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The map label for this gene is pip [H]

Identifier: 218928903

GI number: 218928903

Start: 2028321

End: 2029271

Strand: Direct

Name: pip [H]

Synonym: YPO1781

Alternate gene names: 218928903

Gene position: 2028321-2029271 (Clockwise)

Preceding gene: 218928902

Following gene: 218928905

Centisome position: 43.58

GC content: 49.11

Gene sequence:

>951_bases
ATGGAACAATTACGTGGACTTTATCCTGCATATGAACCTTACGACAGCGGTTTATTAGACACCGGGGACGGGCATCAAAT
TTATTGGGAGCTCTGCGGCAATCCGAAGGGCAAGCCCGCGATCTTTATTCACGGGGGGCCAGGGGGCGGGATTGCACCTT
ATCATCGGCAGCTATTCAACCCTGCAAAATATAATGTGATGTTATTTGATCAACGTGGCTGTGGGCGCTCTAAACCCCAT
GCCAGCTTGGATAACAACACGACTTGGCATCTGGTGGAGGATATTGAACGTCTGCGCAAGATGGCCGGGATTGAACAATG
GCTGGTGTTTGGCGGTTCTTGGGGATCGACTCTGGCATTGGCTTATGGCGAAACACACCCTGAACGTGTCAGTGAGATGG
TTCTGCGTGGGATCTTCACTTTACGCAGGAAAGAACTGCATTGGTACTATCAAGAGGGGGCCTCGCGCTTTTTCCCCGAG
AAATGGCAGCGGGTACTGTCAATTTTATCCCCAGAAGAGCAGGGCGATGTGATAGCGGCTTATCGTAAACGGCTGACATC
ACCTGATCGGGCAATACAGCTAGAGGCCGCTAAAATATGGAGTTTGTGGGAAGGCGAAACAGTGACCTTATTACCAACTA
AAAGCTCGGCTTCCTTTGGTGAAGAGCATTTTGCACTGGCGTTTGCCCGGATTGAAAATCACTATTTCACGCATCTTGGC
TTCTTGGACAGTGATAACCAGTTGTTAGACAATGTGACACGTATACGGCATATCCCAGCTGTAATTATTCATGGTCGATA
TGATATGGCGTGTCAGCTACAGAACGCCTGGGATTTAGCACAGGCTTGGCCTGAAGCTGAGCTCTATATCGTTGAAGGTG
CCGGGCACTCCTTTGATGAGCCAGGGATACTGCATCAACTTATTCTAGCTACTGATAAATTTGCTCACTGA

Upstream 100 bases:

>100_bases
ATTAAATGGGTGACTGGCATGAATCTGAGGTTTTGTCATTGACCCTGCGGGCGGTATAGGTTTTGATAACTTAATATCTA
ATAACAAGCATGGAAAAATA

Downstream 100 bases:

>100_bases
CTCTACGCATTTAAGGCGACTGACTCCCGCGGGTTAAGGCCTACGGGAGCATTTCACGATTACTTCACTTTAGGTTCATA
CGGCAGTCGAGATAATTTTT

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MEQLRGLYPAYEPYDSGLLDTGDGHQIYWELCGNPKGKPAIFIHGGPGGGIAPYHRQLFNPAKYNVMLFDQRGCGRSKPH
ASLDNNTTWHLVEDIERLRKMAGIEQWLVFGGSWGSTLALAYGETHPERVSEMVLRGIFTLRRKELHWYYQEGASRFFPE
KWQRVLSILSPEEQGDVIAAYRKRLTSPDRAIQLEAAKIWSLWEGETVTLLPTKSSASFGEEHFALAFARIENHYFTHLG
FLDSDNQLLDNVTRIRHIPAVIIHGRYDMACQLQNAWDLAQAWPEAELYIVEGAGHSFDEPGILHQLILATDKFAH

Sequences:

>Translated_316_residues
MEQLRGLYPAYEPYDSGLLDTGDGHQIYWELCGNPKGKPAIFIHGGPGGGIAPYHRQLFNPAKYNVMLFDQRGCGRSKPH
ASLDNNTTWHLVEDIERLRKMAGIEQWLVFGGSWGSTLALAYGETHPERVSEMVLRGIFTLRRKELHWYYQEGASRFFPE
KWQRVLSILSPEEQGDVIAAYRKRLTSPDRAIQLEAAKIWSLWEGETVTLLPTKSSASFGEEHFALAFARIENHYFTHLG
FLDSDNQLLDNVTRIRHIPAVIIHGRYDMACQLQNAWDLAQAWPEAELYIVEGAGHSFDEPGILHQLILATDKFAH
>Mature_316_residues
MEQLRGLYPAYEPYDSGLLDTGDGHQIYWELCGNPKGKPAIFIHGGPGGGIAPYHRQLFNPAKYNVMLFDQRGCGRSKPH
ASLDNNTTWHLVEDIERLRKMAGIEQWLVFGGSWGSTLALAYGETHPERVSEMVLRGIFTLRRKELHWYYQEGASRFFPE
KWQRVLSILSPEEQGDVIAAYRKRLTSPDRAIQLEAAKIWSLWEGETVTLLPTKSSASFGEEHFALAFARIENHYFTHLG
FLDSDNQLLDNVTRIRHIPAVIIHGRYDMACQLQNAWDLAQAWPEAELYIVEGAGHSFDEPGILHQLILATDKFAH

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35974; Mature: 35974

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLRGLYPAYEPYDSGLLDTGDGHQIYWELCGNPKGKPAIFIHGGPGGGIAPYHRQLFN
CCCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHCC
PAKYNVMLFDQRGCGRSKPHASLDNNTTWHLVEDIERLRKMAGIEQWLVFGGSWGSTLAL
CCCEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHEEEEECCCCCCEEEE
AYGETHPERVSEMVLRGIFTLRRKELHWYYQEGASRFFPEKWQRVLSILSPEEQGDVIAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHH
YRKRLTSPDRAIQLEAAKIWSLWEGETVTLLPTKSSASFGEEHFALAFARIENHYFTHLG
HHHHCCCCCCEEEEEHHHHEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEE
FLDSDNQLLDNVTRIRHIPAVIIHGRYDMACQLQNAWDLAQAWPEAELYIVEGAGHSFDE
EECCCHHHHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCC
PGILHQLILATDKFAH
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEQLRGLYPAYEPYDSGLLDTGDGHQIYWELCGNPKGKPAIFIHGGPGGGIAPYHRQLFN
CCCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHCC
PAKYNVMLFDQRGCGRSKPHASLDNNTTWHLVEDIERLRKMAGIEQWLVFGGSWGSTLAL
CCCEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHEEEEECCCCCCEEEE
AYGETHPERVSEMVLRGIFTLRRKELHWYYQEGASRFFPEKWQRVLSILSPEEQGDVIAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHH
YRKRLTSPDRAIQLEAAKIWSLWEGETVTLLPTKSSASFGEEHFALAFARIENHYFTHLG
HHHHCCCCCCEEEEEHHHHEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEE
FLDSDNQLLDNVTRIRHIPAVIIHGRYDMACQLQNAWDLAQAWPEAELYIVEGAGHSFDE
EECCCHHHHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCC
PGILHQLILATDKFAH
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]