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The map label for this gene is gltP [H]

Identifier: 218906392

GI number: 218906392

Start: 4999094

End: 5000311

Strand: Direct

Name: gltP [H]

Synonym: BCAH820_5306

Alternate gene names: 218906392

Gene position: 4999094-5000311 (Clockwise)

Preceding gene: 218906388

Following gene: 218906393

Centisome position: 94.27

GC content: 38.62

Gene sequence:

>1218_bases
ATGAAGGCATATCGCTTTCCACTTATTTTATTATCTTCTATCCTAATTGGTGGTTTCATTGGTTATTTCATGGGTGCCGA
TGCCGTTGCTTTAAAGCCGCTTGGTGACATTTTCTTAAACTTAATGTTTACGATTGTTGTACCGTTAGTGTTCTTTAGCA
TCGCGTCATCTATTGCTAATATGGATGGATTAAAACGTTTCGGTAAAATTATGTCTAGTATGGCTGGGACTTTCTTATTT
ACAAGTATTTTAGCTGCTATTTTTATGATTATTGTCGTGAAAGTATTCCCGCCAGCACAAGGTGTTGTATTAGAATTAAC
ACAACCTGACAAAGCTGAAAAAGCGGTTAGCGTTGCAGATCAAATTGTTGGTATTCTAACAGTATCTGATTTCTCAAAGT
TACTATCTCGCGAAAATATGTTAGCACTTATTTTCTTCTCTATCTTAATGGGGATTGCAACTTCAGCAGTTGGTGAAAAA
GGAAAACCATTCGCTACATTCTTACAAGCTGGTGCAGAAATTTCAATGAAAGTTGTATCTTTCATTATGTACTACGCTCC
AATTGGACTTGCTGCTTACTTCGCAGCATTAGTTGGTGAATTCGGACCACAACTTCTTGGAACTTACTTCCGAGCAGCAA
TGGTATACTATCCAGCGTCTCTCATTTACTTCTTTGTATTCTTTACGTTCTATGCATACCTTGCAKGTCGCAAGCAAGGT
GTACAAGTATTTTGGAAGAACATGGTCTCTCCTACAGTTACATCACTAGCAACTTGTAGTAGTGCTGCTAGTATTCCAGC
GAACTTAGAAGCAACGAAGAAAATGGGTATCTCTTCTGATGTTCGTGAAACAGTTGTCCTTCTTGGATCTACACTTCATA
AAGACGGATCTGTTTTAGGCGGCGTATTAAAAATTGCTTTCTTATTCGGTATTTTCAACATGGAATTCGAAGGACCGAAA
ACATTAGCAATCGCACTTGTTGTTTCTCTATTAGTAGGAACAGTAATGGGCGCTATTCCAGGCGGCGGTATGATTGGTGA
AATGTTAATCGTTTCTCTATACGGATTCCCGCCAGAAGCATTACCAATTATTGCAGCAATTAGTACAATCATTGATCCTC
CTGCAACAATGTTAAACGTAACAGCCGATAACGCTTGTGCCGTAATGACAGCTCGCCTTGTAGAAGGTAAGAACTGGATC
AAAAACAAATTTGCTTAA

Upstream 100 bases:

>100_bases
TTCACGCTATTCCATCTATCAGTATTCTCCTAGTAAAGAGGGCTCTAACTCGCTATAATAATTCAGTATGATTTTTTATG
ATTGATAGGAGGGTATATTT

Downstream 100 bases:

>100_bases
TAGATAGAAAGAGGATGCTCCTAACGAGCATCCTCTTTTTTTGATGTTAAGCCACTCCGCCACAAATTTGTTAAAATCTT
CACAAATATTCCACATCCAT

Product: putative proton/glutamate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKAYRFPLILLSSILIGGFIGYFMGADAVALKPLGDIFLNLMFTIVVPLVFFSIASSIANMDGLKRFGKIMSSMAGTFLF
TSILAAIFMIIVVKVFPPAQGVVLELTQPDKAEKAVSVADQIVGILTVSDFSKLLSRENMLALIFFSILMGIATSAVGEK
GKPFATFLQAGAEISMKVVSFIMYYAPIGLAAYFAALVGEFGPQLLGTYFRAAMVYYPASLIYFFVFFTFYAYLAXRKQG
VQVFWKNMVSPTVTSLATCSSAASIPANLEATKKMGISSDVRETVVLLGSTLHKDGSVLGGVLKIAFLFGIFNMEFEGPK
TLAIALVVSLLVGTVMGAIPGGGMIGEMLIVSLYGFPPEALPIIAAISTIIDPPATMLNVTADNACAVMTARLVEGKNWI
KNKFA

Sequences:

>Translated_405_residues
MKAYRFPLILLSSILIGGFIGYFMGADAVALKPLGDIFLNLMFTIVVPLVFFSIASSIANMDGLKRFGKIMSSMAGTFLF
TSILAAIFMIIVVKVFPPAQGVVLELTQPDKAEKAVSVADQIVGILTVSDFSKLLSRENMLALIFFSILMGIATSAVGEK
GKPFATFLQAGAEISMKVVSFIMYYAPIGLAAYFAALVGEFGPQLLGTYFRAAMVYYPASLIYFFVFFTFYAYLAXRKQG
VQVFWKNMVSPTVTSLATCSSAASIPANLEATKKMGISSDVRETVVLLGSTLHKDGSVLGGVLKIAFLFGIFNMEFEGPK
TLAIALVVSLLVGTVMGAIPGGGMIGEMLIVSLYGFPPEALPIIAAISTIIDPPATMLNVTADNACAVMTARLVEGKNWI
KNKFA
>Mature_405_residues
MKAYRFPLILLSSILIGGFIGYFMGADAVALKPLGDIFLNLMFTIVVPLVFFSIASSIANMDGLKRFGKIMSSMAGTFLF
TSILAAIFMIIVVKVFPPAQGVVLELTQPDKAEKAVSVADQIVGILTVSDFSKLLSRENMLALIFFSILMGIATSAVGEK
GKPFATFLQAGAEISMKVVSFIMYYAPIGLAAYFAALVGEFGPQLLGTYFRAAMVYYPASLIYFFVFFTFYAYLAXRKQG
VQVFWKNMVSPTVTSLATCSSAASIPANLEATKKMGISSDVRETVVLLGSTLHKDGSVLGGVLKIAFLFGIFNMEFEGPK
TLAIALVVSLLVGTVMGAIPGGGMIGEMLIVSLYGFPPEALPIIAAISTIIDPPATMLNVTADNACAVMTARLVEGKNWI
KNKFA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=253, Percent_Identity=25.296442687747, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=25.0996015936255, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=25.0996015936255, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI40254478, Length=425, Percent_Identity=23.0588235294118, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI5032093, Length=251, Percent_Identity=25.0996015936255, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194239697, Length=268, Percent_Identity=25, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI169790839, Length=274, Percent_Identity=25.5474452554745, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI66773030, Length=251, Percent_Identity=25.0996015936255, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4827012, Length=274, Percent_Identity=24.8175182481752, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=26.2773722627737, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=23.8916256157635, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788024, Length=298, Percent_Identity=25.1677852348993, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=383, Percent_Identity=24.0208877284595, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996953, Length=419, Percent_Identity=22.673031026253, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193206505, Length=413, Percent_Identity=22.0338983050847, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193206654, Length=421, Percent_Identity=23.0403800475059, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71983106, Length=433, Percent_Identity=20.0923787528868, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983099, Length=433, Percent_Identity=20.0923787528868, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583025, Length=408, Percent_Identity=24.7549019607843, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137668, Length=408, Percent_Identity=24.7549019607843, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583023, Length=408, Percent_Identity=24.7549019607843, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43278; Mature: 43278

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751298; 9384377 [H]