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The map label for this gene is argH2 [H]

Identifier: 218905859

GI number: 218905859

Start: 4495097

End: 4496485

Strand: Reverse

Name: argH2 [H]

Synonym: BCAH820_4747

Alternate gene names: 218905859

Gene position: 4496485-4495097 (Counterclockwise)

Preceding gene: 218905860

Following gene: 218905858

Centisome position: 84.8

GC content: 38.88

Gene sequence:

>1389_bases
GTGAGCAAACTTTGGGGCGGACGTTTTACGGAAGAAGCGGAAGCGTGGGTTGAAGAGTTCGGAGCGTCCATCTCCTTCGA
TCAACAATTAGTAAATCAAGATATAAACGGAAGTATTGCACACGTAACGATGCTAGCAAAGCAAGGCATCGTTACGAAAG
AAGAAGCAGAGAAAATAAAGATAGGTCTTCAATATTTATTAGAAGAAGCGAAACAAAATAAATTGCATTTTTCCGTTGAA
GCGGAAGACATTCATTTAAATATTGAAAAGATGTTAATTGAAAAAATCGGTGAAGTAGGCGGGAAACTTCATACTGGCCG
AAGTCGTAACGATCAAGTAGCGACAGATATGCACTTATATTTAAAAGAAAAAGTAGAGCATATTATGAAAGCTACAAAAC
AATTGCAGACGGTTCTTGTTCATCAAGCAGAAAATAATATTGAAACAATTATGCCTGGCTATACGCACTTACAGCGTGCC
CAGCCAATTTCATTTGCGCATCATATTCTCGCTTATTTTTGGATGTTAGAGCGCGATGTGAATCGTTATGAAGATTCGTT
AAAGCGTATTAACATTTCACCATTAGGAGCAGGAGCGTTAGCTGGGACAACATTCCCGATTGACCGAGAATATAGTGCGG
AGCTTCTTGGATTGAATGGAATCTATGAAAATAGTTTAGATGCAGTAAGCGATCGCGATTTCATATTGGAGTTCCTCAGT
AACTCATCTATGCTTATGATGCACTTATCACGCTTTTGCGAAGAACTTATTTTATGGAGTAGCCAAGAGTTTCAATTTAT
TGAAATGAGCGATCAATACGCAACAGGAAGCAGCATTATGCCGCAAAAGAAAAATCCAGATATGGCGGAACTTATTCGTG
GTAAAACAGGCAGAGTGTACGGTAATTTATTTAGCTTACTTACAGTAATGAAAGGATTGCCGCTCGCTTACAATAAAGAC
TTGCAAGAAGATAAAGAAGGAATGTTTGATACAGTAAAAACAGTAGAAGGATGCCTTCATATTATGGCAGGCATGCTAGA
GACGATGACTGTCAACAAAGAAAAAATGGGGCAAGCTGTAACGCAAGATTTCTCTAACGCAACAGAAATTGCTGACTACT
TAGCAAACAAAGGACTACCATTCCGTCAAGCTCATGAAATTGTTGGAAAGCTAGTGCTGCACTGCACACAAAAAGGAATT
TATTTAGTAGATGTACCACTTGCAACATATAAAGAAATGAGCTCGTTATTTGAAGAAGATTTGTATGAAGTGCTGTCACC
ATATGCAGCTGTAAAGCGTCGTAACAGTGCTGGCGGGACAGGATTTGAACAGATTGAAAAGGCTTTGGAGAAGGCGAAAG
GATTAACGAAAGAAGCTATTAAGAATTGA

Upstream 100 bases:

>100_bases
CTCAGGATGAATTTAATCATGATGCAGCAGTTGGGTTCATTTCATTATTCGGTTTACCGACGAAAGTATACAGCCAAGTG
AATCAAAAGAAGGTGGAAGC

Downstream 100 bases:

>100_bases
GTTGAAAAGTACGCCAGTCTGTTAAAGTCTGGCGTACTTTCTTTTTTACTAGTATTTAAGTTATGATATAGTGAAAAATA
ACAATTTAGGGGAAGTCTAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVE
AEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
NSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGI
YLVDVPLATYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN

Sequences:

>Translated_462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVE
AEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
NSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGI
YLVDVPLATYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
>Mature_461_residues
SKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVEA
EDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRAQ
PISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLSN
SSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDL
QEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGIY
LVDVPLATYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=453, Percent_Identity=44.1501103752759, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI68303542, Length=453, Percent_Identity=44.1501103752759, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI68303549, Length=453, Percent_Identity=41.7218543046358, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI68303547, Length=453, Percent_Identity=41.5011037527594, Blast_Score=356, Evalue=3e-98,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=49.1150442477876, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17553882, Length=226, Percent_Identity=28.3185840707965, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32565146, Length=208, Percent_Identity=28.8461538461538, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=454, Percent_Identity=45.8149779735683, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=39.4335511982571, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=39.4335511982571, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52121; Mature: 51990

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIK
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
IGLQYLLEEAKQNKLHFSVEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
HHHHHHHHEECCCCCCCCHHCCCCCCCCCCCCHHHCCCCCCHHCCCHHHCHHHHHHHHHC
NSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVY
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGIYLVDVPLATYKEMSSLFEED
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
SKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIK
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
IGLQYLLEEAKQNKLHFSVEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGLNGIYENSLDAVSDRDFILEFLS
HHHHHHHHEECCCCCCCCHHCCCCCCCCCCCCHHHCCCCCCHHCCCHHHCHHHHHHHHHC
NSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVY
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGIYLVDVPLATYKEMSSLFEED
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA