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The map label for this gene is manA [H]

Identifier: 218929355

GI number: 218929355

Start: 2543766

End: 2544941

Strand: Reverse

Name: manA [H]

Synonym: YPO2263

Alternate gene names: 218929355

Gene position: 2544941-2543766 (Counterclockwise)

Preceding gene: 218929357

Following gene: 218929354

Centisome position: 54.69

GC content: 48.38

Gene sequence:

>1176_bases
ATGCTAAAAATGAATAACGCAGTTCAAAACTATGCTTGGGGCAGTACTGATGCCCTGACCCAGCTTTATGGCATACCTAA
CCCACAAGGAATGCCAATGGCTGAACTGTGGATGGGTGCGCACCCGAAAAGCAGTTCCCAGGTTCTTGACGCAAATGGCC
AGTGGCATTCATTACGTGATGTGATTGATCAAGATCCAGATAACACGCTGGGGAGTGATATTTTCAAGCGCTTTGGTGAA
CTGCCATTCCTGTTCAAAGTACTTTGTGCAGCTCAACCTCTATCGATTCAGGTTCACCCGAGCAAAGCGGCAGCAGAGGT
CGGTTTTGCTAAAGAAAACCAGGCAGGTATCCCACTGGATGCGGCTGAGCGCAATTATAAAGATGCGAACCATAAGCCTG
AGCTGGTTTATGCCCTCACCCCTTTTCAGGCAATGAATGGTTTTCGCACACTAGAAGATATCCAGGCGCTGTTACAACCA
CTAGCAGCGGCACACCCTGATATTGCCGCGTTCTTGCGCCAACCCGATACTGAGCATTTAGCCAGTTTATTTGCCAGCTT
ACTCAGTATGAGCGGTGAGACAAAAACGCGGGCACTCGGTATTCTGAAAGCGGCATTGAATAGCCAACTCGGAGAGCCTT
GGGATACGATCCGCAGCATTTCGTGTTTTTATCCCGATGACAGCGGGTTGTTCTCCCCACTACTGCTTAATGCCGTGACA
TTGCAACCGGGTGAGGCCATGTTCCTTTATGCCGAAACACCACACGCTTACCTCAATGGGGTTGCATTAGAGGTCATGGC
AAACTCGGATAATGTGTTGAGAGCTGGGCTAACGCCGAAGTTTATTGATATTCCAGAGTTAATGTCCAATCTGCAATTTA
TCCCTAAACCGGCTAATGCCCTACTCACAACACCAAAGCAACAGGGTAATGAACTGATATTCCCTATTCCTGTCGAGGAC
TTCGCTTTCTCACTGCATACCTTGGTGGTTGAACCACACGTTCTGGCACAACACAGTGCGGCAATTATTTTTTGTGTTGA
AGGCTGTGCGGTGCTGAAAAAACAAGAGCAAGAAATTACGCTGCACCCTGGTGAGTCTTGCTTCATATCGGCTAAGGAAT
CACCTGTAACCGTGCAAGGGGTGGGTTCAATTGCTCGTGTTTATAACGCGGTGTGA

Upstream 100 bases:

>100_bases
ACTAATGGCTTATTTTTTCAGGGTTTGCTATCCAGAACCGGTTAATCACTGGCTAACGCGCAGCCTTATTTTAGTCCTTT
GCAAACGGCAGATCATAAAC

Downstream 100 bases:

>100_bases
ACTAACTTAATGAATTTGTTGCCAATAAATAGCTTCTCACCATAAATTGAAGGCTCTGTCGCGATTAAGTCTTTGTTACG
GTCGCAATAATATTTGTGTA

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGE
LPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQP
LAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNAVT
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED
FAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV

Sequences:

>Translated_391_residues
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGE
LPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQP
LAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNAVT
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED
FAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV
>Mature_391_residues
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGE
LPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQP
LAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNAVT
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED
FAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=409, Percent_Identity=36.4303178484108, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=70.5882352941177, Blast_Score=563, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71997620, Length=405, Percent_Identity=32.0987654320988, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17557650, Length=408, Percent_Identity=28.4313725490196, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320839, Length=434, Percent_Identity=31.5668202764977, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356061, Length=401, Percent_Identity=29.925187032419, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42556; Mature: 42556

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRD
CCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCHHHHHH
VIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLD
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCCC
AAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHL
HHHCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
ASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNAVT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCHHHHHHHEEE
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANA
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCEECHHHHHHCCEECCCCCHH
LLTTPKQQGNELIFPIPVEDFAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEIT
EEECCHHCCCEEEEECCHHHHHHHHHHHEECCHHHHCCCCEEEEEECCHHHHHCCCCEEE
LHPGESCFISAKESPVTVQGVGSIARVYNAV
ECCCCCEEEECCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRD
CCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCHHHHHH
VIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLD
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCCC
AAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHL
HHHCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
ASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNAVT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCHHHHHHHEEE
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANA
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCEECHHHHHHCCEECCCCCHH
LLTTPKQQGNELIFPIPVEDFAFSLHTLVVEPHVLAQHSAAIIFCVEGCAVLKKQEQEIT
EEECCHHCCCEEEEECCHHHHHHHHHHHEECCHHHHCCCCEEEEEECCHHHHHCCCCEEE
LHPGESCFISAKESPVTVQGVGSIARVYNAV
ECCCCCEEEECCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]