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The map label for this gene is pncB

Identifier: 218928561

GI number: 218928561

Start: 1602424

End: 1603629

Strand: Reverse

Name: pncB

Synonym: YPO1413

Alternate gene names: 218928561

Gene position: 1603629-1602424 (Counterclockwise)

Preceding gene: 218928565

Following gene: 218928560

Centisome position: 34.46

GC content: 47.26

Gene sequence:

>1206_bases
ATGACTCAAGACGCCTCACCGATTTTGACTTCATTGCTTGATACGGACGCATATAAGCTTCATATGCAACAAGCCGTATT
TCATCATTATCGTCACATTACTGTTGCCGCCGAATTCCGCTGCCGTAGTGATGAGCTGCTGGGGGTGTATGCTGATGAAA
TCCGCCACCAGGTAACCCTGATGGGTCAATTAGCACTGACATCTGATGAGTTTATTTACCTCTCCAGTCTCCCCTTCTTC
CAGGATGATTATCTGCATTGGTTGCGCGATTTTCGTTTTAAACCAGAGCAAGTCTCCGTCGCTGTTCATGACGGTAAATT
AGATATTCGCATTGCCGGTTTATGGTGTGAGGTGATCATGTGGGAAGTGCCTTTGCTGGCAGTGATCAGCGAAATCGTTC
ACCGCCGCCGCTCTACCCAAGTGACAACGGATCAAGCGGTTCAACAACTGCGCACAAAACTTGAGCAATTCAATGCCCTC
AGTGCGGATATCGATATTACTCACTTTAAATTGATGGATTTCGGTACCCGCCGCCGATTCTCTCGCGAGATACAGCACAC
CGTTGTCAGCACGTTAAAAGATGAGTTCCCTTATCTGGTCGGCACCAGCAACTACGACTTAGCCCGCACATTAGCCTTAG
CGCCCGTCGGGACTCAAGCCCATGAGTGGTTTCAGGCTCACCAACAAATTAGCCCAACATTGGCAAACAGCCAGCGTGTA
GCACTGCAAGTCTGGCTGGATGAATACCCCAATCAACTGGGCATCGCACTAACTGATTGCATTACTATGGATGCTTTCCT
ACGCGATTTTGATCTGGCTTTCGCCAACCGCTATCAAGGCCTACGCCATGACTCTGGTGACCCGATCGAGTGGGGGGAGA
AGGCTATCGCGCATTATGAAAAATTGGGTATTGACCCAATGAAAAAGGTATTGGTGTTTTCAGATAATCTAGATCTGGAG
AAAGCATTATTCCTCTACCGTCACTTTTATCAGCGCATTAAGTTGGTGTTTGGTATCGGTACCCGTTTGACCTGCGATAT
ACCAGATGTTAAGCCATTGAATATTGTTATTAAACTGGTTGAATGTAACGATAAACCGGTGGCTAAGCTCTCAGATAGCC
CGGGTAAGACTATTTGTCAGGACCCCGCATTCGTTGATCAATTACGTAAAGCCTTTGCGCTACCGTTAGTCAAGAAAGCC
AGTTAA

Upstream 100 bases:

>100_bases
TGATGAGGCTTCAATAACATGATAATACCGGTATACTCCTGCAACTTTATAGATTTTGCCGACTGTGGAAAATGCTCCTA
CGAGGATGCTGTATAGCGCC

Downstream 100 bases:

>100_bases
TCCCCCCGTTGCCGGGTAGCGTATGTTTACCCGGTAACCCCAACACTGATATTTTTTAGCCTCTCTGTTCTTCCACAATT
AAATTTTCTACTATTACTAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLSSLPFF
QDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNAL
SADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLANSQRV
ALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSDNLDLE
KALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKA
S

Sequences:

>Translated_401_residues
MTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLSSLPFF
QDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNAL
SADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLANSQRV
ALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSDNLDLE
KALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKA
S
>Mature_400_residues
TQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLSSLPFFQ
DDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALS
ADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLANSQRVA
LQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSDNLDLEK
ALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=401, Percent_Identity=73.5660847880299, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6324783, Length=425, Percent_Identity=31.5294117647059, Blast_Score=200, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_YERP3 (A7FJU4)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401522.1
- ProteinModelPortal:   A7FJU4
- SMR:   A7FJU4
- STRING:   A7FJU4
- GeneID:   5386510
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2557
- eggNOG:   COG1488
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- ProtClustDB:   PRK05321
- BioCyc:   YPSE349747:YPSIP31758_2557-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 46022; Mature: 45891

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTL
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIM
HHHEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEEEEHHHHHHHH
WEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADIDITHFKLMDFGTRRRF
HHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHH
SREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLANSQRV
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHEECCCCCHHHHHHHHHHHCCCHHCCCCEE
ALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYE
EEEEEEHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
KLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLV
HHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEE
ECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIM
HHHEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEEEEHHHHHHHH
WEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADIDITHFKLMDFGTRRRF
HHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHH
SREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLANSQRV
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHEECCCCCHHHHHHHHHHHCCCHHCCCCEE
ALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYE
EEEEEEHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
KLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLV
HHCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEE
ECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA