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The map label for this gene is gyrA [H]

Identifier: 218928375

GI number: 218928375

Start: 1370729

End: 1373404

Strand: Direct

Name: gyrA [H]

Synonym: YPO1216

Alternate gene names: 218928375

Gene position: 1370729-1373404 (Clockwise)

Preceding gene: 218928369

Following gene: 218928376

Centisome position: 29.45

GC content: 49.7

Gene sequence:

>2676_bases
ATGAGCGACCTTGCCAGAGAAATAACACCGGTCAACATCGAGGAAGAGCTGAAAAGCTCCTATCTGGATTATGCGATGTC
CGTTATTGTCGGACGTGCGTTACCAGATGTCCGTGATGGACTGAAACCGGTGCACCGTCGCGTACTGTTTGCGATGAATG
TACTGGGTAATGACTGGAATAAACCATACAAAAAATCGGCCCGTGTAGTCGGGGACGTTATCGGTAAATACCACCCGCAT
GGTGACAGCGCGGTCTACGACACTATCGTGCGTATGGCCCAGCCGTTCTCACTGCGCTATATGCTGGTGGATGGGCAGGG
TAACTTCGGTTCCGTCGATGGTGACTCCGCCGCGGCGATGCGTTATACCGAAATCCGTATGTCTAAAATTGCTCACGAAT
TGTTAGCGGATTTAGAAAAAGATACCGTTGACTTCGTGCCTAACTATGATGGTACGGAACAAATTCCGGCTGTTATGCCG
ACCAGAATCCCTAACCTGCTGGTAAACGGTTCGTCGGGTATTGCGGTAGGGATGGCAACCAATATTCCGCCACATAATCT
TTCTGAGGTTATTGATGGCTGTCTGGCTTATATAGAAGATGAAAACATCAGCATTGAAGGGCTGATGGAGTATATCCCTG
GCCCAGACTTCCCAACAGCAGCCATTATTAATGGCCGCCGTGGTATTGAAGAGGCTTATCGTACTGGTCGCGGTAAGGTC
TATATCCGCGCACGTGCTGAAGTCGAAGCGGATGCCAAAACGGGCCGTGAAACCATTATTGTTCATGAGATCCCGTATCA
GGTGAACAAAGCACGGTTGATTGAGAAAATCGCCGAGCTGGTAAAAGAAAAACGTGTCGAAGGCATCAGCGCGTTACGCG
ATGAGTCTGATAAAGACGGCATGCGCATCGTGATTGAAATCAAACGTGATGCGGTCGGGGAAGTGGTGCTGAATAACCTC
TACTCTCTGACACAATTGCAGGTGACTTTCGGTATCAATATGGTGGCCTTGTCTCAGGGGCAACCGAAGCTGCTTAACCT
GAAAGACATTCTGGTTGCTTTTGTTCGTCACCGTCGTGAAGTGGTGACTCGCCGTACCATTTTTGAACTGCGTAAAGCAC
GTGATCGCGCCCATATCCTTGAAGCGTTGGCGATTGCACTGGCTAACATTGATCCGATTATCGAATTGATTCGCCGTGCA
TCGACCCCTGCGGAAGCAAAAGCCGGTTTGATTGCCAGTCCTTGGGAGTTAGGTAACGTTGCTTCCATGCTGGAACGTGC
TGGTGATGACGCGGCCCGCCCTGAGTGGCTGGAAGCGGAATTTGGTATCCGTGACGGTAAATATTACCTTACCGAGCAAC
AGGCTCAGGCTATTTTGGATCTGCGTTTGCAGAAACTGACAGGTCTGGAGCATGAGAAACTGCTGGATGAGTATAAAGAG
CTGCTCACCTTAATTGGCGAGCTGATCTTTATTCTAGAAAATCCGGATCGCCTGATGGAGGTTATCCGCGAAGAATTAGT
GGCGATCAAAGAGCAATATAACGATCTTCGTCGCACTGAGATCACCGCGAATACCTCTGATATCAATATTGAAGACCTGA
TTAATCAAGAAGATGTGGTTGTGACGTTGTCCCATCAGGGCTACGTCAAATACCAGCCGTTGAGTGATTACGAAGCTCAG
CGTCGTGGTGGTAAAGGTAAATCTGCTGCACGTATCAAAGAAGAAGACTTTATTGATCGCCTGCTCGTTGCCAATACCCA
CGATACCATCTTGTGCTTCTCCAGCCGTGGCCGTCTCTATTGGATGAAGGTCTATCAACTGCCGGAAGCCAGCCGTGGGG
CTCGTGGCCGTCCCATCGTCAACTTGTTGCCGCTTGAGCCAAATGAGCGTATTACCGCCATTCTGCCTGTGCGCGAATAT
GAAGAAGGCTGTCATGTCTTTATGGCTACCGCCAGCGGTACTGTGAAGAAAACGGCATTGACGGAGTTCAGTCGCCCACG
TAGCGCCGGTATTATCGCCGTTAATTTGAACGAAGGTGATGAGCTTATCGGTGTGGATCTGACGGATGGCAGCAATGAAG
TTATGCTGTTCTCAGCATTGGGTAAAGTGGTTCGTTTCCCAGAAGGGCAGGTTCGCTCTATGGGCCGTACCGCAACCGGT
GTCCGTGGGATCAACCTCAATGGCGATGATCGGGTTATTTCTCTGATCATTCCTCGTGGTGATGGTGAAATCCTGACCGT
AACTGAAAACGGTTATGGTAAGCGTACTGCAGTGGCAGAATATCCAACCAAGTCCCGTGCGACTCAGGGGGTTATCTCCA
TTAAAGTCAGTGAGCGTAATGGTAAGGTTGTCGGTGCTGTTCAAGTTGCACCAACTGACCAAATCATGATGATCACTGAT
GCTGGCACACTGGTACGTACTCGCGTATCCGAAGTGAGTGTCGTAGGGCGTAATACCCAAGGTGTGACCCTGATCCGTAC
CGCAGAAGATGAACATGTTGTTGGTTTGCAACGTGTCGCTGAACCTGAAGAGGATGATGATATCCTTGATGGCGAATCAT
CAGAAGGTGAAGAGGGCAGCGAAGAAAACGCGGCACTAAATGCACCATCAGATGATGTTGCCGATGAAGACACTGATGCA
GAAGACGACACTGATGTAGAAGACGACAACGCATAA

Upstream 100 bases:

>100_bases
CTGTCATTTAACCCAAAACATGCAGTTTCGCCAAAATCTGCGTTTTGTGATATAGTTTCGTACCTTTAAATCCGGTAATC
AGTAGAGGGATAGCGGCTCA

Downstream 100 bases:

>100_bases
TAATGTTGCTCTGGCAGGTGCGGTTTATTGCACCTGCTCATTCATCTGCGGCGACCCAGTCTTTAGGTGATCGTGTCATT
AAAAAACAGCCAGCCAGTGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 891; Mature: 890

Protein sequence:

>891_residues
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMSKIAHELLADLEKDTVDFVPNYDGTEQIPAVMP
TRIPNLLVNGSSGIAVGMATNIPPHNLSEVIDGCLAYIEDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNL
YSLTQLQVTFGINMVALSQGQPKLLNLKDILVAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRA
STPAEAKAGLIASPWELGNVASMLERAGDDAARPEWLEAEFGIRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLTLIGELIFILENPDRLMEVIREELVAIKEQYNDLRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLSDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEPNERITAILPVREY
EEGCHVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSALGKVVRFPEGQVRSMGRTATG
VRGINLNGDDRVISLIIPRGDGEILTVTENGYGKRTAVAEYPTKSRATQGVISIKVSERNGKVVGAVQVAPTDQIMMITD
AGTLVRTRVSEVSVVGRNTQGVTLIRTAEDEHVVGLQRVAEPEEDDDILDGESSEGEEGSEENAALNAPSDDVADEDTDA
EDDTDVEDDNA

Sequences:

>Translated_891_residues
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMSKIAHELLADLEKDTVDFVPNYDGTEQIPAVMP
TRIPNLLVNGSSGIAVGMATNIPPHNLSEVIDGCLAYIEDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNL
YSLTQLQVTFGINMVALSQGQPKLLNLKDILVAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRA
STPAEAKAGLIASPWELGNVASMLERAGDDAARPEWLEAEFGIRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLTLIGELIFILENPDRLMEVIREELVAIKEQYNDLRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLSDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEPNERITAILPVREY
EEGCHVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSALGKVVRFPEGQVRSMGRTATG
VRGINLNGDDRVISLIIPRGDGEILTVTENGYGKRTAVAEYPTKSRATQGVISIKVSERNGKVVGAVQVAPTDQIMMITD
AGTLVRTRVSEVSVVGRNTQGVTLIRTAEDEHVVGLQRVAEPEEDDDILDGESSEGEEGSEENAALNAPSDDVADEDTDA
EDDTDVEDDNA
>Mature_890_residues
SDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMSKIAHELLADLEKDTVDFVPNYDGTEQIPAVMPT
RIPNLLVNGSSGIAVGMATNIPPHNLSEVIDGCLAYIEDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKVY
IRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNLY
SLTQLQVTFGINMVALSQGQPKLLNLKDILVAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAS
TPAEAKAGLIASPWELGNVASMLERAGDDAARPEWLEAEFGIRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKEL
LTLIGELIFILENPDRLMEVIREELVAIKEQYNDLRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLSDYEAQR
RGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEPNERITAILPVREYE
EGCHVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSALGKVVRFPEGQVRSMGRTATGV
RGINLNGDDRVISLIIPRGDGEILTVTENGYGKRTAVAEYPTKSRATQGVISIKVSERNGKVVGAVQVAPTDQIMMITDA
GTLVRTRVSEVSVVGRNTQGVTLIRTAEDEHVVGLQRVAEPEEDDDILDGESSEGEEGSEENAALNAPSDDVADEDTDAE
DDTDVEDDNA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=341, Percent_Identity=26.3929618768328, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI19913406, Length=316, Percent_Identity=25.6329113924051, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=878, Percent_Identity=84.9658314350797, Blast_Score=1506, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=716, Percent_Identity=36.3128491620112, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=33.5329341317365, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=33.1325301204819, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=194, Percent_Identity=28.8659793814433, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=182, Percent_Identity=29.6703296703297, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136538, Length=362, Percent_Identity=27.3480662983425, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98605; Mature: 98474

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEIRMSKIAHELLADLEKDTVDFVPNYDGTEQIPAVMPTRIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLSEVIDGCLAYIEDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEIKRDAVGEVVLNNLYSLTQLQVTFGINMVALSQGQPKLLNLKDILVAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHEEEEEECCEEEEECCCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRASTPAEAKAGLIASPWELGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHCCCCEECCCCHHHH
ASMLERAGDDAARPEWLEAEFGIRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCEECCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLTLIGELIFILENPDRLMEVIREELVAIKEQYNDLRRTEITANTSDINIEDLINQEDVV
HHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEPNERITAILPVREYEEGCHVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHCCCCEEEEEECCCCCHHHHH
TEFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSALGKVVRFPEGQVRSMGRTATG
HHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEHHHHHHHHCCCCHHHHHCCCCCCC
VRGINLNGDDRVISLIIPRGDGEILTVTENGYGKRTAVAEYPTKSRATQGVISIKVSERN
EEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEEECCC
GKVVGAVQVAPTDQIMMITDAGTLVRTRVSEVSVVGRNTQGVTLIRTAEDEHVVGLQRVA
CEEEEEEEECCCCCEEEEECCCHHHHHHHHHEEEEECCCCCEEEEEECCCCHHHHHHHHC
EPEEDDDILDGESSEGEEGSEENAALNAPSDDVADEDTDAEDDTDVEDDNA
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEIRMSKIAHELLADLEKDTVDFVPNYDGTEQIPAVMPTRIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLSEVIDGCLAYIEDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEIKRDAVGEVVLNNLYSLTQLQVTFGINMVALSQGQPKLLNLKDILVAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHEEEEEECCEEEEECCCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRASTPAEAKAGLIASPWELGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHCCCCEECCCCHHHH
ASMLERAGDDAARPEWLEAEFGIRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCEECCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLTLIGELIFILENPDRLMEVIREELVAIKEQYNDLRRTEITANTSDINIEDLINQEDVV
HHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEPNERITAILPVREYEEGCHVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHCCCCEEEEEECCCCCHHHHH
TEFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSALGKVVRFPEGQVRSMGRTATG
HHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEHHHHHHHHCCCCHHHHHCCCCCCC
VRGINLNGDDRVISLIIPRGDGEILTVTENGYGKRTAVAEYPTKSRATQGVISIKVSERN
EEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEEECCC
GKVVGAVQVAPTDQIMMITDAGTLVRTRVSEVSVVGRNTQGVTLIRTAEDEHVVGLQRVA
CEEEEEEEECCCCCEEEEECCCHHHHHHHHHEEEEECCCCCEEEEEECCCCHHHHHHHHC
EPEEDDDILDGESSEGEEGSEENAALNAPSDDVADEDTDAEDDTDVEDDNA
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7642123 [H]