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The map label for this gene is moeA2 [H]

Identifier: 218904690

GI number: 218904690

Start: 3407016

End: 3408323

Strand: Reverse

Name: moeA2 [H]

Synonym: BCAH820_3574

Alternate gene names: 218904690

Gene position: 3408323-3407016 (Counterclockwise)

Preceding gene: 218904691

Following gene: 218904689

Centisome position: 64.28

GC content: 39.14

Gene sequence:

>1308_bases
ATGGAAAGAAGAGTGCCAATTACGGTTGAAGAAGCTGTTCGTAAAGTAATGGAATTTGCTAATGAGGGTTTAAAGGAGCT
ACTACCTATTGAATTAGCTTACGGACGTGTATTAGCGGAGAATTTAGTAGCTGACCATGACGTACCTTCATTCAATCGTT
CACCGTATGACGGATTTGCTATTAGAGCAGAAGATACGAATTTAGCAAGTTATGAAACGCCAATTGTATTTGAAGTAGTG
GGTGAAATTGGTGCAGGATCGCTATTCGATGAGAAAGTAGGTCCGTTTCAAGCAGTTCGAATTATGACGGGAGCGCAAAT
TCCGAATGGATGTGATGCAGTTGTTATGCTAGAGCTGACTCGTCAATATGAGGAGGCTGGCAGTAAGTATATGGAATTGA
AGCGGTCATTCAAAGCGGGCGATAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACGGTTCTTGCAAAGAAAGGA
ACATACATTAATCCAGGTATTTCAGCTCTTCTTGCTACATTCGGGTATAGCGAGGTGCCAGTTGCGAGAAAGCCTGTAGT
TGGACTATTAGCGACTGGCAGTGAATTACTGGATGTAAACGATTCATTACAGCCAGGGAAAATCCGAAATAGTAATACGT
ATATGATATTGTCTCAAATCCGAAGAGCAGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGATGATTTTCATACGTGT
TTTACGGCTGTAAAAGAAGCATTAAGCCAAGTAGATATGCTCATTACAACAGGTGGTGTATCAGTAGGGGATTACGATTA
TTTGCCAGCTATATATGAAAAATTAGGTGCATCAGTTCTTTTCAATAAAGTTGCAATGCGGCCAGGAAGTGTAACGACTG
TAGCGCAATTAAATGGAAAGTTATTATTTGGTTTATCAGGAAATCCATCTGCTTGTTACGTAGGGTTTGAATTGTTTGTA
AGACCTTGTATTCGGACGTATATGTTTAGTGAAAAAGCACATGTAAAAAGAGAAAAAGCGTTATTAGGAGAAGACTTTTT
AAAGCCAAATCCATTTACAAGGTTTGTACGAGGAAAACTAACATATAACGAAGGGCAGTTAATCGCTTATCCGTCAGGGT
TTGATAAATCTAGCTCAGTTTCCTCTCTAGCGGAGACAAATATATTTATTGTACTTCCAGGTGGTACGAGAGGTTATAAA
AAAGATATGTTCGTAGATGTGCTCTTGTTGGAAGATAACGAAGGTAGTGAATGGCCTTGGACATTTTATAAAGTGAGAGG
TGATTCTAATGGGACAAGTGCTATTTGA

Upstream 100 bases:

>100_bases
TTTTCGAGATGGTCGTGTTTTCATTCATGGTACAAATGATATTTTAAAAGCAAAACAGTTATATTATCGCGTATTCGGTT
AATAGAAAGGGTTGTCAATA

Downstream 100 bases:

>100_bases
AATTGTAGATATACCGATTGTAGTTGAAGAAGTAACGAATAAGGTTGCAAGAAGAGAAGCAGGTGCGATTACAACTTTTA
TTGGTACAGTGAGAGAATTA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAENLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Sequences:

>Translated_435_residues
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAENLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI
>Mature_435_residues
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAENLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=420, Percent_Identity=34.2857142857143, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI10880983, Length=420, Percent_Identity=34.2857142857143, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=34.8648648648649, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=398, Percent_Identity=28.894472361809, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=393, Percent_Identity=27.4809160305344, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136978, Length=360, Percent_Identity=29.1666666666667, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=360, Percent_Identity=29.1666666666667, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47816; Mature: 47816

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAENLVADHDVPSFNRSPYDGFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCCEEHHHHH
RQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC
>Mature Secondary Structure
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAENLVADHDVPSFNRSPYDGFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCCEEHHHHH
RQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]