAGGAGGCAGTG

Downstream 100 bases:

>100_bases
CGGATAAACATTGTTATATTAACGCCGGGGTGGATTACCGGCGTTTTTACAGTGGCTAAGCCGCAATAAATGGCATTTTT
TACGGTTCCAGTTCGACATA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEV
LDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHL
LPELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK

Sequences:

>Translated_465_residues
MATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEV
LDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHL
LPELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
>Mature_464_residues
ATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNMDLGLLPAERAKAIMRAADEVL
DGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGGARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLL
PELKVLQKTLADKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHPE
YAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSIM
PGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNVFRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQL
LNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=60.3485838779956, Blast_Score=554, Evalue=1e-158,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=53.030303030303, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787896, Length=464, Percent_Identity=82.7586206896552, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=459, Percent_Identity=38.3442265795207, Blast_Score=324, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=59.1792656587473, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=61.8461538461539, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=55.6277056277056, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=58.9130434782609, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=58.9130434782609, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=57.1428571428571, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=57.0498915401301, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=50.8658008658009, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_YERPE (Q8ZEB6)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0275
- RefSeq:   NP_669418.1
- RefSeq:   YP_002347231.1
- ProteinModelPortal:   Q8ZEB6
- SMR:   Q8ZEB6
- GeneID:   1147053
- GeneID:   1175095
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2264
- KEGG:   ypk:y2106
- KEGG:   ypm:YP_2061
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BioCyc:   YPES187410:Y2106-MONOMER
- BioCyc:   YPES214092:YPO2264-MONOMER
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 50130; Mature: 49999

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 100-100

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNM
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERAKAIMRAADEVLDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLLPELKVLQKTLADKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHCCHHEEEEHHHHHCCCHH
AAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
ATTRSEKDSMGSIDVPANQLWGAQTQRSLAHFRISQEKMPTELIHALALTKRAAAQVNM
CCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERAKAIMRAADEVLDGAHPTEFPLAIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
ARGNNRLVHPNDDVNKSQSSNDVFPTAMHVAAVMGVSEHLLPELKVLQKTLADKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLSHSVRHIEATLPHLCELALGGTAVGTGLNTHP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EYAVRVANEIATLTRQPFITAPNKFESLGTCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVMGNDVAINIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPLVIHNFLQSVRLLADGMRGFNEHCALGIEPNRDRITQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHCCHHEEEEHHHHHCCCHH
AAEIAKKAHKEGLTLKAAAMALGYLTDAEFDEWVRPEDMVGSMKK
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430