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The map label for this gene is dxr1 [H]

Identifier: 218904495

GI number: 218904495

Start: 3220437

End: 3221594

Strand: Direct

Name: dxr1 [H]

Synonym: BCAH820_3379

Alternate gene names: 218904495

Gene position: 3220437-3221594 (Clockwise)

Preceding gene: 218904488

Following gene: 218904498

Centisome position: 60.73

GC content: 36.01

Gene sequence:

>1158_bases
ATGGTAAAATATATATCCATTTTAGGTTCAACAGGATCCATCGGCACATCGGCATTAGATGTCGTTTCAGCTCATCCCGA
ACATTTTAAAATCGTCGGTTTAACCGCAAATTATAATATCGAGCTTCTTGAACAACAAATCAAAACGTTTCAACCTCGCA
TTGTAAGCGTCGCGACAAAAGAATTAGCAGACACGCTTCGTACGCGTATTTCAACCAACACAAAAATCACATACGGAACA
GATGGCTTAATTACAGTAGCTACTCACCCTAATTCAAATCTTGTATTAAGTTCCGTCGTTGGTGTTTCAGGATTACTCCC
AACAATTGAAGCATTAAAAGCGAAGAAAGATATTGCCATCGCTAATAAAGAAACGTTAGTTGCAGCTGGTCATATTGTAA
CTGAACTGGCCAAACAAAACGGATGTCGTTTAATTCCAGTCGATAGCGAACATTCAGCTATTTTCCAATGTTTAAACGGA
GAAAATAATAAAGAAATTGACAAATTAATCGTTACAGCTTCTGGCGGTGCATTCCGTGATAAAACACGTGAAGAAATGAA
AACTCTACAAGCAAAAGATGCTTTAAAGCACCCAAACTGGTTAATGGGGGCAAAACTAACGATTGATTCTGCCACGTTAA
TGAATAAAGGATTTGAAGTAATGGAAGCGAGATGGTTATTTGATATTCCTTATGAAAAAATTAATGTAATGATTCATAAA
GAAAGCATTATTCATTCTTTAGTAGAGTTTATCGATGGATCAGTTATAGCACAGCTCGGTGCTCCTGATATGAGGATGCC
GATTCAATATGCGTTTCACTACCCTACTCGGCTGCCTTCTTCCTATGAAAAATTAAATTTATTAGAAATCGGTAGTTTAC
ATTTTGAAAAACCAGATTTAGAGAAGTTTCCTTGTCTACAATACGCATATGAATGTGGCAAAATTGGTGGTACTACTCCT
GCTGTATTAAACGCAGCAAATGAAATTGCGAATGCACTATTCTTAAAAAATGAAATTGCCTTTTTCGATATTGAAAAAAC
AATTTACAAAACAGTTGAAGCCCATCATAACGTAAAAGATCCTTCACTAGATGCTATATTAGAAGCGGATCAATGGGCAC
GCCAATATGCAAATCAATTGTTAATAAAAAAGAGCTAA

Upstream 100 bases:

>100_bases
AACCCGAATTTTCTATTTTATTTAGCAGGAATTTCCACTTCAATTGTCTAATATTATATAGGTTTGCAGAAATACTCGAA
ACAACTTTGGAGGTTTTTTC

Downstream 100 bases:

>100_bases
AACAGATAATACTGTTTTAGCTCTTTTTCCTACGTATTCAACTTAACAAATCGATAACCGTGCGTAACTAACACTTTTAA
GATCGCATACCCTGGAATTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 1; 1-deoxyxylulose-5-phosphate reductoisomerase 1; 2-C-methyl-D-erythritol 4-phosphate synthase 1 [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGT
DGLITVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS

Sequences:

>Translated_385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGT
DGLITVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS
>Mature_385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATKELADTLRTRISTNTKITYGT
DGLITVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=39.1414141414141, Blast_Score=294, Evalue=8e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42576; Mature: 42576

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATK
CEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
ELADTLRTRISTNTKITYGTDGLITVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAI
HHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEE
ANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRD
CCCCCEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHH
KTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
HHHHHHHHHHHHHHHCCCCEEECCEEEECHHHHHHCCHHHHHEEEEEECCHHHEEEEEEH
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDL
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCC
EKFPCLQYAYECGKIGGTTPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKD
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
PSLDAILEADQWARQYANQLLIKKS
CCHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKTFQPRIVSVATK
CEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
ELADTLRTRISTNTKITYGTDGLITVATHPNSNLVLSSVVGVSGLLPTIEALKAKKDIAI
HHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEE
ANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRD
CCCCCEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHH
KTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
HHHHHHHHHHHHHHHCCCCEEECCEEEECHHHHHHCCHHHHHEEEEEECCHHHEEEEEEH
ESIIHSLVEFIDGSVIAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDL
HHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCC
EKFPCLQYAYECGKIGGTTPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKD
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
PSLDAILEADQWARQYANQLLIKKS
CCHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]