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The map label for this gene is hemN [H]

Identifier: 218905454

GI number: 218905454

Start: 4123132

End: 4124268

Strand: Reverse

Name: hemN [H]

Synonym: BCAH820_4339

Alternate gene names: 218905454

Gene position: 4124268-4123132 (Counterclockwise)

Preceding gene: 218905455

Following gene: 218905453

Centisome position: 77.78

GC content: 36.32

Gene sequence:

>1137_bases
GTGCAAGCTGCATATATTCATATTCCGTTTTGTCAGCATATTTGTCACTATTGTGATTTTAATAAAGTGTTTATTGAACG
CCAGCCGGTGGATCAATATTTAGAGTATTTAGAGAAAGAAATAATAAATACAGTTCAAAAGGTATCGTTTGATAGTATGA
AAACGATTTTTGTTGGCGGGGGAACTCCGACAGCATTAAATATGGAGCAGACAAAGAAATTATTAGATATAATAAATCGT
CGTTTACGTCCGTTTGCCCCGAATTGTGAATTAACATTTGAAGCGAATCCAGGTGATTTGCCGAAAGAGAAATTAAATGT
ATTGCTAGAGGGTGGAGTGAACCGAATTAGTTTTGGTGTGCAAACATTTCGAGATGAACTGCTTGAGAAAATTGGGCGTA
AGCATACGAGAGAAGATGCGTTTGTAGCAATTAGAGAAGCGCAGGAAGTGGGCTTCAAAAATATAAATGTAGATATTATT
TACGCTCTGCCAGGGCAGACGATAGAAGATGTGAAAGAAACGTTAGATATTGCTTTTACGCTTGGTGTACAACATTTCTC
GGCATATTCATTAATTGTGGAACCGAAAACTGTGTTTTATAACTTAATGAATAAAGGGAAATTAAGACTTCCAGGGGAAG
ACCATGAAGCGAAAATGTATGAAATGGTAATGGATGAAATGGAGAGACACGGCTATACCCAGTATGAAATTAGTAATTTT
TCAAAAGGTGATAATGAAAGTAGGCATAATCTCACATACTGGAATAATGAAGAGTATTATGGGTTTGGAGCTGGAGCGCA
TAGTTATGTAAATGGAGAACGTATCCAAAATGTAGGACCGCTCAAACAATATTTCAATAAAATCGATGAAACCGGGTTTC
CGTATTTAGATGTTCATGTGGTGACGGAGAAAGAAAAAATGGAAGAAGAGTTGTTCTTAGGTCTTCGTAAAACAAAAGGT
GTGTCAAAAATGGCGTTCCGCAATAAATTTAATGTGGAAATGAATCAAGTTTTCGCGAAGCAGTTACAAAACAACCAAGA
ACAAGGATTGCTTGAAGAGAGCGATGGATATGTTCGTTTAACGCGAAAAGGGAAATTATTAGGGAATGAAGTATTCCAAT
CATTTTTGATTGACTAA

Upstream 100 bases:

>100_bases
GGAAAAATGCGAATGGAACAAATTCGTAATACGTTAGAGAAGTAAAAGAAGCCTCCCGAGCGCGGAGGTTTTCTTTTTAG
AAAGGTAGGAGTTATTTTTG

Downstream 100 bases:

>100_bases
TTACATGTTCCATGAACGTGAAAAAGTTTCATTATTTCGTGACGTTTCCGTTGACAATTGAATGTCAATTTTGGTAAGTT
ATTAATAGATTTAGCACTCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVSFDSMKTIFVGGGTPTALNMEQTKKLLDIINR
RLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGVQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDII
YALPGQTIEDVKETLDIAFTLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISNF
SKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHVVTEKEKMEEELFLGLRKTKG
VSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRLTRKGKLLGNEVFQSFLID

Sequences:

>Translated_378_residues
MQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVSFDSMKTIFVGGGTPTALNMEQTKKLLDIINR
RLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGVQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDII
YALPGQTIEDVKETLDIAFTLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISNF
SKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHVVTEKEKMEEELFLGLRKTKG
VSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRLTRKGKLLGNEVFQSFLID
>Mature_378_residues
MQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVSFDSMKTIFVGGGTPTALNMEQTKKLLDIINR
RLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGVQTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDII
YALPGQTIEDVKETLDIAFTLGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISNF
SKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHVVTEKEKMEEELFLGLRKTKG
VSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRLTRKGKLLGNEVFQSFLID

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=30.9433962264151, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1789325, Length=379, Percent_Identity=33.245382585752, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI87082341, Length=387, Percent_Identity=26.8733850129199, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43755; Mature: 43755

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVSFDSMKTIFVGG
CCEEEEECHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GTPTALNMEQTKKLLDIINRRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGV
CCCCEECHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHH
QTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDIIYALPGQTIEDVKETLDIAFT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
LGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISNF
HHHHHHCEEEEEECHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECCC
SKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHV
CCCCCCCCCCCEEECCCCEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCEEEEEE
VTEKEKMEEELFLGLRKTKGVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRL
ECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHCCCEECCCCEEEE
TRKGKLLGNEVFQSFLID
EECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQAAYIHIPFCQHICHYCDFNKVFIERQPVDQYLEYLEKEIINTVQKVSFDSMKTIFVGG
CCEEEEECHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GTPTALNMEQTKKLLDIINRRLRPFAPNCELTFEANPGDLPKEKLNVLLEGGVNRISFGV
CCCCEECHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHH
QTFRDELLEKIGRKHTREDAFVAIREAQEVGFKNINVDIIYALPGQTIEDVKETLDIAFT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
LGVQHFSAYSLIVEPKTVFYNLMNKGKLRLPGEDHEAKMYEMVMDEMERHGYTQYEISNF
HHHHHHCEEEEEECHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECCC
SKGDNESRHNLTYWNNEEYYGFGAGAHSYVNGERIQNVGPLKQYFNKIDETGFPYLDVHV
CCCCCCCCCCCEEECCCCEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCEEEEEE
VTEKEKMEEELFLGLRKTKGVSKMAFRNKFNVEMNQVFAKQLQNNQEQGLLEESDGYVRL
ECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCHHCCCEECCCCEEEE
TRKGKLLGNEVFQSFLID
EECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]