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The map label for this gene is trpC

Identifier: 218929301

GI number: 218929301

Start: 2479570

End: 2480997

Strand: Reverse

Name: trpC

Synonym: YPO2205

Alternate gene names: 218929301

Gene position: 2480997-2479570 (Counterclockwise)

Preceding gene: 218929302

Following gene: 218929300

Centisome position: 53.31

GC content: 50.98

Gene sequence:

>1428_bases
ATGCAGGAAACTGGGGGTTACAAAACCGAGGGTTATAACGTTGGCAGTGACAAAGTTGACAGTGATAAAACCAAAACCGT
GCTCCACCAAATCGTACACGATAAAGAAATTTGGGTTGCCGCGCGGAAACTGCAACAGCCTCTAACCCGCTTCCAAAACG
AAATCACCCAGAGTCAGCGCGATTTTTATCACGCGCTACAAGGCGATAAAACGGTCTTTATTTTGGAATGCAAAAAAGCC
TCACCTTCTAAAGGGGTTATCCGTGACAACTTTAACCCGGCGGAGATTGCCGGTGTTTATAAGCACTATGCGTCGGCTAT
CTCAGTATTAACGGATGAGAAATATTTCCAGGGCAGTTTTGATTTCTTGCCACAAGTCAGTGCCGCCGTCACTCAGCCGG
TATTGTGTAAAGATTTTATTATTGATGCTTATCAGATTCAGCTAGCGCGGTTTTACCACGCTGACGCCATTTTACTGATG
CTGTCGGTCTTGGACGATGAGGCTTACCGCCAATTGGCCGCCGTCGCACACAGCCTGAACATGGGGGTGTTGACCGAAGC
CAGTAACGCCGAAGAATTGGAGCGTGCTATTACCTTGGGTGCCAAAGTTGTTGGCATCAATAACCGCGACCTGCGTGACC
TGTCTATCGATCTGAATCGCACCCGTGAATTGGCACCACGCCTACCAGAAGGTGTCACAATAATCAGTGAATCTGGCATT
AGTCATTATCGTCAGGTCCGTGAATTGAGCCAATTTGCCAACGGTTTCCTGATTGGCAGTGCCCTGATGTCCGAACCCGA
TCTCAACGCGGCCGTCCGCCGGGTGTTACTGGGCGAAAATAAAGTTTGCGGCCTGACACGCGCACAAGATGCCGCCACGG
CTTACCACGCAGGTGCGGTGTACGGCGGGTTGATTTTTGTCGACAGTTCACCCCGGTATGTGGATATCGCCAGCGCCCGT
ACGGTTATCAGTGGTGCGCCGCTAAAGTATGTCGGTGTTTTTCGTCATGCTGAAATAGAAACTGTACGGCAAACGGCTGA
ACAACTCTCACTGGCAGCAGTGCAATTGCATGGGCATGAAGATCAACAGTATATCAATCAACTGCGCAAAGTATTACCTG
CGGATTGCCAGATTTGGAAGGCACTGAGTGTCGGTGACACGATGCCGGAACGCAACTTACAGCAAGTTGAACGCTACGTA
TTGGATCACGGTACGGGTGGCACAGGGCAACGTTTCGACTGGTCATTATTGGCAGATCAAGCACTAGATAATGTCTTGCT
GGCAGGCGGCTTGGGGCCAGATAACTGTGATGTGGCAGCCCAACTAGGCTGTGCCGGGCTGGATGTCAATTCCGGCGTAG
AAAGCGCCCCTGGCATCAAAGACCCCCAACGGATCGCCGCTGTATTCCAGGCATTACGCGTGTACTGA

Upstream 100 bases:

>100_bases
CCAAGAAAACCTGCGCCATAATGCGCAACAGGCATTGGAAATGATTCACAGCGGTCAGGCTTTTGATCGTGTTACTGCTC
TGGCAGCGAGAGGATAAATC

Downstream 100 bases:

>100_bases
TTGACTCTATTTCAAGATTTACTTTATCCCCAAACAAGATTTACTTTATCCCAAAAATAGTTGGCGTCGCAGCTAACACC
ACTGCGGCTTCAAATACCAA

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQRDFYHALQGDKTVFILECKKA
SPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSFDFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLM
LSVLDDEAYRQLAAVAHSLNMGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAVYGGLIFVDSSPRYVDIASAR
TVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHEDQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYV
LDHGTGGTGQRFDWSLLADQALDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY

Sequences:

>Translated_475_residues
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQRDFYHALQGDKTVFILECKKA
SPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSFDFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLM
LSVLDDEAYRQLAAVAHSLNMGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAVYGGLIFVDSSPRYVDIASAR
TVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHEDQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYV
LDHGTGGTGQRFDWSLLADQALDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY
>Mature_475_residues
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQRDFYHALQGDKTVFILECKKA
SPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSFDFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLM
LSVLDDEAYRQLAAVAHSLNMGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAVYGGLIFVDSSPRYVDIASAR
TVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHEDQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYV
LDHGTGGTGQRFDWSLLADQALDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=451, Percent_Identity=72.9490022172949, Blast_Score=666, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=228, Percent_Identity=38.5964912280702, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320210, Length=211, Percent_Identity=33.6492890995261, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_YERPE (Q8ZEG8)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AG0268
- RefSeq:   NP_669363.1
- RefSeq:   NP_993342.1
- RefSeq:   YP_002347176.1
- ProteinModelPortal:   Q8ZEG8
- SMR:   Q8ZEG8
- IntAct:   Q8ZEG8
- GeneID:   1146996
- GeneID:   1175038
- GeneID:   2765813
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2205
- KEGG:   ypk:y2049
- KEGG:   ypm:YP_2003
- HOGENOM:   HBG296890
- OMA:   YILECKK
- ProtClustDB:   PRK09427
- BioCyc:   YPES187410:Y2049-MONOMER
- BioCyc:   YPES214092:YPO2205-MONOMER
- BRENDA:   4.1.1.48
- BRENDA:   5.3.1.24
- HAMAP:   MF_00134_B
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48; =5.3.1.24

Molecular weight: Translated: 52118; Mature: 52118

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DFYHALQGDKTVFILECKKASPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSF
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCC
DFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLMLSVLDDEAYRQLAAVAHSLN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
MGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
CCEEECCCCHHHHHHHHHHCCEEEECCCCCCCEEEECHHHHHHHHCCCCCCEEEEECCCH
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAV
HHHHHHHHHHHHHCCEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGGLIFVDSSPRYVDIASARTVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHE
CCCEEEECCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
DQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYVLDHGTGGTGQRFDWSLLADQ
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
ALDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY
HHHHEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DFYHALQGDKTVFILECKKASPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSF
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCC
DFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLMLSVLDDEAYRQLAAVAHSLN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
MGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
CCEEECCCCHHHHHHHHHHCCEEEECCCCCCCEEEECHHHHHHHHCCCCCCEEEEECCCH
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAV
HHHHHHHHHHHHHCCEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGGLIFVDSSPRYVDIASARTVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHE
CCCEEEECCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
DQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYVLDHGTGGTGQRFDWSLLADQ
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
ALDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY
HHHHEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430