Click here to switch to the map view.

The map label for this gene is merR [H]

Identifier: 218905652

GI number: 218905652

Start: 4293209

End: 4293607

Strand: Reverse

Name: merR [H]

Synonym: BCAH820_4537

Alternate gene names: 218905652

Gene position: 4293607-4293209 (Counterclockwise)

Preceding gene: 218905653

Following gene: 218905651

Centisome position: 80.97

GC content: 36.09

Gene sequence:

>399_bases
ATGCAATTTCGTATTGGAGAACTGGCTGAGAAGTGCAGCGTTAATAAAGAGACTATTCGATATTATGAACGTATAGGCTT
AATTCCAGAACCTGATCGTACGGAATCAGGATACCGCATGTATTCACAACAAATTATCGATCGATTGAATTTCATAAAAG
GGATGCAGGAACTAGGTTTTACATTAAATGAAATTGACAAATTACTAGGAGTCGTCGATCGCGATGAATCGAAGTGCCGT
GATATGTATGATTTCACTGTTTTTAAGTTAGAGGACATCCAGCGTAAAATTGAAGGTCTCAAAAGAATTGAACAAATGCT
GATGGATCTTAAAGAAAGATGTCCCGAAAACAAAGATATTTACGAATGCCCCATTATTGAAACACTGATGAAGAAATAA

Upstream 100 bases:

>100_bases
ACACTTTGGTATAAGAAAGCAAATCGATAATATAGTAAATAATACTTCCCTTGACCCTGTACTATGGTACAGGGTTTATA
CTTTATATGAGGTGAGATAA

Downstream 100 bases:

>100_bases
GAGGTGAAACAGGATGAAAAACACAATAAAAAGTTCGGGATGGTTTCTTGTCGCACTAATCACATGTCCGTGCCATTTAT
TTTTACTGCTTCCGTTGTTT

Product: Hg(II)-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MQFRIGELAEKCSVNKETIRYYERIGLIPEPDRTESGYRMYSQQIIDRLNFIKGMQELGFTLNEIDKLLGVVDRDESKCR
DMYDFTVFKLEDIQRKIEGLKRIEQMLMDLKERCPENKDIYECPIIETLMKK

Sequences:

>Translated_132_residues
MQFRIGELAEKCSVNKETIRYYERIGLIPEPDRTESGYRMYSQQIIDRLNFIKGMQELGFTLNEIDKLLGVVDRDESKCR
DMYDFTVFKLEDIQRKIEGLKRIEQMLMDLKERCPENKDIYECPIIETLMKK
>Mature_132_residues
MQFRIGELAEKCSVNKETIRYYERIGLIPEPDRTESGYRMYSQQIIDRLNFIKGMQELGFTLNEIDKLLGVVDRDESKCR
DMYDFTVFKLEDIQRKIEGLKRIEQMLMDLKERCPENKDIYECPIIETLMKK

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=125, Percent_Identity=33.6, Blast_Score=83, Evalue=6e-18,
Organism=Escherichia coli, GI1789687, Length=130, Percent_Identity=33.0769230769231, Blast_Score=82, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15814; Mature: 15814

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRIGELAEKCSVNKETIRYYERIGLIPEPDRTESGYRMYSQQIIDRLNFIKGMQELGF
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
TLNEIDKLLGVVDRDESKCRDMYDFTVFKLEDIQRKIEGLKRIEQMLMDLKERCPENKDI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YECPIIETLMKK
CCCHHHHHHHCC
>Mature Secondary Structure
MQFRIGELAEKCSVNKETIRYYERIGLIPEPDRTESGYRMYSQQIIDRLNFIKGMQELGF
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
TLNEIDKLLGVVDRDESKCRDMYDFTVFKLEDIQRKIEGLKRIEQMLMDLKERCPENKDI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YECPIIETLMKK
CCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]