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The map label for this gene is loN [H]

Identifier: 218905672

GI number: 218905672

Start: 4314526

End: 4316856

Strand: Reverse

Name: loN [H]

Synonym: BCAH820_4557

Alternate gene names: 218905672

Gene position: 4316856-4314526 (Counterclockwise)

Preceding gene: 218905673

Following gene: 218905671

Centisome position: 81.41

GC content: 39.12

Gene sequence:

>2331_bases
ATGTCTAGTATGAATACGAATGAAAGAATCGTACCCCTCCTACCATTAAGAGGCGTTCTCGTATATCCAACGATGGTTCT
GCATCTTGATGTAGGACGTGATAAATCGATACAAGCACTAGAGCAGGCGGCAATGGATGAAAATATCATCTTTTTAGCAA
TGCAAAAAGAAATGAATATCGATGATCCGAAAGAAGATGACATATATAGTGTAGGTACAGTGGCGAAAGTGAAGCAAATG
TTAAAATTGCCGAACGGTACGCTTCGTGTCCTTGTAGAAGGTTTACATAGAGCAGAAGTAGTAGAGTTTATCGAAGAAGA
AAATGTAGTGCAAGTTTCTATTAAAACGGTAACTGAAGAAATGGAAGCTGATTTAGAAGAGAAAGCTCTTATGCGTACAT
TACTGGAGCATTTCGAACAATATATTAAAGTTTCGAAAAAAGTTTCAAATGAAACATTTGCAACGGTAGCTGATGTAGAA
GAGCCAGGAAGATTAGCGGATTTAATTGCTTCTCACTTGCCAATTAAAACGAAGCAGAAACAAGAGATTTTAGAAATCAT
ATCTGTGAAAGAACGATTACATACACTTATTTCAATTATTCAAGATGAACAAGAATTACTTAGTTTAGAAAAGAAAATTG
GACAAAAAGTGAAACGTTCAATGGAGCGCACGCAAAAAGAATATTTCTTGCGTGAGCAAATGAAGGCGATTCAAACTGAA
CTTGGCGATAAAGAAGGCAAGGGCGGGGAAGTTGAAGAACTTCGTGAGAAAATTGAACAGTCAGGAATGCCTGAAGAAAC
AATGAAGGCTGCGCTGAAAGAATTAGATCGTTATGAAAAGTTACCAGCAAGTTCTGCGGAGAGCGGTGTTATTCGCAATT
ATATGGATTGGTTATTAGCACTTCCGTGGACAGACGCAACGGAAGATATGATTGATCTTGCTCATTCGGAAGAGATTTTA
AACAAAGATCATTACGGTCTTGAGAAAGTGAAAGAGCGCGTACTAGAATATTTAGCGGTACAGAAGTTAACGAATTCATT
AAAAGGGCCTATCCTTTGTTTAGTAGGGCCACCTGGGGTCGGAAAAACTTCGTTAGCGCGTTCTATTGCGACATCATTAA
ATCGTAATTTTGTCCGTGTATCCCTTGGTGGTGTGCGTGATGAATCTGAAATTCGTGGTCACCGTCGTACGTACGTTGGA
GCAATGCCAGGACGCATTATTCAAGGTATGAAAAAGGCAAAATCAGTTAATCCAGTCTTCTTATTAGATGAGATTGATAA
AATGTCTAACGATTTCCGTGGAGATCCTTCAGCAGCATTACTTGAAGTGTTAGATCCAGAACAAAACCATAACTTCAGTG
ATCATTATATTGAAGAACCATATGATCTATCGAAAGTTATGTTTGTAGCAACTGCGAATACACTTTCAAGTATTCCAGGC
CCATTACTTGACCGTATGGAAATTATTTCGATTGCTGGCTATACAGAACTTGAAAAAGTTCATATTGCTCGTGAACATTT
ATTACCGAAACAATTACAAGAGCATGGCTTACGAAAAGGTAATTTACAAGTACGTGATGAAGCGCTTCTTGAAATTATTC
GCTATTATACACGTGAGGCTGGTGTTCGTACACTAGAGCGCCAAATTGCAAAGGTTTGTCGTAAAGCAGCAAAAATTATC
GTTACAGCAGAACGTAAGCGTATTGTAGTGACAGAGAAAAACGTTGTTGATTTACTTGGTAAGCACATATTCCGTTATGG
GCAAGCTGAAAAAACAGACCAAGTTGGTATGGCGACAGGTTTAGCGTATACGGCAGCAGGCGGCGATACACTGGCGATTG
AAGTGTCCGTAGCGCCAGGTAAAGGGAAATTAATTTTAACAGGGAAACTTGGGGATGTTATGAAAGAATCCGCACAAGCG
GCGTTTAGTTATATTCGTTCTCGTGCAGAAGAGCTTCAGATTGATCCTGATTTCCATGAAAAAAATGATATTCATATTCA
TGTTCCAGAAGGAGCAGTTCCAAAAGATGGACCGTCAGCAGGTATTACGATGGCAACGGCACTTATTTCTGCGCTAACAG
GTATTCCTGTAAGTAAAGAAGTGGGGATGACAGGTGAAATTACACTTCGTGGTCGTGTATTACCGATTGGTGGTTTAAAA
GAAAAAACATTAAGTGCTCACCGCGCAGGTTTAACAAAAATTATTTTACCGGCGGAAAATGAGAAAGATTTAGATGATAT
TCCAGAGAGCGTAAAAGAAAACCTTACGTTTGTGCTTGCATCTCATTTAGATGAAGTATTGGAGCACGCATTAGTAGGAG
TGAAACAATGA

Upstream 100 bases:

>100_bases
AAAAGCGGGATTTACAGTTGCGGAGAATCTCGGCAATTGCATCTAGATGTATTGTAATATAAAATGGTTGAACAGGAGTT
TAATTTATTATGGAGGTGCT

Downstream 100 bases:

>100_bases
AAGTAACAAAAGCAGACATTGTAATTAGTGCTGTTAAACCAGAACAATATCCAGACGGTGACTTACCAGAAATCGCATTA
GCAGGTCGTTCAAATGTCGG

Product: ATP-dependent protease La 1

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 776; Mature: 775

Protein sequence:

>776_residues
MSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQM
LKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEMEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVE
EPGRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTE
LGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEIL
NKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVG
AMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPG
PLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVCRKAAKII
VTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQA
AFSYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLK
EKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Sequences:

>Translated_776_residues
MSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQM
LKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEMEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVE
EPGRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTE
LGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEIL
NKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVG
AMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPG
PLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVCRKAAKII
VTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQA
AFSYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLK
EKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
>Mature_775_residues
SSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQML
KLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEMEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEE
PGRLADLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTEL
GDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEILN
KDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGA
MPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPGP
LLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVCRKAAKIIV
TAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAA
FSYIRSRAEELQIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKE
KTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=780, Percent_Identity=41.6666666666667, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI21396489, Length=692, Percent_Identity=42.9190751445087, Blast_Score=559, Evalue=1e-159,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=54.1069100391134, Blast_Score=842, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=656, Percent_Identity=41.7682926829268, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=785, Percent_Identity=36.4331210191083, Blast_Score=479, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=38.3216783216783, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=698, Percent_Identity=43.4097421203438, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24666867, Length=698, Percent_Identity=43.4097421203438, Blast_Score=560, Evalue=1e-159,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86496; Mature: 86365

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNI
CCCCCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DDPKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEE
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
MEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPGRLADLIASHLPIKTKQK
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
QEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLA
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
LPWTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGV
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVF
CHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHEECCCCHHHHHHHHHHCCCCCEE
LLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPG
EHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEHHHHHHCCC
PLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREA
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHH
GVRTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATG
HHHHHHHHHHHHHHHHHHEEEEECCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHC
LAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPDFHE
CEEEECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLK
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCH
EKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSMNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNI
CCCCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DDPKEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEE
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
MEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPGRLADLIASHLPIKTKQK
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
QEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLA
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
LPWTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGV
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVF
CHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHEECCCCHHHHHHHHHHCCCCCEE
LLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPG
EHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEHHHHHHCCC
PLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREA
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHH
GVRTLERQIAKVCRKAAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATG
HHHHHHHHHHHHHHHHHHEEEEECCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHC
LAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPDFHE
CEEEECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLK
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCH
EKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA