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The map label for this gene is csgA [H]

Identifier: 218904553

GI number: 218904553

Start: 3274032

End: 3274736

Strand: Reverse

Name: csgA [H]

Synonym: BCAH820_3437

Alternate gene names: 218904553

Gene position: 3274736-3274032 (Counterclockwise)

Preceding gene: 218904554

Following gene: 218904552

Centisome position: 61.76

GC content: 36.45

Gene sequence:

>705_bases
ATGAGAGTTCTAATTACAGGTGGAAATCGCGGATTAGGGTTGCAGTTAGTAAAAGTATTTCATGAAAATGGGCATATTAT
TTATCCGTTAGTTAGAACTGAGGTTGCGGTAACGCAATTGAAGCAAATGTTTAGTTGTAGATGTTTTCCTATATTAGCAG
ACTTAGCGGCTGATGAGAGTACAGAGCAAATTAAGAAACAGCTTGAGGAATATACAGAGTATATTGATCTAGTTATAAAT
AACGCTGGAATTACTGGAAAGGAGACTGAGGTTTTACATACGAATTCAGAAGAGTTAACGGACTTATTTAATATTCATTG
CTTAGGTGTAATTCGAGCTGTAAAAGGTACATATATGGCTTTAGCTAAATCGGATCATCCGAGAATAATAAATGTGTCCT
CTCGGTTAGGTTCATTGCATAAAATGGCCAACAAAGAGTTTCCGCAAGGCCATTTCTCATATTCATATCGAATTGCTAAA
GCTGCACAAAATATGCTAACACTCTGCTTACAACAAGAGTTTGAGAATAAAGGAATAAGTGTAACTGCCATTCATCCTGG
AAAATTAAAGACTGAAATTGGTGCTTTTGATGCGAATATGACCCCGGCTGAAGGAGCAAAAAATATATATGATTGGGTAA
TAGATTCAAATGAGGATCTTTCAGGGCAGTTTATTGAGCCAGGTGTAGGTGAAATAAAGTGGTGA

Upstream 100 bases:

>100_bases
GAGCAGGTTTTTCTTTTGAATGCAAGAGAGAGGCGTTTTCTTTGGAGAATGGTGAGTGGATGGATTTTCTTATTTATTTT
AAAAATAAGGAGATGGATAT

Downstream 100 bases:

>100_bases
TATACGATCTTGCAATCATTCAGAATTTGTTTGGCCCTTCTAAAAAAGTATTAAATGACTTACCAAATGCAGTGACCATT
GAAGAAATAGAAGAAGACGT

Product: oxidoreductase, short chain dehydrogenase/reductase family

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYMALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDLSGQFIEPGVGEIKW

Sequences:

>Translated_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYMALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDLSGQFIEPGVGEIKW
>Mature_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYMALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDLSGQFIEPGVGEIKW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=23.1578947368421, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=227, Percent_Identity=29.5154185022026, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=219, Percent_Identity=26.9406392694064, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=198, Percent_Identity=28.7878787878788, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17558994, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=201, Percent_Identity=25.3731343283582, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=24.8, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26096; Mature: 26096

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
TEQIKKQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAKAAQNMLTLCLQQEFENKGIS
EECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDLSGQFIEPGVGEIKW
EEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHEECCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
TEQIKKQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAKAAQNMLTLCLQQEFENKGIS
EECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDLSGQFIEPGVGEIKW
EEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHEECCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]