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The map label for this gene is irgA [H]

Identifier: 218928463

GI number: 218928463

Start: 1476003

End: 1478000

Strand: Direct

Name: irgA [H]

Synonym: YPO1313

Alternate gene names: 218928463

Gene position: 1476003-1478000 (Clockwise)

Preceding gene: 218928462

Following gene: 218928466

Centisome position: 31.72

GC content: 46.1

Gene sequence:

>1998_bases
GTGGCTAAGGTTAACCAACGTTTTAGAAAAACACATTCAGCGGCATTAGTTATAGCGGCGGTTATTTCATCGCAAGGGTA
TGCGGCTGAAAAAACAAATACAGCCACACCAACCGATACAATGGTGGTCACTGCGTCAGGTTTCCAGCAGCGTATTCAGG
ATTCTGCGGCCTCAATTTCCGTGGTCACCCGCGAGCAGATTGAAAATAAAGCTTATCGTGATGTCACGGATGCGTTGAAA
GATGTTCCCGGTGTTGTGATTACCGGAGGGGGCAGTACAAGCGATATCAGCATCCGTGGTATGGCGGCGAAATACACCCT
GATTCTGGTCAATGGCAAACGTGTTGATACCCGCAGTACCAGGCCAAACAGCGATGGCTCTGGGATTGAACAAGGTTGGT
TGCCCCCTCTGGCGGCCATTGATCGTATTGAGGTGGTCCGTGGGCCAATGTCCTCTTTATATGGTTCGGACGCCATGGGC
GGTGTGATTAACATCATTACCCGCAAAGTGGGTAAAGAGTGGCATGGCACGGTACGTGCGGATGCGACCTTACAGGAGGA
CAGCAAGTCCGGGGATATATTCCAGACCAATGCTTACGCCTCAGGTCCTTTAATTGACGGTTTATTGGGCCTTAAAGTCA
GCGGTCTACTTTCTCATCGTAGTGAAGATAAAATTATCGATGGTTATAATCAACAGCGCATGAGAAATGGTACGGCAACA
TTTACTCTGACGCCTGACGATAATAATGAATTTGATTTTGACATTGGCCATTATGTACAAGATAGAAATTCAACCCCAGG
ACGAACACTGGCATTAAACGGAACGAATAGTGACACCCAATATGACCGTAATAATTATGCGGTTACTCATAATGGTTATT
ATGATTTTGGTAATTCAACCAGTTATATTCAGCGTGATGAAACCCGTAATCCATCCCGTCAAATGAAAAGTGTGGATAAT
ATCTTCAATACCCAAACATCCTTCTTATTAGATAACCACACTTTAATTCTGGGGGGGCAATACCGTTATGAAGAACTGTA
TGATAAAGGTAACCAATTACCTTCTGCCAGTGATCTGAAGAAATTAACCCGTTGGAGCTGGGCATTATTTGCTGAAGATG
AATGGCAGATGACCAACGATTTCGCGCTAACTGGCGGCATTCGTATGGATCAAGATCAAAACTACGGTACCCATTGGACG
CCACGTTTATACGGAGTCTGGCATTTAGCGGACCAATGGACATTAAAAGGCGGGGTATCCGGCGGTTACCGTTCACCTGA
TTTACGTCAGGCAACCGATGACTGGGGCCAGCTCTCTGGTGGGGGAAAAGGCGGGCTTCCCGCACTTATTCTGGGTAATT
CTAACTTGAAACCCGAGCGCAGCATTAGCCAGGAAATTGGCATACTGTGGGACGATCAGGAAGGGATGAACGCCAGCGTG
ACGCTGTTCTATACCGACTTCAAAGATAAAATTACTGAAGTACGCAACTGTGATATCACCACAAATACGACTGGGCAGTG
TGTATTTAATGGTATCAATTATAAATTCATCAGTGATCGTATTAACGTTGATAAAGCCATGACTCGTGGGGCAGAAGCGA
CCTTTGCTTGGGATATCAATCAAGCCTGGTCGTTAGCCACTAACTATACCTTTACCCAATCTGAGCAGAAGAGCGGGGCA
TTTGCCGGCCAGCCATTAAACCAGATGCCTAAGCATATGCTGAATGGGACGTTAAACTGGAAAACTACCGAAGATTTTGC
AACCTGGATCCGAGCCAATTACCGTGGCAAGGCTTCTGAATATCTTAATCGTACCAGTATGGGCAGCCGTACTCCGTCAT
ATACTTTTGTCGATTTAGGGGCAAATTATCAGCTGACAAAAGAAGTGCGTCTGATGGGCGGTGTTTACAACCTGTTGGAT
AAGCGTGTGGATATTGACGTTAACGATAAGGTGTTGGATGGTCGTCGGTATATGGTGGGTGCCAGCTACGATTTTTAA

Upstream 100 bases:

>100_bases
ACAAATGATATTTCTCACCTGCCCGTCAGGCGGTGTTTTCGCGAGAAAAATAACCTGATGAAAAGGAGTGAATTAATTTA
CACCTCATGGGGATTATAGA

Downstream 100 bases:

>100_bases
CCGCCTCTCCCCTTCGTCCTTGAAGTTGCAGGGGTGTTAGCTGCGCGCACTTACCCGAATCACTTACTTGAGTAAGCTCA
TCGGGATGCGTTTGCTTGCT

Product: putative outer membrane receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MAKVNQRFRKTHSAALVIAAVISSQGYAAEKTNTATPTDTMVVTASGFQQRIQDSAASISVVTREQIENKAYRDVTDALK
DVPGVVITGGGSTSDISIRGMAAKYTLILVNGKRVDTRSTRPNSDGSGIEQGWLPPLAAIDRIEVVRGPMSSLYGSDAMG
GVINIITRKVGKEWHGTVRADATLQEDSKSGDIFQTNAYASGPLIDGLLGLKVSGLLSHRSEDKIIDGYNQQRMRNGTAT
FTLTPDDNNEFDFDIGHYVQDRNSTPGRTLALNGTNSDTQYDRNNYAVTHNGYYDFGNSTSYIQRDETRNPSRQMKSVDN
IFNTQTSFLLDNHTLILGGQYRYEELYDKGNQLPSASDLKKLTRWSWALFAEDEWQMTNDFALTGGIRMDQDQNYGTHWT
PRLYGVWHLADQWTLKGGVSGGYRSPDLRQATDDWGQLSGGGKGGLPALILGNSNLKPERSISQEIGILWDDQEGMNASV
TLFYTDFKDKITEVRNCDITTNTTGQCVFNGINYKFISDRINVDKAMTRGAEATFAWDINQAWSLATNYTFTQSEQKSGA
FAGQPLNQMPKHMLNGTLNWKTTEDFATWIRANYRGKASEYLNRTSMGSRTPSYTFVDLGANYQLTKEVRLMGGVYNLLD
KRVDIDVNDKVLDGRRYMVGASYDF

Sequences:

>Translated_665_residues
MAKVNQRFRKTHSAALVIAAVISSQGYAAEKTNTATPTDTMVVTASGFQQRIQDSAASISVVTREQIENKAYRDVTDALK
DVPGVVITGGGSTSDISIRGMAAKYTLILVNGKRVDTRSTRPNSDGSGIEQGWLPPLAAIDRIEVVRGPMSSLYGSDAMG
GVINIITRKVGKEWHGTVRADATLQEDSKSGDIFQTNAYASGPLIDGLLGLKVSGLLSHRSEDKIIDGYNQQRMRNGTAT
FTLTPDDNNEFDFDIGHYVQDRNSTPGRTLALNGTNSDTQYDRNNYAVTHNGYYDFGNSTSYIQRDETRNPSRQMKSVDN
IFNTQTSFLLDNHTLILGGQYRYEELYDKGNQLPSASDLKKLTRWSWALFAEDEWQMTNDFALTGGIRMDQDQNYGTHWT
PRLYGVWHLADQWTLKGGVSGGYRSPDLRQATDDWGQLSGGGKGGLPALILGNSNLKPERSISQEIGILWDDQEGMNASV
TLFYTDFKDKITEVRNCDITTNTTGQCVFNGINYKFISDRINVDKAMTRGAEATFAWDINQAWSLATNYTFTQSEQKSGA
FAGQPLNQMPKHMLNGTLNWKTTEDFATWIRANYRGKASEYLNRTSMGSRTPSYTFVDLGANYQLTKEVRLMGGVYNLLD
KRVDIDVNDKVLDGRRYMVGASYDF
>Mature_664_residues
AKVNQRFRKTHSAALVIAAVISSQGYAAEKTNTATPTDTMVVTASGFQQRIQDSAASISVVTREQIENKAYRDVTDALKD
VPGVVITGGGSTSDISIRGMAAKYTLILVNGKRVDTRSTRPNSDGSGIEQGWLPPLAAIDRIEVVRGPMSSLYGSDAMGG
VINIITRKVGKEWHGTVRADATLQEDSKSGDIFQTNAYASGPLIDGLLGLKVSGLLSHRSEDKIIDGYNQQRMRNGTATF
TLTPDDNNEFDFDIGHYVQDRNSTPGRTLALNGTNSDTQYDRNNYAVTHNGYYDFGNSTSYIQRDETRNPSRQMKSVDNI
FNTQTSFLLDNHTLILGGQYRYEELYDKGNQLPSASDLKKLTRWSWALFAEDEWQMTNDFALTGGIRMDQDQNYGTHWTP
RLYGVWHLADQWTLKGGVSGGYRSPDLRQATDDWGQLSGGGKGGLPALILGNSNLKPERSISQEIGILWDDQEGMNASVT
LFYTDFKDKITEVRNCDITTNTTGQCVFNGINYKFISDRINVDKAMTRGAEATFAWDINQAWSLATNYTFTQSEQKSGAF
AGQPLNQMPKHMLNGTLNWKTTEDFATWIRANYRGKASEYLNRTSMGSRTPSYTFVDLGANYQLTKEVRLMGGVYNLLDK
RVDIDVNDKVLDGRRYMVGASYDF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=662, Percent_Identity=38.368580060423, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1786798, Length=749, Percent_Identity=30.5740987983979, Blast_Score=232, Evalue=7e-62,
Organism=Escherichia coli, GI1790405, Length=159, Percent_Identity=38.3647798742138, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786344, Length=232, Percent_Identity=28.8793103448276, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 73910; Mature: 73779

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVNQRFRKTHSAALVIAAVISSQGYAAEKTNTATPTDTMVVTASGFQQRIQDSAASIS
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHEEE
VVTREQIENKAYRDVTDALKDVPGVVITGGGSTSDISIRGMAAKYTLILVNGKRVDTRST
EEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEEEEEEEEEECCEECCCCC
RPNSDGSGIEQGWLPPLAAIDRIEVVRGPMSSLYGSDAMGGVINIITRKVGKEWHGTVRA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCHHHCCEEEE
DATLQEDSKSGDIFQTNAYASGPLIDGLLGLKVSGLLSHRSEDKIIDGYNQQRMRNGTAT
CCEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHCCCCEE
FTLTPDDNNEFDFDIGHYVQDRNSTPGRTLALNGTNSDTQYDRNNYAVTHNGYYDFGNST
EEECCCCCCCCCCCHHHHEECCCCCCCCEEEECCCCCCCCCCCCCEEEEECCEEECCCCC
SYIQRDETRNPSRQMKSVDNIFNTQTSFLLDNHTLILGGQYRYEELYDKGNQLPSASDLK
CEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEECCCCHHHHHHHCCCCCCCHHHHH
KLTRWSWALFAEDEWQMTNDFALTGGIRMDQDQNYGTHWTPRLYGVWHLADQWTLKGGVS
HHHHHEEEEEECCCCEECCCEEEECCEEECCCCCCCCCCCCEEEEEEEECCCEEEECCCC
GGYRSPDLRQATDDWGQLSGGGKGGLPALILGNSNLKPERSISQEIGILWDDQEGMNASV
CCCCCCCHHHHCCHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHCCEEECCCCCCCEEE
TLFYTDFKDKITEVRNCDITTNTTGQCVFNGINYKFISDRINVDKAMTRGAEATFAWDIN
EEEEECHHHHHHHHHCCCEECCCCCCEEEECCCEEEECCCCCHHHHHHCCCCEEEEEECC
QAWSLATNYTFTQSEQKSGAFAGQPLNQMPKHMLNGTLNWKTTEDFATWIRANYRGKASE
CHHHHEECCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCHHH
YLNRTSMGSRTPSYTFVDLGANYQLTKEVRLMGGVYNLLDKRVDIDVNDKVLDGRRYMVG
HHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEE
ASYDF
CCCCC
>Mature Secondary Structure 
AKVNQRFRKTHSAALVIAAVISSQGYAAEKTNTATPTDTMVVTASGFQQRIQDSAASIS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHEEE
VVTREQIENKAYRDVTDALKDVPGVVITGGGSTSDISIRGMAAKYTLILVNGKRVDTRST
EEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEEEEEEEEEECCEECCCCC
RPNSDGSGIEQGWLPPLAAIDRIEVVRGPMSSLYGSDAMGGVINIITRKVGKEWHGTVRA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCHHHCCEEEE
DATLQEDSKSGDIFQTNAYASGPLIDGLLGLKVSGLLSHRSEDKIIDGYNQQRMRNGTAT
CCEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHCCCCEE
FTLTPDDNNEFDFDIGHYVQDRNSTPGRTLALNGTNSDTQYDRNNYAVTHNGYYDFGNST
EEECCCCCCCCCCCHHHHEECCCCCCCCEEEECCCCCCCCCCCCCEEEEECCEEECCCCC
SYIQRDETRNPSRQMKSVDNIFNTQTSFLLDNHTLILGGQYRYEELYDKGNQLPSASDLK
CEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEECCCCHHHHHHHCCCCCCCHHHHH
KLTRWSWALFAEDEWQMTNDFALTGGIRMDQDQNYGTHWTPRLYGVWHLADQWTLKGGVS
HHHHHEEEEEECCCCEECCCEEEECCEEECCCCCCCCCCCCEEEEEEEECCCEEEECCCC
GGYRSPDLRQATDDWGQLSGGGKGGLPALILGNSNLKPERSISQEIGILWDDQEGMNASV
CCCCCCCHHHHCCHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHCCEEECCCCCCCEEE
TLFYTDFKDKITEVRNCDITTNTTGQCVFNGINYKFISDRINVDKAMTRGAEATFAWDIN
EEEEECHHHHHHHHHCCCEECCCCCCEEEECCCEEEECCCCCHHHHHHCCCCEEEEEECC
QAWSLATNYTFTQSEQKSGAFAGQPLNQMPKHMLNGTLNWKTTEDFATWIRANYRGKASE
CHHHHEECCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCHHH
YLNRTSMGSRTPSYTFVDLGANYQLTKEVRLMGGVYNLLDKRVDIDVNDKVLDGRRYMVG
HHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEE
ASYDF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]