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The map label for this gene is lolE [H]

Identifier: 218928764

GI number: 218928764

Start: 1852385

End: 1853635

Strand: Direct

Name: lolE [H]

Synonym: YPO1628

Alternate gene names: 218928764

Gene position: 1852385-1853635 (Clockwise)

Preceding gene: 218928763

Following gene: 218928765

Centisome position: 39.8

GC content: 49.0

Gene sequence:

>1251_bases
GTGATGGGGGTTTCGCCACTTTCACTTCTTATCGGTTTACGGTTTAGCCGTGGTCGCCGTCGTGGCGGTATGGTGTCGTT
AATCTCCGTGATTTCTACGCTAGGTATCGCCTTGGGTGTGGCAGTGCTTATCGTGGGGTTAAGTGCGATGAACGGCTTCG
AACGTGAGCTGAAAAATCGTATTTTAGCCGTGGTGCCTCACGGCGAAATTGCCGTGGTTAATCAGCCGTTCAGCGGTTGG
CCACAAACCTTACAGCGTATCGAAAAGGTGCCCGGTATCGTGGCTGCTGCGCCTTATATTAATTTTACTGGTTTGATTGA
AAACAGTACGCAACTGCGGGCAGTGCAGGTCAAAGGTGTGGATCCCGAGGCCGAACAGCATCTCAGTGCGTTGCCTAGCT
TCGTTCTTGACAATGCCTGGAGCCATTTTAAGGCCGGGCAACAACAGATTATTTTAGGTAAAGGATTGGCTGATACCTTG
GGGGTGAAGCAAGGTGATTGGTTGACGGTGATGATCCCCAACAGCGATCCTGAGATGAAATTGCTGCAACCTAAGCGCAT
CCGTTTACAGGTTGCCGGTATTTTTCAACTGAGTGGTCAGTTGGATCACAGTTTGGCATTAGTGCCTCTAATCGATGCAC
AACAATATCTTGATATGGGTGATAGTGTCACGGGTATCGCCATCAAAGTGAATGATGTTTACAACGCCAATCAACTGGTA
CGTAACGCGGGTGAAGTGAGTAACGCATACGTTTATATCAGTAGCTGGATTGGGACCTATGGCTATATGTACCGTGATAT
CCAAATGATCCGCACTATCATGTATTTAGCGATGGTACTCGTGATCGGCGTCGCCAGTTTTAATATTGTGTCAACGTTGG
TCATGGCGGTTAAAGATAAAAGTAGCGATATCGCAGTATTACGTACATTAGGTGCCAAAGATGGTCTGATTCGCGCCATC
TTCATTTGGTATGGCCTGTTGGCTGGCCTTATTGGCAGTATCAGCGGGGCCGTGATAGGGGTTATCGTCTCCCTACAGTT
GACCACCATAATCCGCGGGCTAGAAAAGATGGTCGGGCATCAATTTTTGTCGAGCGATATCTATTTCATTGATTTTCTAC
CGTCAGAGTTGCGTTGGTTTGATGTGGCTTGTGTGTTGGCAACGGCACTGGTGCTCAGCTTGATTGCCAGTTGGTATCCG
GCACGTCGCGCCAGTCGTATTGATCCGGCACGGGTCCTCAGCGGGCAGTAA

Upstream 100 bases:

>100_bases
TGGTGGTGACTCACGATTTACAATTAGCGAAACGGATGAGCCGTCAACTTGAAATGCGAGATGGTCAGCTACAACACCAT
TTGACGCTGGTGGGGGCCGA

Downstream 100 bases:

>100_bases
TTGAAGAAAGGCAGGCTTATGTATTACGGTTTTGATATGGGCGGGACCAAAATAGAGCTAGGCGTTTTTGATGAAAACCT
GCAGCGAATATGGCATAAGC

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MMGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIAVVNQPFSGW
PQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVDPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTL
GVKQGDWLTVMIPNSDPEMKLLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLV
RNAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKSSDIAVLRTLGAKDGLIRAI
FIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQFLSSDIYFIDFLPSELRWFDVACVLATALVLSLIASWYP
ARRASRIDPARVLSGQ

Sequences:

>Translated_416_residues
MMGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIAVVNQPFSGW
PQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVDPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTL
GVKQGDWLTVMIPNSDPEMKLLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLV
RNAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKSSDIAVLRTLGAKDGLIRAI
FIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQFLSSDIYFIDFLPSELRWFDVACVLATALVLSLIASWYP
ARRASRIDPARVLSGQ
>Mature_416_residues
MMGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIAVVNQPFSGW
PQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVDPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTL
GVKQGDWLTVMIPNSDPEMKLLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLV
RNAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKSSDIAVLRTLGAKDGLIRAI
FIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQFLSSDIYFIDFLPSELRWFDVACVLATALVLSLIASWYP
ARRASRIDPARVLSGQ

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=411, Percent_Identity=79.5620437956204, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=27.6029055690073, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45234; Mature: 45234

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNR
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
ILAVVPHGEIAVVNQPFSGWPQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGV
EEEEECCCCEEEECCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEEEEEEECC
DPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLGVKQGDWLTVMIPNSDPEMK
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCE
LLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLV
ECCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHHHCCCCCCEEEEEEEECCCCHHHHH
RNAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDK
HHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSDIAVLRTLGAKDGLIRAIFIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGH
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFLSSDIYFIDFLPSELRWFDVACVLATALVLSLIASWYPARRASRIDPARVLSGQ
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MMGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNR
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
ILAVVPHGEIAVVNQPFSGWPQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGV
EEEEECCCCEEEECCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEEEEEEECC
DPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLGVKQGDWLTVMIPNSDPEMK
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCE
LLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLV
ECCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHHHCCCCCCEEEEEEEECCCCHHHHH
RNAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDK
HHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSDIAVLRTLGAKDGLIRAIFIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGH
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFLSSDIYFIDFLPSELRWFDVACVLATALVLSLIASWYPARRASRIDPARVLSGQ
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]