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The map label for this gene is rnb [H]

Identifier: 218929332

GI number: 218929332

Start: 2510605

End: 2512539

Strand: Reverse

Name: rnb [H]

Synonym: YPO2235

Alternate gene names: 218929332

Gene position: 2512539-2510605 (Counterclockwise)

Preceding gene: 218929335

Following gene: 218929331

Centisome position: 53.99

GC content: 50.28

Gene sequence:

>1935_bases
ATGTTTCAAGATAACCCGCTGCTGGCGCAGCTAAAACAGCAACTTCACACTCAGACCCCACGCGTTGAAGGCGTCGTTAA
AGGTACTGAGAAAGGCTTTGGCTTTCTTGAGGTAGATGGGCAGAAAAGTTACTTTATTCCGCCTCCGCAGATGAAGAAGG
TCATGCACGGCGATCGCATTATTGCCACCCTGCATACGGATAAGGATCGTGAAATTGCTGAACCTGAAACATTGGTTGAG
CCATTTTTATCCCGCTTTGTTGGCCGGGTGCAACGAAAAGATGATCGTCTGTCTATCGTGCCCGACCACCCTTTATTACG
TGATGCTATTCAATGCCGCCCAGTACGTGAACTGACGCATAGCTTCCAAAACGGTGATTGGGCAGTGGCTGAGATGTGCC
GCCACCCATTAAAAGGCGACCGCGCCTTTCAGGCTGACCTAACCGCGTTTATTACCAATGGTGAAGACCACTTCGTTCCT
TGGTGGGTAACACTGGCTCGCCATAACCTTGAGCGTGAAGCCCCTGCTATGGTCGAATCGGCCTTAAATGACGCCGAGCT
TGAGCGTGAAGACTTAACCGCACTTAATTTTGTCACTATCGACAGCGCCAGCACTGAAGACATGGATGATGCGCTGTTTG
TCCAAGACAATGGCGACGGTTCATGGTTATTGACCATTGCCATTGCAGACCCAACAGCTTACGTCGTCGAAAACAGTGAA
TTGGATTTAACCGCCCGTAAGCGTGCTTTTACCAATTATCTGCCGGGTTTTAACATCCCGATGCTTCCGCGTGATTTGTC
CGACAACCTCTGTTCACTGCGCCCAAATGAACGTCGCCCAGTATTGGTTTGCCGTGTGACGATCACAGAAGAAGGGACGC
TAAGTAACGATATTCGTTTCTCCGCTGCTTGGGTTGAATCAAAAGCCAAACTGGTTTACGACGATGTCTCTGACTGGTTG
GAAGGAAATAATCGCTGGCAGCCACAAGATACCGCTATTGCAGAGCAGATTACGTTACTGAAACGTATCTGTGACGCCCG
TAGCAACTGGCGTCAACAACATGCGCTGGTCTTTAAAGACCGCCCAGACTATCGCTTCCTGTTGGGTGAAAAAGGCGAAG
TGCTGGATATCATTGTTGAGCATCGTCGTATCGCCAACCGCATTGTAGAAGAGTGTATGATTGCGGCGAACGTCTGTGCG
GCATTGGCGTTACGGGAACACCTCGGTTTTGGTATTTATAACGTGCATACCGGTTTTGACCCGGCATTAGTCGAACAAGC
GGCTAGCGTATTGAAAGCCAATGGTGTTGGTGCCGATCCTCAAGCCCTGCTGACGTTACCCGGTTTCTGTGAGTTACGCC
GTCACCTTGATGCCCTGCCAACACAGTTCCTCGACAGCCGTATTCGCCGTTTCCAGACATTTGCTGAAATTAGTACTGTC
CCCGGTCCGCATTTTGGCTTGGGGCTTGAAGCCTATGCCACCTGGACATCTCCAATCCGTAAATACGGCGACATGGTCAA
TCATCGCCTGCTGAAAGCGATGATTACTGGTCAACAAGCAGAAAAACCACAAGAAGAGATCACGGTCCAATTGGCTGAAC
GTCGCCGCCTGAATCGCATGGCTGAACGTGATGTCGGTGATTGGTTGTATGCCCGTTATCTGCAACCACAAGCAGGAACT
GACACTCGTTTCACGGCAGAGATTATTGATATCACCCGCGGTGGCTTGCGTGTGCGTTTACTGGATAACGGTGCCGTTGC
CTTTATTCCTGCGCCGTTTATTCACGCGGTGCGTGATGAAGTGGTCTGCAGCCAGGAAACCGGTACTGTGCAGATCAAAG
GCGAAACAGTTTATAGCCAAAGTGACAAAATCGAGGTACGTATTGCGGAAGTTCGCATGGAAACCCGTAATGTCATTGCT
CGCCCAGTAGCTTAA

Upstream 100 bases:

>100_bases
GAATTGCCATTCCGGATCATATCCACTTGCCCGACGGGGCTGATTCGCGTAAAACTGTCAGCCGGATTAAACCCTCTCAC
TACACCATTCACTGGACGAT

Downstream 100 bases:

>100_bases
TTTTCTTATGTTTTAACATGATAGCCGTCGGAGGAATTCCCCCGACGGCTTTTTTAATGTTATGTTTGCCGCCCTTCTTG
CTTAACGTCGCTGCTGTGTT

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVE
PFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVP
WWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTITEEGTLSNDIRFSAAWVESKAKLVYDDVSDWL
EGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCA
ALALREHLGFGIYNVHTGFDPALVEQAASVLKANGVGADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGT
DTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIA
RPVA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVE
PFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVP
WWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTITEEGTLSNDIRFSAAWVESKAKLVYDDVSDWL
EGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCA
ALALREHLGFGIYNVHTGFDPALVEQAASVLKANGVGADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGT
DTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIA
RPVA
>Mature_644_residues
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVE
PFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVP
WWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTITEEGTLSNDIRFSAAWVESKAKLVYDDVSDWL
EGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCA
ALALREHLGFGIYNVHTGFDPALVEQAASVLKANGVGADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGT
DTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIA
RPVA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI219521928, Length=443, Percent_Identity=23.9277652370203, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI19115966, Length=443, Percent_Identity=23.9277652370203, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI190014623, Length=373, Percent_Identity=25.7372654155496, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI190014625, Length=373, Percent_Identity=25.7372654155496, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI134288890, Length=354, Percent_Identity=27.1186440677966, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=74.3788819875776, Blast_Score=1003, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=661, Percent_Identity=28.1391830559758, Blast_Score=209, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17553506, Length=442, Percent_Identity=26.6968325791855, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI212645896, Length=476, Percent_Identity=25.8403361344538, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24649634, Length=399, Percent_Identity=27.3182957393484, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922976, Length=434, Percent_Identity=26.2672811059908, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24654597, Length=434, Percent_Identity=26.2672811059908, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24654592, Length=434, Percent_Identity=26.2672811059908, Blast_Score=113, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72876; Mature: 72876

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IATLHTDKDREIAEPETLVEPFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTH
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCHHHHHHH
SFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVPWWVTLARHNLEREAPAMVES
HHCCCCCHHHHHHCCCCCCCCCHHCCEEEEEECCCCCEEHHHHHHHHHCCCHHHHHHHHH
ALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
HCCHHHCCHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEECCC
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTITEEGTLSNDIRF
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEEEEEECCCCCCCCCEE
SAAWVESKAKLVYDDVSDWLEGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKD
EEHHHCCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
RPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCAALALREHLGFGIYNVHTGFD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PALVEQAASVLKANGVGADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
HHHHHHHHHHHHCCCCCCCCHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARYLQPQAGTDTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDE
HHHCHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHHHH
VVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIARPVA
HEECCCCCEEEEECCEEECCCCCEEEEEEEHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IATLHTDKDREIAEPETLVEPFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTH
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCHHHHHHH
SFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVPWWVTLARHNLEREAPAMVES
HHCCCCCHHHHHHCCCCCCCCCHHCCEEEEEECCCCCEEHHHHHHHHHCCCHHHHHHHHH
ALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
HCCHHHCCHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEECCC
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRPVLVCRVTITEEGTLSNDIRF
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEEEEEECCCCCCCCCEE
SAAWVESKAKLVYDDVSDWLEGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKD
EEHHHCCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
RPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCAALALREHLGFGIYNVHTGFD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PALVEQAASVLKANGVGADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
HHHHHHHHHHHHCCCCCCCCHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARYLQPQAGTDTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDE
HHHCHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHHHH
VVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIARPVA
HEECCCCCEEEEECCEEECCCCCEEEEEEEHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA