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The map label for this gene is cidA2

Identifier: 218904882

GI number: 218904882

Start: 3592936

End: 3593292

Strand: Reverse

Name: cidA2

Synonym: BCAH820_3766

Alternate gene names: 218904882

Gene position: 3593292-3592936 (Counterclockwise)

Preceding gene: 218904883

Following gene: 218904881

Centisome position: 67.76

GC content: 34.45

Gene sequence:

>357_bases
ATGAAGTACGTGATGCTTTTACTTCAAGTAGGCGTGCTGTATGTATTTAGTTTAGTTGGTACGTGGATTCAAGGAGTATT
CCATTTATCAATGCCAGGAAGTTTAATAGGAATGTTAATGCTGTTTCTGCTCCTTTCCACTCGTATTTTACCATTAAAGT
GGTTTGAAGAAGGTGCGGAAAAGTTACTCGTATTTTTACCGTTATTTCTTATTCCTTCGACAACAGGCTTGATGGAATAC
GAGTCTTTTCTTTTCAGTAAGGGGAGTATTATATTCCTTTTAGTAGTTATAAGCACGGTAGTAACTTTGATTGTTTCAGG
GTATATAAGTCAATTGTTAGTAACATCAAAAAAATAA

Upstream 100 bases:

>100_bases
AGTAAATGCCGAACAAATTCAGCTGGGAATGACGAGGTTTGCTGAAACGTTAAATGAGATTTCATAATAGTGATACGTAA
TATTGAAATGAGGGAAAGAA

Downstream 100 bases:

>100_bases
AATCGACAAGGTGCACGATGCAAATGGTCTTCATTATTATTACTGTAGTAGTTTATTTATTGGCGACAAAGTTATATAAA
AAATTTACGTTTCCATTTAC

Product: holin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MKYVMLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLMLFLLLSTRILPLKWFEEGAEKLLVFLPLFLIPSTTGLMEY
ESFLFSKGSIIFLLVVISTVVTLIVSGYISQLLVTSKK

Sequences:

>Translated_118_residues
MKYVMLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLMLFLLLSTRILPLKWFEEGAEKLLVFLPLFLIPSTTGLMEY
ESFLFSKGSIIFLLVVISTVVTLIVSGYISQLLVTSKK
>Mature_118_residues
MKYVMLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLMLFLLLSTRILPLKWFEEGAEKLLVFLPLFLIPSTTGLMEY
ESFLFSKGSIIFLLVVISTVVTLIVSGYISQLLVTSKK

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily

Homologues:

Organism=Escherichia coli, GI1788463, Length=106, Percent_Identity=33.0188679245283, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CIDA2_BACAN (Q81WT3)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846132.1
- RefSeq:   YP_020523.1
- RefSeq:   YP_029852.1
- IntAct:   Q81WT3
- EnsemblBacteria:   EBBACT00000011898
- EnsemblBacteria:   EBBACT00000015318
- EnsemblBacteria:   EBBACT00000023257
- GeneID:   1087660
- GeneID:   2815104
- GeneID:   2851082
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_3885
- KEGG:   bar:GBAA_3885
- KEGG:   bat:BAS3599
- TIGR:   BA_3885
- TIGR:   GBAA_3885
- GeneTree:   EBGT00050000000864
- HOGENOM:   HBG697118
- OMA:   MEYGSFL
- ProtClustDB:   PRK01658
- BioCyc:   BANT260799:BAS3599-MONOMER
- BioCyc:   BANT261594:GBAA3885-MONOMER
- GO:   GO:0019835
- HAMAP:   MF_01143
- InterPro:   IPR005538

Pfam domain/function: PF03788 LrgA

EC number: NA

Molecular weight: Translated: 13222; Mature: 13222

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e3da9f8)-; HASH(0x1f093864)-; HASH(0x1ed0a26c)-; HASH(0x18a6b7f4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVMLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLMLFLLLSTRILPLKWFEEGAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KLLVFLPLFLIPSTTGLMEYESFLFSKGSIIFLLVVISTVVTLIVSGYISQLLVTSKK
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKYVMLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLMLFLLLSTRILPLKWFEEGAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KLLVFLPLFLIPSTTGLMEYESFLFSKGSIIFLLVVISTVVTLIVSGYISQLLVTSKK
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629