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The map label for this gene is proC1 [H]

Identifier: 218904107

GI number: 218904107

Start: 2828050

End: 2828481

Strand: Direct

Name: proC1 [H]

Synonym: BCAH820_2991

Alternate gene names: 218904107

Gene position: 2828050-2828481 (Clockwise)

Preceding gene: 218904103

Following gene: 218904108

Centisome position: 53.33

GC content: 38.19

Gene sequence:

>432_bases
ATGTCTGCATTATGCCCGAATGAAATGGTGACAGAAAAAGATTTAGAAGATGTGCTAAACATTTTCAATAGCTTTGGTCA
ATCAGAGATTGTAAGTGAAAAATTAATGGACGTTGTAACATCTGTAAGTGGTTCTTCACCAGCATACGTATATATGATTA
TAGAAGCGATGGCAGATGCTGCTGTACTAGATGGTATGCCAAGAAATCAAGCATATAAATTCGCAGCTCAAGCTGTGTTA
GGCTCTGCAAAAATGGTACTAGAAACAGGAATACATCCTGGTGAATTAAAAGATATGGTTTGTTCTCCTGGCGGAACAAC
GATAGAAGCTGTAGCAACTTTAGAGGAAAAAGGCTTACGAACAGCCATCATTTCAGCTATGCAACGTTGTACACAAAAGT
CTGTCGAACTATCTGGTCAAACGAAAAAGTAA

Upstream 100 bases:

>100_bases
CGCTGCTGGAAAAAGTATCAAAAGTACAGAGGATTCTTTTGATACAAAATTAAAAGTTGTACGAGTAATGCCTAATACCC
CTGCCCTTGTTGGTGAAGGC

Downstream 100 bases:

>100_bases
AACTATAAAAGAGATCACGTTAGTTATGAATTTACATGCATTTAATTAATAAATAGTGGATTACATACTCTCCTGTTTTA
TCTTTTATTATATCGAAATA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MSALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVL
GSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLRTAIISAMQRCTQKSVELSGQTKK

Sequences:

>Translated_143_residues
MSALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVL
GSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLRTAIISAMQRCTQKSVELSGQTKK
>Mature_142_residues
SALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVYMIIEAMADAAVLDGMPRNQAYKFAAQAVLG
SAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLRTAIISAMQRCTQKSVELSGQTKK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=118, Percent_Identity=45.7627118644068, Blast_Score=109, Evalue=8e-25,
Organism=Homo sapiens, GI24797097, Length=118, Percent_Identity=44.9152542372881, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI24797095, Length=118, Percent_Identity=44.9152542372881, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI198041662, Length=119, Percent_Identity=44.5378151260504, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786585, Length=138, Percent_Identity=68.8405797101449, Blast_Score=201, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17540664, Length=148, Percent_Identity=40.5405405405405, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17569021, Length=133, Percent_Identity=41.3533834586466, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=132, Percent_Identity=34.0909090909091, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648116, Length=131, Percent_Identity=48.8549618320611, Blast_Score=132, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21358587, Length=132, Percent_Identity=46.969696969697, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647700, Length=132, Percent_Identity=46.969696969697, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 15267; Mature: 15136

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVYMIIEAMADA
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCHH
TAIISAMQRCTQKSVELSGQTKK
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SALCPNEMVTEKDLEDVLNIFNSFGQSEIVSEKLMDVVTSVSGSSPAYVYMIIEAMADA
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AVLDGMPRNQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCHH
TAIISAMQRCTQKSVELSGQTKK
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]