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The map label for this gene is hmuU [H]

Identifier: 218905563

GI number: 218905563

Start: 4203906

End: 4204934

Strand: Reverse

Name: hmuU [H]

Synonym: BCAH820_4448

Alternate gene names: 218905563

Gene position: 4204934-4203906 (Counterclockwise)

Preceding gene: 218905564

Following gene: 218905562

Centisome position: 79.3

GC content: 39.75

Gene sequence:

>1029_bases
ATGGAAAGTAGTGAAGTAGTAAGGGAAGAGGAACATCCTTTTGCGAAAAAAAGATGGATCATAGCAGTTAGTTTAGTTAT
ATTAACGATTTTAGGTCTTTTTTACGGCCTTTTCGCAGGAAGCTTATCCTTTTCTTTACGAGATATTCTAACAGGGATAC
AAGATGAAGGGTCGACAGTTCATCGAATTGTATGGGACCTTCGTATACCAAGAGTGCTCGTTGGATTTATAGTAGGAACA
TGTTTAGCTGCATCAGGTGCATTATTACAAGGAGTTATGAGAAACCCTCTTGCAGACCCCGGTATTATTGGGGTTTCATC
TGGAGCAGGCCTTGTAGCAATCGTAATTATGATTTTATTCCCTCAGCATATGGCTTTTTTACCGCTCGGGGCGTTTTTAG
GAGCTTTCATAACGGCGATGATCATTTATGCTTTATCATGGCAAAAAGGGGCGCCACCTTCAAGAATTGTCTTAGTAGGC
GTGTCAATCAATGCATTAATTGGTGCAGCAACATCAGCGTTAATGTTATTGCATAGTGACAAAGTACAGTCCGTGTTACC
GTGGTTAGCAGGTGGCATTGGTGGTGTGAGCTGGGCACATTTAAACATGATTATTTATTATGCAATATTCGCTATTATAT
TGGCTTTCTTTGGTATCAAGCATATTCGAGTATTAATGCTTGGAGATGAAATGGCGAAATTATTGGGGCATAACGTGGAG
AGAAGCCGGTTTTATTTAATAGTAGTAAGTACATTATTAGCTGGAATTGCGGTGAGTGTTTCTGGTCTTATTGGATTTGT
CGGTCTCGTCGTACCACATATGTTACGTTTATTAGTTGGGAATGACTATAAATATTTACTGCCATTATCATGCCTTGGCG
GAGGAATATTACTTGTTTTCGCAGATGCGATAGCTCGAAGTTGGTTCGATCCAATTGAATTACCTGTCGGTATTTTATTA
TCCTTCTTAGGCGGTCCGTTCTTCTTATATTTAATTCATAGGGGAGGCAAGCAACGTGATTTCCGTTAA

Upstream 100 bases:

>100_bases
TTTTGCCACCTGACTTATTTGGATCAAATCCTGGAACAAAAGTTACAGAAGCGATGGACTTTATGTATAAAAGTATACAA
TATGTAAGGAAATGATAAGT

Downstream 100 bases:

>100_bases
CAAAGTGTTTTACGCACATTCTGAAAGATTTCAAATGCAAAATATGAATGTACATATTAAAGCTGGAGAGGTCGTTAGTT
TAATTGGACCGAATGGGTCA

Product: iron compound ABC transporter, permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MESSEVVREEEHPFAKKRWIIAVSLVILTILGLFYGLFAGSLSFSLRDILTGIQDEGSTVHRIVWDLRIPRVLVGFIVGT
CLAASGALLQGVMRNPLADPGIIGVSSGAGLVAIVIMILFPQHMAFLPLGAFLGAFITAMIIYALSWQKGAPPSRIVLVG
VSINALIGAATSALMLLHSDKVQSVLPWLAGGIGGVSWAHLNMIIYYAIFAIILAFFGIKHIRVLMLGDEMAKLLGHNVE
RSRFYLIVVSTLLAGIAVSVSGLIGFVGLVVPHMLRLLVGNDYKYLLPLSCLGGGILLVFADAIARSWFDPIELPVGILL
SFLGGPFFLYLIHRGGKQRDFR

Sequences:

>Translated_342_residues
MESSEVVREEEHPFAKKRWIIAVSLVILTILGLFYGLFAGSLSFSLRDILTGIQDEGSTVHRIVWDLRIPRVLVGFIVGT
CLAASGALLQGVMRNPLADPGIIGVSSGAGLVAIVIMILFPQHMAFLPLGAFLGAFITAMIIYALSWQKGAPPSRIVLVG
VSINALIGAATSALMLLHSDKVQSVLPWLAGGIGGVSWAHLNMIIYYAIFAIILAFFGIKHIRVLMLGDEMAKLLGHNVE
RSRFYLIVVSTLLAGIAVSVSGLIGFVGLVVPHMLRLLVGNDYKYLLPLSCLGGGILLVFADAIARSWFDPIELPVGILL
SFLGGPFFLYLIHRGGKQRDFR
>Mature_342_residues
MESSEVVREEEHPFAKKRWIIAVSLVILTILGLFYGLFAGSLSFSLRDILTGIQDEGSTVHRIVWDLRIPRVLVGFIVGT
CLAASGALLQGVMRNPLADPGIIGVSSGAGLVAIVIMILFPQHMAFLPLGAFLGAFITAMIIYALSWQKGAPPSRIVLVG
VSINALIGAATSALMLLHSDKVQSVLPWLAGGIGGVSWAHLNMIIYYAIFAIILAFFGIKHIRVLMLGDEMAKLLGHNVE
RSRFYLIVVSTLLAGIAVSVSGLIGFVGLVVPHMLRLLVGNDYKYLLPLSCLGGGILLVFADAIARSWFDPIELPVGILL
SFLGGPFFLYLIHRGGKQRDFR

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=319, Percent_Identity=35.1097178683386, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786804, Length=327, Percent_Identity=29.9694189602446, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790741, Length=318, Percent_Identity=31.1320754716981, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788004, Length=277, Percent_Identity=34.2960288808664, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786805, Length=275, Percent_Identity=35.6363636363636, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786347, Length=279, Percent_Identity=30.1075268817204, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36916; Mature: 36916

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESSEVVREEEHPFAKKRWIIAVSLVILTILGLFYGLFAGSLSFSLRDILTGIQDEGSTV
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
HRIVWDLRIPRVLVGFIVGTCLAASGALLQGVMRNPLADPGIIGVSSGAGLVAIVIMILF
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
PQHMAFLPLGAFLGAFITAMIIYALSWQKGAPPSRIVLVGVSINALIGAATSALMLLHSD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
KVQSVLPWLAGGIGGVSWAHLNMIIYYAIFAIILAFFGIKHIRVLMLGDEMAKLLGHNVE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
RSRFYLIVVSTLLAGIAVSVSGLIGFVGLVVPHMLRLLVGNDYKYLLPLSCLGGGILLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCHHHHHH
ADAIARSWFDPIELPVGILLSFLGGPFFLYLIHRGGKQRDFR
HHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MESSEVVREEEHPFAKKRWIIAVSLVILTILGLFYGLFAGSLSFSLRDILTGIQDEGSTV
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
HRIVWDLRIPRVLVGFIVGTCLAASGALLQGVMRNPLADPGIIGVSSGAGLVAIVIMILF
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
PQHMAFLPLGAFLGAFITAMIIYALSWQKGAPPSRIVLVGVSINALIGAATSALMLLHSD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
KVQSVLPWLAGGIGGVSWAHLNMIIYYAIFAIILAFFGIKHIRVLMLGDEMAKLLGHNVE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
RSRFYLIVVSTLLAGIAVSVSGLIGFVGLVVPHMLRLLVGNDYKYLLPLSCLGGGILLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCHHHHHH
ADAIARSWFDPIELPVGILLSFLGGPFFLYLIHRGGKQRDFR
HHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]