Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 218905462

GI number: 218905462

Start: 4130374

End: 4132338

Strand: Reverse

Name: comEC [H]

Synonym: BCAH820_4347

Alternate gene names: 218905462

Gene position: 4132338-4130374 (Counterclockwise)

Preceding gene: 218905463

Following gene: 218905460

Centisome position: 77.93

GC content: 35.93

Gene sequence:

>1965_bases
ATGCGACAATTACATGCAGGAGTGTCATGTATATTTGATGGTGAGAGGAAAGAACCACAAATAGCTCGGAATTTTCATGG
GTTTAATTATCGTGATTATTTATATAAGCAAAATATTCATTTCATATTGGAAGCTACATATATTTCTGAATGCCGTAAAA
CATCGTTGTCACTTGTGCAATGGATTCTTCTTTTGAGGCAGCAAGCAATCTTAGGAGTTACAGAAATGTTTCCAGAGCAA
TCAGGCGCTTTTATGAACGCGTTACTATTTGGTGATAGACAACAAATGACATTTGAAGTTGAAGGGCAATATCAACAATT
CGGTCTTGTGCATTTGTTGGCGATTTCAGGATCGCATATCGTATTGTTAGTGGTGATTGTGTATTTTATTTTGCTAAGAA
GTGGTGTGACAAGGGAGATAGCAACAGTATGTCTTATCTTCTTCATTCCTATATATATGATTTTAGCAGGAGCGTCACCG
TCTGTTATAAGAGCTTCTATAACAGGAGTTTTAATGTTAATTGCTTTTATGTGTTCTATTCGTTTATCTAGCTTAGATGC
TTTAAGTATAACAGCTATATGTATGCTTATATTTGATCCATATCTCGTGTTTAATATTGGCTTTCAGTTTTCTTTCGTTG
GGAGTTTTGCTTTACTTTTATCTGCCCCGCTCTTACTAGAGAGTGGTAATGGAGTAATTAGAAATTCTATTTATATTTCT
CTTATTTCACAGCTCGTTAGTACTCCGATTTTGTTATATCACTTCGGTTATTATTCTCCATATAGTATTTTTCTAAATAT
CCTTTACGTTCCGTTTTTATCTCTCATTGTATTGCCGTGTAGTATTATTATTTTGATATGTTTGCCGATCATCCCGTTTC
TTGCAAAAAGCTTTGCGAATGTACTATCAATAGGTTTGAATCTTTCTAATGATTTTTTAAGTTATTGTGAAAGTTTACCA
TTTACCCGTCTTAATTTCGGGCAAACACCTATACTTCTTGTAGCCTTATATTGCGTGAGTATTATTAGTGTATTGATGGT
TTGGGAAAGGCGAATATCTAAGGGAATGGTGTTTATATTTGCGGGCATATTTCTTTTTATTAGTACAGGTCATTATGTAT
ATCCGTATTTTCGAGAAAGTGGGAGTGTTACATTTCTTGATGTTGGCCAGGGGGATGCAATATTAATTCGCCTCCCGTAT
GATCAAGAGATTTACCTTATTGACACTGGTGGAACAATTCGTTTAAACAAGGAAGAATGGCAACGGAAAAAACATGAATT
TTCTGTTGGAAATGATATTTTGATCCCTTATTTACAAAAGGAAGGTATTAAAAAAATTGATAAATTAATTGTAACGCATG
GAGATGCAGATCATATCGGTGCTGCACAAGAATTATTATCAAATATAACCGTAAAAGAAGTTGTATTTGGTCGAAAGGAA
CAAGAGGCAATATTAGAAAAAGCAGTAAAGAAACAGGCGTTAGAAAAGGAAGTGAAAATAAGTGAAGTGGGGGAAGGAGA
GAGTTGGCGCGTAAATGAAGCGGAATTTTTTGTGCTAGCACCAACAGGGAAAGAAAGAAGTGAAAATAACGCTTCAATTG
TACTGTGGGCAAAATTAGGAGGGATAACGTGGCTGTTTACAGGTGATTTAGAAGAAGAAGGAGAGAAGGGTTTAGTAGCT
ACATATCCAGATTTACGGGCGGATGTTTTAAAGGTTGCTCATCATGGAAGTAATACGTCATCTATAACGCCTTTTTTGAG
CGCCGTACAGCCTAATATAGCGATTATTTCTGTCGGTGAACGGAATAGGTATGGGCACCCTCATAAGGAAGTTATAGAGC
GTTTTGAGAAGATGGCGATTGAAATATGGCGCACGGATAAGCAAGGTGCTATTTCCTATGTTTTTAAAGAGGAACGCGGA
ACGTTTCGTAGCAAAATCACATATGATGAAACACGGAATAGATAA

Upstream 100 bases:

>100_bases
TCTTATTAACGGGGATCGCCTATCATTTCAAGTTGAAGATCAGAATAAAAATATAGTGCAGTTAAGTTACAAAATGAAAT
CAGCCTCGGAAAAGAGACAA

Downstream 100 bases:

>100_bases
AAAAAAGACTGCTAGTAAGCAGCAGTCTTTAAGAACCGATAAATTTAATAACAGTTGCAATGATGAAAAGTGTTGCGAAA
AAACCAAATGAGACGATAAA

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MRQLHAGVSCIFDGERKEPQIARNFHGFNYRDYLYKQNIHFILEATYISECRKTSLSLVQWILLLRQQAILGVTEMFPEQ
SGAFMNALLFGDRQQMTFEVEGQYQQFGLVHLLAISGSHIVLLVVIVYFILLRSGVTREIATVCLIFFIPIYMILAGASP
SVIRASITGVLMLIAFMCSIRLSSLDALSITAICMLIFDPYLVFNIGFQFSFVGSFALLLSAPLLLESGNGVIRNSIYIS
LISQLVSTPILLYHFGYYSPYSIFLNILYVPFLSLIVLPCSIIILICLPIIPFLAKSFANVLSIGLNLSNDFLSYCESLP
FTRLNFGQTPILLVALYCVSIISVLMVWERRISKGMVFIFAGIFLFISTGHYVYPYFRESGSVTFLDVGQGDAILIRLPY
DQEIYLIDTGGTIRLNKEEWQRKKHEFSVGNDILIPYLQKEGIKKIDKLIVTHGDADHIGAAQELLSNITVKEVVFGRKE
QEAILEKAVKKQALEKEVKISEVGEGESWRVNEAEFFVLAPTGKERSENNASIVLWAKLGGITWLFTGDLEEEGEKGLVA
TYPDLRADVLKVAHHGSNTSSITPFLSAVQPNIAIISVGERNRYGHPHKEVIERFEKMAIEIWRTDKQGAISYVFKEERG
TFRSKITYDETRNR

Sequences:

>Translated_654_residues
MRQLHAGVSCIFDGERKEPQIARNFHGFNYRDYLYKQNIHFILEATYISECRKTSLSLVQWILLLRQQAILGVTEMFPEQ
SGAFMNALLFGDRQQMTFEVEGQYQQFGLVHLLAISGSHIVLLVVIVYFILLRSGVTREIATVCLIFFIPIYMILAGASP
SVIRASITGVLMLIAFMCSIRLSSLDALSITAICMLIFDPYLVFNIGFQFSFVGSFALLLSAPLLLESGNGVIRNSIYIS
LISQLVSTPILLYHFGYYSPYSIFLNILYVPFLSLIVLPCSIIILICLPIIPFLAKSFANVLSIGLNLSNDFLSYCESLP
FTRLNFGQTPILLVALYCVSIISVLMVWERRISKGMVFIFAGIFLFISTGHYVYPYFRESGSVTFLDVGQGDAILIRLPY
DQEIYLIDTGGTIRLNKEEWQRKKHEFSVGNDILIPYLQKEGIKKIDKLIVTHGDADHIGAAQELLSNITVKEVVFGRKE
QEAILEKAVKKQALEKEVKISEVGEGESWRVNEAEFFVLAPTGKERSENNASIVLWAKLGGITWLFTGDLEEEGEKGLVA
TYPDLRADVLKVAHHGSNTSSITPFLSAVQPNIAIISVGERNRYGHPHKEVIERFEKMAIEIWRTDKQGAISYVFKEERG
TFRSKITYDETRNR
>Mature_654_residues
MRQLHAGVSCIFDGERKEPQIARNFHGFNYRDYLYKQNIHFILEATYISECRKTSLSLVQWILLLRQQAILGVTEMFPEQ
SGAFMNALLFGDRQQMTFEVEGQYQQFGLVHLLAISGSHIVLLVVIVYFILLRSGVTREIATVCLIFFIPIYMILAGASP
SVIRASITGVLMLIAFMCSIRLSSLDALSITAICMLIFDPYLVFNIGFQFSFVGSFALLLSAPLLLESGNGVIRNSIYIS
LISQLVSTPILLYHFGYYSPYSIFLNILYVPFLSLIVLPCSIIILICLPIIPFLAKSFANVLSIGLNLSNDFLSYCESLP
FTRLNFGQTPILLVALYCVSIISVLMVWERRISKGMVFIFAGIFLFISTGHYVYPYFRESGSVTFLDVGQGDAILIRLPY
DQEIYLIDTGGTIRLNKEEWQRKKHEFSVGNDILIPYLQKEGIKKIDKLIVTHGDADHIGAAQELLSNITVKEVVFGRKE
QEAILEKAVKKQALEKEVKISEVGEGESWRVNEAEFFVLAPTGKERSENNASIVLWAKLGGITWLFTGDLEEEGEKGLVA
TYPDLRADVLKVAHHGSNTSSITPFLSAVQPNIAIISVGERNRYGHPHKEVIERFEKMAIEIWRTDKQGAISYVFKEERG
TFRSKITYDETRNR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=601, Percent_Identity=22.2961730449251, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 73805; Mature: 73805

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQLHAGVSCIFDGERKEPQIARNFHGFNYRDYLYKQNIHFILEATYISECRKTSLSLVQ
CCCHHCCCEEEECCCCCCCHHHHHCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
WILLLRQQAILGVTEMFPEQSGAFMNALLFGDRQQMTFEVEGQYQQFGLVHLLAISGSHI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHCCEEEEEECCCHH
VLLVVIVYFILLRSGVTREIATVCLIFFIPIYMILAGASPSVIRASITGVLMLIAFMCSI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
RLSSLDALSITAICMLIFDPYLVFNIGFQFSFVGSFALLLSAPLLLESGNGVIRNSIYIS
HHHCCCHHHHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHHCCCEEECCCCEEHHHHHHH
LISQLVSTPILLYHFGYYSPYSIFLNILYVPFLSLIVLPCSIIILICLPIIPFLAKSFAN
HHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLSIGLNLSNDFLSYCESLPFTRLNFGQTPILLVALYCVSIISVLMVWERRISKGMVFIF
HHHHCCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AGIFLFISTGHYVYPYFRESGSVTFLDVGQGDAILIRLPYDQEIYLIDTGGTIRLNKEEW
HHHHHHHHCCCEEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEEECCCEEEECHHHH
QRKKHEFSVGNDILIPYLQKEGIKKIDKLIVTHGDADHIGAAQELLSNITVKEVVFGRKE
HHHHHCCCCCCCEEEHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHHHCCCH
QEAILEKAVKKQALEKEVKISEVGEGESWRVNEAEFFVLAPTGKERSENNASIVLWAKLG
HHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECCCEEEEECCCCCCCCCCCCEEEEEEEEC
GITWLFTGDLEEEGEKGLVATYPDLRADVLKVAHHGSNTSSITPFLSAVQPNIAIISVGE
CEEEEEECCCHHCCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECC
RNRYGHPHKEVIERFEKMAIEIWRTDKQGAISYVFKEERGTFRSKITYDETRNR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHCEECHHCCCC
>Mature Secondary Structure
MRQLHAGVSCIFDGERKEPQIARNFHGFNYRDYLYKQNIHFILEATYISECRKTSLSLVQ
CCCHHCCCEEEECCCCCCCHHHHHCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
WILLLRQQAILGVTEMFPEQSGAFMNALLFGDRQQMTFEVEGQYQQFGLVHLLAISGSHI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHCCEEEEEECCCHH
VLLVVIVYFILLRSGVTREIATVCLIFFIPIYMILAGASPSVIRASITGVLMLIAFMCSI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
RLSSLDALSITAICMLIFDPYLVFNIGFQFSFVGSFALLLSAPLLLESGNGVIRNSIYIS
HHHCCCHHHHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHHCCCEEECCCCEEHHHHHHH
LISQLVSTPILLYHFGYYSPYSIFLNILYVPFLSLIVLPCSIIILICLPIIPFLAKSFAN
HHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLSIGLNLSNDFLSYCESLPFTRLNFGQTPILLVALYCVSIISVLMVWERRISKGMVFIF
HHHHCCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AGIFLFISTGHYVYPYFRESGSVTFLDVGQGDAILIRLPYDQEIYLIDTGGTIRLNKEEW
HHHHHHHHCCCEEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEEECCCEEEECHHHH
QRKKHEFSVGNDILIPYLQKEGIKKIDKLIVTHGDADHIGAAQELLSNITVKEVVFGRKE
HHHHHCCCCCCCEEEHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHHHCCCH
QEAILEKAVKKQALEKEVKISEVGEGESWRVNEAEFFVLAPTGKERSENNASIVLWAKLG
HHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECCCEEEEECCCCCCCCCCCCEEEEEEEEC
GITWLFTGDLEEEGEKGLVATYPDLRADVLKVAHHGSNTSSITPFLSAVQPNIAIISVGE
CEEEEEECCCHHCCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECC
RNRYGHPHKEVIERFEKMAIEIWRTDKQGAISYVFKEERGTFRSKITYDETRNR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHCEECHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]