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The map label for this gene is nhaB [H]

Identifier: 218929245

GI number: 218929245

Start: 2410561

End: 2412135

Strand: Reverse

Name: nhaB [H]

Synonym: YPO2142

Alternate gene names: 218929245

Gene position: 2412135-2410561 (Counterclockwise)

Preceding gene: 218929247

Following gene: 218929244

Centisome position: 51.83

GC content: 46.54

Gene sequence:

>1575_bases
ATGGACATTACCAACAGACAAGCTGTACTCAAGAATTTTCTTGGTAACTCTCCGGATTGGTACAAACTAGCAATTATGGG
GTTCTTGATCATTAACCCTCTAGTCTTCTTCTTTGTCAGCCCCTTTGTCGCGGGCTGGATGCTGGTTATCGAGTTTATCT
TTACCTTAGCCATGGCGCTGAAATGTTACCCGCTGCAACCGGGGGGTTTGCTCGCTATTCAAGCCGTTGCCATCGGCATG
ACCAGCCCGCATCAAGTTGCAGAAGAGATCGCCAATAACCTGGAAGTCCTCTTGCTTTTAGTATTTATGGTGGCCGGCAT
CTACTTTATGAAACAGCTGCTGCTGTTTGTATTTACGAAATTGCTGTTGAATATTCGGTCAAAAACTATCCTTTCCCTGG
CCTTTTGTCTGGCGTCAGCCTTCCTATCAGCATTTTTGGATGCCTTAACCGTAATCGCGGTAGTTATCAGCGTATCCGTT
GGTTTTTATACTATTTATCATAACGTTACTTCAAATCACAGTGACAAAGATATTACTGATGACAGCGGAATCGATAATCA
GGACAGCCATGAAACATTAGAGCAATTCCGGGCATTTTTACGCAGTCTGATGATGCATGCTGGCGTGGGTACCGCTCTGG
GGGGCGTCATGACAATGGTTGGTGAGCCTCAGAATTTGATTATTGCCAAAAGCGCGGGTTGGAATTTTGCTGACTTCTTT
ATTCGCATGTTACCCGTCACCTTACCCGTCTTTATTTTCGGGTTATTGGTCTGCTTGCTGGTCGAAAAATTTAAACTGTT
TGGTTATGGTGCCCAGTTGCCAGAACGTGTGCGTCAGGTTCTGACCGAATACGATCAGCAAGCCAATGCGAAACGGACCA
AGCAAGAGAAGATGAAGTTAATAGTACAAGCCATTATTGGTGTCTGGTTGGTATTGGCACTGGCACTCCATTTAGCTGAA
GTCGGTTTGGTCGGGCTATCCGTTATTATTCTCGCCACCTCATTTTGTGGTATCACAAATGAGCATTCATTGGGCAAAGC
CTTTCAGGAAGCCTTGCCGTTTACCGCGCTGCTAACCGTATTTTTTGCCGTGGTCGCGGTTATTATTGAACAAAGCCTCT
TTACCCCCATTATTCAGTTTGTTTTACAAGCCTCGCCTTCCGCTCAGCTATCGCTGTTTTATCTGTTTAATGGCTTGCTC
TCATCGGTGTCAGACAATGTTTTTGTCGGTACCGTGTATATCAATGAGGCCCGTTCTGCGTTTGAGCATGGTATTGTCTC
GTTACAACAATTTGAATTGTTGGCGGTCGCCATCAATACAGGGACCAACCTCCCCTCCGTGGCGACACCAAACGGCCAGG
CCGCTTTCTTGTTCCTGCTGACTTCGGCATTGGCACCACTAATTCGCCTTTCCTATGGGCGAATGGTATATATGGCTTTG
CCTTATACTCTAGTGATGACGATTGTTGGCCTGCTGGGTGTCGAGTTTTTATTGGTACCGATGACAGAGTGGCTGACTCA
GGCTGGATGGATCAGTTTGCCACACATCACAAACGGGGTTGCCATCCCACACTGA

Upstream 100 bases:

>100_bases
CAGAGAATACGTATTGCTTTTAGCTGGATTACGTAAACTAAAATGTAACCTTTCGTCGTAATCGCATCATAATAATTTAT
TAAGGGAAAAATCATTCACA

Downstream 100 bases:

>100_bases
TCACTTGCATTATGGTTGGCCAGCCTTGGGGATAAGTGCGACAACTCAAGGTGGCACGAATGGGGGCTGGCAAAACCAAC
CAACATCTCACCCAAAGTAA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQANAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH

Sequences:

>Translated_524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQANAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH
>Mature_524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQANAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=513, Percent_Identity=75.6335282651072, Blast_Score=753, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 57477; Mature: 57477

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA