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The map label for this gene is nprM [H]

Identifier: 218904524

GI number: 218904524

Start: 3248993

End: 3250690

Strand: Reverse

Name: nprM [H]

Synonym: BCAH820_3408

Alternate gene names: 218904524

Gene position: 3250690-3248993 (Counterclockwise)

Preceding gene: 218904525

Following gene: 218904523

Centisome position: 61.3

GC content: 34.75

Gene sequence:

>1698_bases
ATGAATAATTTCGTAAAGTTAGGTTTAACTACAGGAGTGGTGTTATCGGCGATTATTCCTTATGGAGGAGTATATGCGGC
AACAGAAGATTTAAAAGTGGAAACAAAGGAAGATACGTTCCGAACAGGTAATTTAACAGCACCTTCTCAAAAATCGGCAG
AAAATGTAGTAAAGGATGCGCTGAAAGGGAAAACAGAACAAGCATTATCCTCAAAGCAAGTTAACACGGAATCAAAAGTT
AATTATAATGTGACGCAAAGTCGTAAATCTTATGATGGTACTACATTGGTGCGTCTTCAACAAACATATGAAGGACGTGA
TGTATACGGATATCAACTAACAGCACATATTAATGATGATGGTGTACTTACGAGTATTTCGGGGGATAGTGCCCAAGATC
TACAACAACAGGAAGATTTGAAACAACCTATTATTCTATCAGAAGAGGATGCAAAGAAGCAGCTTTTTAAAATCTATGGG
GATAATCTCACATTTGTTGAAGAACCAGAAATTAAACAAGTGGTATATGTAGATGAAAATACAAATAAAGCTACAAACGC
ATATGAAATTACTTTTAGTGCCTCTACACCTGAATATGTATCTGGTACGGTATTAATTGATGCTTTTGTTGGAGATCTAT
TAAAAGAACTCGTTCAAAAATTGGGTGTACAAGTAGATAGCAGTATCGTTCAATCTGCAACAGCAAATAAATCACAAGAT
CCTTCGAAATTAATAGGCACAGGAAAAGATGATTTAGGTATGAATCGTACGTTTGGAATTTCACAGCGAAGTGATGGAAC
GTACACTCTTGCAGATTATTCTCGTGGTAAGGGAATTGAAACGTATACTGCGAATTATAAAGATTATAATAATTATAGAA
GAAATGTATGGGGATATTTGGATGATTTAGTAACAAGTAATTCTACAAATTTTACAGATCCTAAAGCAGTTAGTGCACAT
TATTTAGCAACGAAAGTATATGATTTTTATCAAGAAAAATATAGTCGTAACAGCTTTGATAATAATGGACAAAAAGTAAT
TTCAGTCGTTCATGGCTGGAATACAAATGGTAAGAATATAGGAAATCCTAAGCAGTGGTTTAATGCATTTAGTAATGGGG
CTATGCTAGTATACGGAGATCCAATTGTTAGAGCATTTGATGTGGCAGGACATGAGTTTACACACGCGGTTACAAGAAAT
GAGTCTGGACTTGAGTACGCAGGAGAAGCTGGTGCCATTAATGAGGCTCTATCTGATATTTTAGGGGTAGCAGTTGAAAA
GTATGCCAATAACGGAAAGTTCAATTGGACAATGGGGGAACAATCAGGTCGTATATTTAGAGATATGAAAAACCCATCAT
CTATCTCTTCTAGATATCCAGAAGATTATAGACATTATAACAATTTACCTATTGATGCTGATCACGATTATGGTGGTGTA
CACACGAACTCTAGCATTATAAATAAAGTAGCTTATTTAATTGCTAGTGGTGGAAATCATAATGGAGTAAATGTACAAGG
CATTGGGGAAGATAAAATGTTTGATATTTTCTATTATGCAAATACCGATGAATTAAATATGACTTCTGATTTTAAAGAAT
TAAAAGAAGCTTGTATTCGTGTAGCAACGAACTTATATGGTAAAGACTCATCAGAAGTACAAGCCGTCCAACAAGCCTTT
AAAGCAGCTTATATTTAA

Upstream 100 bases:

>100_bases
TATGCATGTAAAATTGATTGACTATAGTTAAATTATCTATGCTTAAAATTCTAAAGTACATTTATTTAATTTAATAATAC
GATTGTAAAGGAGTAAGAAT

Downstream 100 bases:

>100_bases
TACTATTGTGATGAATTGAAAACTCTCTTATTTTAATATAATGATTGGTTTGTATATGTAGGCAAAAACCTTGTAGAATT
TTTCTGCAAGGTTTTTTAGA

Product: bacillolysin

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MNNFVKLGLTTGVVLSAIIPYGGVYAATEDLKVETKEDTFRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKV
NYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQEDLKQPIILSEEDAKKQLFKIYG
DNLTFVEEPEIKQVVYVDENTNKATNAYEITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGVQVDSSIVQSATANKSQD
PSKLIGTGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAH
YLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRN
ESGLEYAGEAGAINEALSDILGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDSSEVQAVQQAF
KAAYI

Sequences:

>Translated_565_residues
MNNFVKLGLTTGVVLSAIIPYGGVYAATEDLKVETKEDTFRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKV
NYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQEDLKQPIILSEEDAKKQLFKIYG
DNLTFVEEPEIKQVVYVDENTNKATNAYEITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGVQVDSSIVQSATANKSQD
PSKLIGTGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAH
YLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRN
ESGLEYAGEAGAINEALSDILGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDSSEVQAVQQAF
KAAYI
>Mature_565_residues
MNNFVKLGLTTGVVLSAIIPYGGVYAATEDLKVETKEDTFRTGNLTAPSQKSAENVVKDALKGKTEQALSSKQVNTESKV
NYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSISGDSAQDLQQQEDLKQPIILSEEDAKKQLFKIYG
DNLTFVEEPEIKQVVYVDENTNKATNAYEITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGVQVDSSIVQSATANKSQD
PSKLIGTGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAH
YLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRN
ESGLEYAGEAGAINEALSDILGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDSSEVQAVQQAF
KAAYI

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 62590; Mature: 62590

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNFVKLGLTTGVVLSAIIPYGGVYAATEDLKVETKEDTFRTGNLTAPSQKSAENVVKDA
CCCEEEECHHHHHHHHHHHCCCCEEEECCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
LKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDD
HCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEEEEEECCC
GVLTSISGDSAQDLQQQEDLKQPIILSEEDAKKQLFKIYGDNLTFVEEPEIKQVVYVDEN
CEEEEECCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
TNKATNAYEITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGVQVDSSIVQSATANKSQD
CCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
PSKLIGTGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYL
CHHHHCCCCCCCCCCCEECCCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHH
DDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNI
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCC
GNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDI
CCHHHHHHHHCCCEEEEECCCHHEEHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HHHHHHHHCCCCEEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCE
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIR
ECCHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHH
VATNLYGKDSSEVQAVQQAFKAAYI
HHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNFVKLGLTTGVVLSAIIPYGGVYAATEDLKVETKEDTFRTGNLTAPSQKSAENVVKDA
CCCEEEECHHHHHHHHHHHCCCCEEEECCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
LKGKTEQALSSKQVNTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDD
HCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEEEEEECCC
GVLTSISGDSAQDLQQQEDLKQPIILSEEDAKKQLFKIYGDNLTFVEEPEIKQVVYVDEN
CEEEEECCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
TNKATNAYEITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGVQVDSSIVQSATANKSQD
CCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
PSKLIGTGKDDLGMNRTFGISQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYL
CHHHHCCCCCCCCCCCEECCCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHH
DDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNI
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCC
GNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDI
CCHHHHHHHHCCCEEEEECCCHHEEHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HHHHHHHHCCCCEEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCE
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIR
ECCHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHH
VATNLYGKDSSEVQAVQQAFKAAYI
HHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]