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The map label for this gene is yeiQ [H]

Identifier: 218928433

GI number: 218928433

Start: 1439154

End: 1440626

Strand: Reverse

Name: yeiQ [H]

Synonym: YPO1280

Alternate gene names: 218928433

Gene position: 1440626-1439154 (Counterclockwise)

Preceding gene: 218928435

Following gene: 218928430

Centisome position: 30.96

GC content: 51.26

Gene sequence:

>1473_bases
ATGAACACCATTGCCAACAGCGCCCTTCCCTCAACCGTACAGCAACCCAATTATGATCGGGCGGCGCTGAGAAGCCGTAT
TGTTCACATTGGATTTGGTGCTTTTCATCGAGCCCACCAGGCACTGCTCACTTACCGGGTATTAAATACGCAAGGCGGTG
ATTGGGGTATTTGCGAAGTCAGCCTCTTTGGTGCTGATACGCTGATTCAAGAGTTACGTAAACAGGACCACCTCTTTTCC
GTCTTGGAAAAAGGGGCGCAGGGTAATCAGGCGATTGTGGTCGGTTCAGTGTGTGAATCCGTACATGCTCGTTTAGACGG
CATCATGCAAGTATTGGCGAAATTGGTCGAGCCACAAGTGGCCATCGTCTCTCTGACCATCACCGAGAAAGGGTATTGCA
TCGAGCCGGGCACCGGCCAATTGGATCTGCAGAACGAGTTTATTCGTGCCGATCTGGCCGTCCCTAATGCACCGACATCA
GCACCTGGGGTGTTGGTGGAAGCACTCCGCTTGCGCCGTTTACGTGGATTGCCTCCCTTTACCGTCCTTTCTTGCGATAA
CATCCCGGAAAACGGTGATGTGGTAAGAAACGCGGTACTCGGTCTGGCCACGGTCCGTGATCCAGCGCTGGCTAATTGGA
TTCAGCAACATGTCACTTTCCCGAACACCATGGTTGACCGCATCGTTCCCGCAGCGACAGCGGAAACGTTACAGGAAATC
GCCGATACCCTTGGGGTCGCAGACTCTTGTGGGATCGCCTGCGAACCCTTTATTCAGTGGGTCGTCGAAGACAAATTTGT
TGCAGGCCGTCCAGATTGGCAAGTGGCGGGCGTACAGTTGGTTGATGATGTCTTGCCGTTTGAAGAAATGAAGCTACGTA
TGCTGAACGGGAGCCATTCGTATCTCTCTTATTTAGGCTATCTGGCCGGTTATCAACATATTAATGATTGTATGGCTGAC
GAGAATTATCGCCTAACGGCTCGTCGCTTAATGATGAATGAGCAAGCGCCCACTTTACGTGTCACCGGTATTGATCTGAA
TGCTTATGCTGATCAGTTGATTGAGCGTTACTGTAACCCCGCGCTCAAACACCGCACCTGGCAAATTGCCATGGATGGGA
GCCAGAAATTACCACAACGGATGTTGGATTCCGTCCGTTGGCATTTAAAACAGGGTAATGCGTATCCTTGTCTGGCTTTA
GGCATTGCAGGTTGGATGCGCTATGTAGGGGGCATCGATGATAACGGTCAGGTTATTGATATCCGTGATCCGATGGTGGA
TAGCTTTAAACAATGCGTTGCGGCCAGCGAAGATGGTGCGGCTCGGGTACAAAGTTTGCTGACACTGAAAGCACTGTTTG
GTGAAACGCTGCCACAACAGCCAACATTTGTGCAGGCAGTGACCGAGGCTTATCTCAGCTTGCAACAATTTGGCGCGAAA
GAGACAGTACGCCGCTTAGCCGAACAGGCTTAA

Upstream 100 bases:

>100_bases
AGCCACACAAAACTGGTCTAACAACTTTTCTATTTGCCACCTTTTATGTTAATCCCCATCAGTCCCCGTACTGTCAGGGG
GAATAATTCTGGAGCCACCT

Downstream 100 bases:

>100_bases
GACACACGACGATGAGCTGAATCAAGGCTATTCAGCTCATCGGTATTGTTGGCGTTTAGTTCTGTTGATATTAGTTCTGT
TGATATTAGTTCTGTTGACG

Product: putative D-mannonate oxidoreductase

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTYRVLNTQGGDWGICEVSLFGADTLIQELRKQDHLFS
VLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQVAIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTS
APGVLVEALRLRRLRGLPPFTVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHSYLSYLGYLAGYQHINDCMAD
ENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNPALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLAL
GIAGWMRYVGGIDDNGQVIDIRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
ETVRRLAEQA

Sequences:

>Translated_490_residues
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTYRVLNTQGGDWGICEVSLFGADTLIQELRKQDHLFS
VLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQVAIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTS
APGVLVEALRLRRLRGLPPFTVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHSYLSYLGYLAGYQHINDCMAD
ENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNPALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLAL
GIAGWMRYVGGIDDNGQVIDIRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
ETVRRLAEQA
>Mature_490_residues
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTYRVLNTQGGDWGICEVSLFGADTLIQELRKQDHLFS
VLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQVAIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTS
APGVLVEALRLRRLRGLPPFTVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHSYLSYLGYLAGYQHINDCMAD
ENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNPALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLAL
GIAGWMRYVGGIDDNGQVIDIRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
ETVRRLAEQA

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=483, Percent_Identity=63.9751552795031, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=484, Percent_Identity=57.4380165289256, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1790779, Length=489, Percent_Identity=58.8957055214724, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI48994885, Length=499, Percent_Identity=24.6492985971944, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790028, Length=254, Percent_Identity=27.1653543307087, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324401, Length=494, Percent_Identity=38.663967611336, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320765, Length=494, Percent_Identity=38.663967611336, Blast_Score=362, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 54008; Mature: 54008

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTYRVLNTQGGDWGICEV
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
SLFGADTLIQELRKQDHLFSVLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCE
AIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTSAPGVLVEALRLRRLRGLPPF
EEEEEEEECCCEEECCCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
TVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHS
HHHHCCCCCCCCCHHHHHHHHHHCCEECCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCHH
YLSYLGYLAGYQHINDCMADENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCH
ALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLALGIAGWMRYVGGIDDNGQVID
HHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
IRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHH
ETVRRLAEQA
HHHHHHHHCC
>Mature Secondary Structure
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTYRVLNTQGGDWGICEV
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
SLFGADTLIQELRKQDHLFSVLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCE
AIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTSAPGVLVEALRLRRLRGLPPF
EEEEEEEECCCEEECCCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
TVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHS
HHHHCCCCCCCCCHHHHHHHHHHCCEECCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCHH
YLSYLGYLAGYQHINDCMADENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCH
ALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLALGIAGWMRYVGGIDDNGQVID
HHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
IRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHH
ETVRRLAEQA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]