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The map label for this gene is yclK [H]

Identifier: 218906438

GI number: 218906438

Start: 5049430

End: 5050860

Strand: Reverse

Name: yclK [H]

Synonym: BCAH820_5352

Alternate gene names: 218906438

Gene position: 5050860-5049430 (Counterclockwise)

Preceding gene: 218906439

Following gene: 218906437

Centisome position: 95.25

GC content: 38.78

Gene sequence:

>1431_bases
ATGTCTTTGAAAAGAAATATGGTGTTTGGAATCGTTGGACTGTTAATCCCGATTTTTGTTCTTTTGTACGCAGTTGTTTA
TATTACGTTAGAAAAGAATATGTATCATAACGCTGCAAATTCTTTAGAAAAGTTAAGTGTAGAAGCACAAATTTATACGA
TGAATTATTTAGAGAAGGAAGCAGAGGTAGAGACGCTCGGTCCGAATTCACTTTTAATTGCTTCGTATTTAGCGAAGCGC
ATGGATGTCCGTGTACAGATGATTGGGAAGAATGGAGATGTTGTTGCGGATACGCAAAAGGGAGCACTTCTTCATCGGAA
TATTGATATTGAGAGTTCTTTGAAAGGGAAGAAATCTTATGTTTTTGAAGAGGGCGATCCAGCTCCAATCCTTCTGTTTT
CAAGCCCAGTATATTATGGAAACGATGTCATTGGAAGTGTTCGTTTTATAAATGAGTTAACGGGTGAGAAGGAAGTTTTA
ACAAATGTCGGTTGGACGTTCTTAATGACGTCTCTTTGTCTCGTAGCTGCGGGTATTTTCTTTGCAATTCGTTTGGCAAA
GTCTCTCCATAAGCCGATTGATCAGTTAAGACAAATGGCACACCGGCTTGCGAATGGTGATTATAAAAGTAAGATTGAGC
TAAATGAATATGTGGAAATTGCTCAGCTTTCCGCATCTTTTAATGCAATGGCCGATGGAATTGAACTGCATATTAAGCAA
TTGAAAGAGGAGAAAGAGAAGCAGAAAGATTTCCTAGACCGCATTACGCATGAGCTGAAAACACCGCTAACGGCAATTAT
TGGCTATGTGGATTTAATTCCGAAGTTAAAAGCGAAGGAAGATGTAAAGGAGAGCTTGCGTTATGTGGCTGTAGAAAGTG
AGCGTTTATTGTCACTTGTAGAGGAATTACTTAAGTCTTCAAAGTACGGAACGAGTACGTTTGAAATATCACCTACAGTT
GTGAATATAAAGGAATTAGCCGAAGAAGCAGTTTCAATTGTGAAACCTCGCCTGCAGAAATTTGAGATTGAAGTTATCAA
TGAGTTAACAGATGTACATGTTGTTGCGGATTTCGATAAGACGAAACAGATCTTCTTAAATGTGCTTGATAATGCGATAA
AATATAGCGATGCTACGCAAATTCGTATGAATGTCATTGTAAATGAACGTGAGGCAAAAGTTTTTGTTCATGATGATGGC
ATCGGTATCGATGAAGGTGTGCTGGCAGAGTGGAATGAATCGCCGGAAGGGAAGGTTCTCCCTTCTAGTTACGGGAATGG
TTACGGTTTGTATATTTGTCAGGAGATTATGGATAAGCAGGGCGGAAGTATGCGGATTGAGAGTAGTGAAGAAATAGGCA
CTACCATATTTATTACATTCTTGCTTCCGAGACGAATGGAAGATATAAAAAATCTGAAAGCGGTTAAATGA

Upstream 100 bases:

>100_bases
TTATGGTGCAAAGATTGCGGAAGAAGCTAGGGAATAGCGGTGAATATATTAAGACCATTTATGGCGTTGGCTATAAACTG
GATTGTTAAGTGGTGATGGT

Downstream 100 bases:

>100_bases
TACATTTATGAAACAATTATGCGGTATTTTCGAAACAACGTTTTTTTATCTTGGAGGTAGGCAGAAATGAAAAGGCTATC
ATTTCAAATTCTTATGTTTG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSLKRNMVFGIVGLLIPIFVLLYAVVYITLEKNMYHNAANSLEKLSVEAQIYTMNYLEKEAEVETLGPNSLLIASYLAKR
MDVRVQMIGKNGDVVADTQKGALLHRNIDIESSLKGKKSYVFEEGDPAPILLFSSPVYYGNDVIGSVRFINELTGEKEVL
TNVGWTFLMTSLCLVAAGIFFAIRLAKSLHKPIDQLRQMAHRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQ
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVKESLRYVAVESERLLSLVEELLKSSKYGTSTFEISPTV
VNIKELAEEAVSIVKPRLQKFEIEVINELTDVHVVADFDKTKQIFLNVLDNAIKYSDATQIRMNVIVNEREAKVFVHDDG
IGIDEGVLAEWNESPEGKVLPSSYGNGYGLYICQEIMDKQGGSMRIESSEEIGTTIFITFLLPRRMEDIKNLKAVK

Sequences:

>Translated_476_residues
MSLKRNMVFGIVGLLIPIFVLLYAVVYITLEKNMYHNAANSLEKLSVEAQIYTMNYLEKEAEVETLGPNSLLIASYLAKR
MDVRVQMIGKNGDVVADTQKGALLHRNIDIESSLKGKKSYVFEEGDPAPILLFSSPVYYGNDVIGSVRFINELTGEKEVL
TNVGWTFLMTSLCLVAAGIFFAIRLAKSLHKPIDQLRQMAHRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQ
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVKESLRYVAVESERLLSLVEELLKSSKYGTSTFEISPTV
VNIKELAEEAVSIVKPRLQKFEIEVINELTDVHVVADFDKTKQIFLNVLDNAIKYSDATQIRMNVIVNEREAKVFVHDDG
IGIDEGVLAEWNESPEGKVLPSSYGNGYGLYICQEIMDKQGGSMRIESSEEIGTTIFITFLLPRRMEDIKNLKAVK
>Mature_475_residues
SLKRNMVFGIVGLLIPIFVLLYAVVYITLEKNMYHNAANSLEKLSVEAQIYTMNYLEKEAEVETLGPNSLLIASYLAKRM
DVRVQMIGKNGDVVADTQKGALLHRNIDIESSLKGKKSYVFEEGDPAPILLFSSPVYYGNDVIGSVRFINELTGEKEVLT
NVGWTFLMTSLCLVAAGIFFAIRLAKSLHKPIDQLRQMAHRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQL
KEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVKESLRYVAVESERLLSLVEELLKSSKYGTSTFEISPTVV
NIKELAEEAVSIVKPRLQKFEIEVINELTDVHVVADFDKTKQIFLNVLDNAIKYSDATQIRMNVIVNEREAKVFVHDDGI
GIDEGVLAEWNESPEGKVLPSSYGNGYGLYICQEIMDKQGGSMRIESSEEIGTTIFITFLLPRRMEDIKNLKAVK

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=25, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=25.5952380952381, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1789149, Length=338, Percent_Identity=22.7810650887574, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=24.9084249084249, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=25, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788549, Length=213, Percent_Identity=27.2300469483568, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=23.9130434782609, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787894, Length=272, Percent_Identity=23.1617647058824, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790861, Length=386, Percent_Identity=22.7979274611399, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=22.707423580786, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=23.5537190082645, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53571; Mature: 53440

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKRNMVFGIVGLLIPIFVLLYAVVYITLEKNMYHNAANSLEKLSVEAQIYTMNYLEKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEHHHHHHH
AEVETLGPNSLLIASYLAKRMDVRVQMIGKNGDVVADTQKGALLHRNIDIESSLKGKKSY
CCCEECCCCHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCEEEEECCCCHHCCCCCCCE
VFEEGDPAPILLFSSPVYYGNDVIGSVRFINELTGEKEVLTNVGWTFLMTSLCLVAAGIF
EEECCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
FAIRLAKSLHKPIDQLRQMAHRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVKESLRYVAVESERLLSLV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHH
EELLKSSKYGTSTFEISPTVVNIKELAEEAVSIVKPRLQKFEIEVINELTDVHVVADFDK
HHHHHCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHH
TKQIFLNVLDNAIKYSDATQIRMNVIVNEREAKVFVHDDGIGIDEGVLAEWNESPEGKVL
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
PSSYGNGYGLYICQEIMDKQGGSMRIESSEEIGTTIFITFLLPRRMEDIKNLKAVK
CCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLKRNMVFGIVGLLIPIFVLLYAVVYITLEKNMYHNAANSLEKLSVEAQIYTMNYLEKE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEHHHHHHH
AEVETLGPNSLLIASYLAKRMDVRVQMIGKNGDVVADTQKGALLHRNIDIESSLKGKKSY
CCCEECCCCHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCEEEEECCCCHHCCCCCCCE
VFEEGDPAPILLFSSPVYYGNDVIGSVRFINELTGEKEVLTNVGWTFLMTSLCLVAAGIF
EEECCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
FAIRLAKSLHKPIDQLRQMAHRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVKESLRYVAVESERLLSLV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHH
EELLKSSKYGTSTFEISPTVVNIKELAEEAVSIVKPRLQKFEIEVINELTDVHVVADFDK
HHHHHCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHH
TKQIFLNVLDNAIKYSDATQIRMNVIVNEREAKVFVHDDGIGIDEGVLAEWNESPEGKVL
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
PSSYGNGYGLYICQEIMDKQGGSMRIESSEEIGTTIFITFLLPRRMEDIKNLKAVK
CCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]