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The map label for this gene is serA [H]

Identifier: 218928439

GI number: 218928439

Start: 1445988

End: 1446953

Strand: Reverse

Name: serA [H]

Synonym: YPO1288

Alternate gene names: 218928439

Gene position: 1446953-1445988 (Counterclockwise)

Preceding gene: 218928440

Following gene: 218928438

Centisome position: 31.09

GC content: 60.04

Gene sequence:

>966_bases
GTGAGCGAATCAAAAATGAGATTGGTCGTCACCGATCAGGCTTTCGGCAATACCGTTTATGAACAAGCAGCGGCCAACGC
GGTTGGTGCCGATTTCGCCGCCTATCAATGCCGCACTGAAGATGAAACGCGGGATGCCGTGCAGGGCGCAGATGTCGTGT
TGAACAACTTCGCCCCGATGACCGAGCGGGTGATGGCGGCCATGCCCCCCGGCGCGGTGATCGTGCGGTACGGCGTCGGT
GTCGATAACATCGATCTCTCTGCGGCCAGAAAACGGGGGATGCGTATTTGTAATGTGCCGGATTACGGCATTGAAGAGGT
TGCCGACCACGCCGCCGCCATGACATTGGCGTTAGCACGCAAACTGGGGCGCTACGAGGCAGGGATCCGTAGCGGCAGGT
GGGAAATTGACCAGATGGTCGATGGTGTGCGGTCATTGCGTGACACCACGGTAGGGCTGATCGGCCTTGGGCGCATCGCG
CGCGCCTATGCAACACGAATGGCGGTTTTCGGTTGCCGCATCATCGGCTTCGACCCGTATGTCACTGAGACAGAAGCCCG
TTCGGCGGGGATCGAGCCGCTGCCACAGGATAAGGTCATCGCCTCGGCCCACATCCTGTCGCTACATGTTCCGCTAACGC
CTGAAACTCGCGACCTGATCGATACCACCGCTATCGCACGTATGCCTGAGGGCGCGATCCTGATCAACTGCGCCCGTGGC
GGGCTGGTGAATGAGGTGGCCTTAATCGAGGCATTGACCCGTGGCCACCTATCGGGGGCCGGACTCGACGTCTTCGAGCA
AGAACCCCTCCCGGCTGATTCGGCCTTGCGTAAAGCGCCCCATCTCCTTCTCTCGCCCCATGCCGCTTTTTTCTCGGATG
CGTCGGTCAAAAAACTGCAACAACTGGCTTCTGAAGAGGCCCTACGGGGACTGCGCGGTGAGCCACTGCGCTGCCCACTG
ACTTAA

Upstream 100 bases:

>100_bases
TGGGCACCTTACACAATACGGTAGTCTACTCCGACGAGGCCGTTCCCTGGACCTACGGAACCCGTGCGCTGATGCGTAAC
CTTACTAAGCGGGGGGTGCT

Downstream 100 bases:

>100_bases
GGAGAAGAGGATGAATGACCACAAAAAGCGGCCTGATCTCGAAAAGCGGCCTGATCTCGAAAAACAATCTTATCCCGAAA
AACAGAGCCTGTCTGGGAAG

Product: putative D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSESKMRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTERVMAAMPPGAVIVRYGVG
VDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIA
RAYATRMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARG
GLVNEVALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRCPL
T

Sequences:

>Translated_321_residues
MSESKMRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTERVMAAMPPGAVIVRYGVG
VDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIA
RAYATRMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARG
GLVNEVALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRCPL
T
>Mature_320_residues
SESKMRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTERVMAAMPPGAVIVRYGVGV
DNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIAR
AYATRMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGG
LVNEVALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRCPLT

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=35.2941176470588, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=37.3493975903614, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=37.3493975903614, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=36.144578313253, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=36.144578313253, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=37.3493975903614, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=31.8548387096774, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=29.2490118577075, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082289, Length=227, Percent_Identity=33.4801762114537, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1789279, Length=253, Percent_Identity=28.0632411067194, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081824, Length=224, Percent_Identity=30.8035714285714, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=34.0996168582375, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=32.156862745098, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=31.0077519379845, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=223, Percent_Identity=27.8026905829596, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=240, Percent_Identity=26.25, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=244, Percent_Identity=27.0491803278689, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646446, Length=250, Percent_Identity=40.4, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646448, Length=250, Percent_Identity=40.4, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646452, Length=250, Percent_Identity=40.4, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646450, Length=250, Percent_Identity=40.4, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=40.4, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19921140, Length=238, Percent_Identity=35.2941176470588, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=29.9610894941634, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24585516, Length=288, Percent_Identity=29.5138888888889, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28571528, Length=253, Percent_Identity=31.2252964426877, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=27.3684210526316, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34521; Mature: 34390

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESKMRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPM
CCCCCEEEEEECCHHCHHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHHHHCCCHH
TERVMAAMPPGAVIVRYGVGVDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALAR
HHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHH
KLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYATRMAVFGCRIIGFDPY
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
VTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARG
CCCCHHHHCCCCCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
GLVNEVALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQ
CCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHCCCEEECCCHHHHCCHHHHHHH
QLASEEALRGLRGEPLRCPLT
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SESKMRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPM
CCCCEEEEEECCHHCHHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHHHHCCCHH
TERVMAAMPPGAVIVRYGVGVDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALAR
HHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHH
KLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYATRMAVFGCRIIGFDPY
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
VTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARG
CCCCHHHHCCCCCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
GLVNEVALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQ
CCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHCCCEEECCCHHHHCCHHHHHHH
QLASEEALRGLRGEPLRCPLT
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]