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The map label for this gene is ycgH [H]

Identifier: 218904243

GI number: 218904243

Start: 2960072

End: 2961415

Strand: Reverse

Name: ycgH [H]

Synonym: BCAH820_3127

Alternate gene names: 218904243

Gene position: 2961415-2960072 (Counterclockwise)

Preceding gene: 218904244

Following gene: 218904240

Centisome position: 55.85

GC content: 33.26

Gene sequence:

>1344_bases
ATGACCTGTCATGATGTTGAGAACGAAACGAAAGAAAAAAAAGATTTAAAATGGTGGCAACTCTCACTTATTGGGATTGG
CTGTACAATAGGGACCGGTTTCTTTTTAGGATCCAGTATAGGAATTAAAATAGGTGGTTCGTCAATTATTCTTATTCTTA
TTTTAACTGGATTTACTACTTATATTGTATTTGAAGCATTGGCAAAAATGGCTGTAGAAGATCCGCAAAAAGGATCTTTT
CGCATTTACTCAAAAAAAGCTTTTGGAAATTGGGCGGGTTTTAGTCATGGATGGACATACTGGTGTTCTGAACTGCTTAT
TATGGGCAGCCAGTTAGGTGCGTTAGGAATCTTTTCACGCTACTGGTTTCCTAAAATACCATTATGGATATTTGCTGCTA
TATACGGAGTAGCAGCTATATTAATTATTTTTATAGGGGTAAAGATATTTGAACGCCTAGAAAAATGGATGGCTATTATA
AAAATTGCGGCTATTATAGGATTCATCGTAATTGCTATTTTAGTTATTTTAGGATTTATAAAGGGTGGTTTATATAAAGC
ACAAATTCCGCGGGATTTTAAAGACTGGTTCCCAAATGGATTAAAAGGCACTTGGTCCTCTCTAATTTATGCATTTTATG
CATTTGGAGGAATCGAAATTATGGGGTTAATGACAATAAGACTGAAAGACCCTAAAGATGCACAAAAATCAGGAAGAGTA
ATGTTAATGATTTTAACGATTATTTACGTAGTTTCTTTAGGGTTGGCAATTATGATGGTTCCATTAAACCAGTTTAATAC
GAAAGAAAGCCCTTTTGTAATAGCATTACAAGACTATAATTTGCCGTATGTGCCATTTATTTTAAATGTAGTGTTAATTT
TAGCGGGTTTTTCAACATTAGTTGGTTCATTATTTGCAGTGACAAGTGTACTCATGAACTTAGCTGAAGAAGGTGATGCA
CCTGCAATGTTTGCTAAAAAAAACAAAAAAAACATCTCTTTTCCAGCTCTAATTCTTATTATAATTGGACTTGGTGCTTC
TATCCTTAGTGCTTTATTACTACCGAAAAATATATATGAATATGTAACAACTGCAGCTGGATTAATGTTGTTATATACAT
GGAGTCTCATTCTTCTTTCATTTTGGAGATTAATGAATCCAAAAGGTTGGATGCAGATAAAAAGCATTATTGGTCTTATA
ATGATTGCACTAGCTGTTAGTGGGACATTATTGCAAAAAACAACGCGTTTTGGTTTCCTAGTGAGCTTGTTGTTTTTAGG
AATAGTTATTATTGTTACTATAATTGTTCATTTTGTCTCAAAGAAAAGGAATACAGCTATATGA

Upstream 100 bases:

>100_bases
TAAAGGCTCATAATATCACTGATGTTATTGAAAAGCTTGCCGAGAAGTATTCAAGTGATCATGAGGGGCATTCTCAAAAT
GAATAAAGGAGAATAGTGAT

Downstream 100 bases:

>100_bases
AGAATCTATTTTTATACAATATGAGTAGTATGTAACAACTAAATAATAGAAGCTATTGAAAAATGATTTGGTAAGTTTGA
AAACCAAAATATAATCCATA

Product: amino acid permease family protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTCHDVENETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSF
RIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLGALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIIGFIVIAILVILGFIKGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSKKRNTAI

Sequences:

>Translated_447_residues
MTCHDVENETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSF
RIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLGALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIIGFIVIAILVILGFIKGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSKKRNTAI
>Mature_446_residues
TCHDVENETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSFR
IYSKKAFGNWAGFSHGWTYWCSELLIMGSQLGALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIK
IAAIIGFIVIAILVILGFIKGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRVM
LMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDAP
AMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIM
IALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSKKRNTAI

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=30.5010893246187, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786302, Length=386, Percent_Identity=28.2383419689119, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1790653, Length=394, Percent_Identity=28.4263959390863, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=26.7156862745098, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786789, Length=380, Percent_Identity=28.4210526315789, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=23.4782608695652, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789017, Length=376, Percent_Identity=27.1276595744681, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994972, Length=384, Percent_Identity=27.0833333333333, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788480, Length=398, Percent_Identity=27.1356783919598, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17532491, Length=397, Percent_Identity=22.4181360201511, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=418, Percent_Identity=26.555023923445, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320772, Length=402, Percent_Identity=25.8706467661692, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320251, Length=407, Percent_Identity=25.3071253071253, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=25.9445843828715, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324990, Length=401, Percent_Identity=25.9351620947631, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=25.0614250614251, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322892, Length=339, Percent_Identity=27.7286135693215, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321053, Length=414, Percent_Identity=24.6376811594203, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6321629, Length=397, Percent_Identity=23.4256926952141, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6319824, Length=400, Percent_Identity=25.25, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324924, Length=383, Percent_Identity=24.8041775456919, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=25.3807106598985, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322967, Length=343, Percent_Identity=25.3644314868805, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324059, Length=357, Percent_Identity=22.6890756302521, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319608, Length=349, Percent_Identity=22.9226361031519, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319543, Length=406, Percent_Identity=23.6453201970443, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324981, Length=354, Percent_Identity=24.0112994350282, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24667468, Length=420, Percent_Identity=22.8571428571429, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24668806, Length=414, Percent_Identity=21.9806763285024, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356285, Length=414, Percent_Identity=21.9806763285024, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24668802, Length=414, Percent_Identity=21.9806763285024, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49581; Mature: 49449

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCHDVENETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTT
CCCCCCCHHHHHHHCCHHHEEEEEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLGALGIFSR
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIIGFIVIAILVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSKKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TCHDVENETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTT
CCCCCCHHHHHHHCCHHHEEEEEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLGALGIFSR
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIIGFIVIAILVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRDFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSKKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]